If the protein is subject to changes in temperature, pH, or exposure to chemicals, that change the nature of or interfere with the associations between functional groups, the protein's secondary, tertiary and/or quaternary structures may change, even though the primary structure remains the same. This process is known as denaturation
From previous knowledge, a cell,molecule, etc. usually denatures if the temperature is too high, chemical exposure and pH change. But can it also denature when the temperature drops down too low?