5 Matching Annotations
  1. Nov 2019
    1. 5.2 Metformin[edit] Reduced serum levels of vitamin B12 occur in up to 30% of people taking long-term anti-diabetic metformin.[71][72][73] Deficiency does not develop if dietary intake of vitamin B12 is adequate or prophylactic B12 supplementation is given. If the deficiency is detected, metformin can be continued while the deficiency is corrected with B12 supplements.[74]

      Fascinating overlap of two emergent life-extension-enhancement treatments.

  2. Nov 2017
  3. Jun 2017
    1. Just a few interconnected neurons (a microcircuit) can perform sophisticated tasks such as mediate reflexes, process sensory information, generate locomotion and mediate learning and memory.  More complex networks (macrocircuits) consist of multiple imbedded microcircuits.  Macrocircuits mediate higher brain functions such as object recognition and cognition.  So, multiple levels of networks are ubiquitous in the nervous system.  Networks are also prevalent within neurons.  These nanocircuits constitute the underlying biochemical machinery for mediating key neuronal properties such as learning and memory and the genesis of neuronal rhythmicity.

      So: Nanocurcuits inside neurons. A few Neurons form a Microcurcuit and already perform amazing basic bodily functions. Put a few Microcurcuits of Neurons together into Macrocurcuits though and you have Troll 2. (NaMiMa)

  4. Apr 2017
    1. fears have not diminished and may have prompted calls and means for voluntary euthanasia. This process appears to have occurred in parallel with what has been described as the ‘Alzheimerisation of ageing’. Reinforced by media reports of ‘institutional abuse’ in nursing homes, the intensified search for ‘a cure’, and the dire predictions of demographic apocalypse. The Alzheimerisation of ageing seems to contribute to the propagation of an associated and potentially negative ‘neuro-culture’ spread across the whole of society (Williams, Higgs & Katz, 2012).

      Dementia and old age as part of negative neuro-culture'