- Sep 2019
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www.scienceintheclassroom.org www.scienceintheclassroom.org
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intranasal administration
The process of inserting drug molecules through the nose.
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Brownian-like
Following a path similar to the Brownian motion of small particles in fluid, which is random movement due to continuous collisions with the surrounding molecules in the fluid.
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expectorated
Coughed out from the throat or lungs.
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encapsulation
Trapping something inside another object, or a capsule.
Here, encapsulation refers to trapping drug molecules inside the nanoparticle.
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complexation
The process of combining different atoms, ions, or molecules to form one large molecule or ion due to electrostatic and/or hydrophobic interactions.
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corticosteroids
Steroid hormones that are produced in the kidneys or synthetically in the laboratory and can be used to treat inflammations.
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colloidal stability
Refers to the particles' ability to stay dispersed in a fluid without separating from the solution (precipitation) or forming big clusters (aggregation) within a period of time.
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Hydrodynamic diameter
The diameter of a sphere that has the same hydrodynamic friction with that of the nanoparticle.
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noncovalent
A form of bonding that does not involve the bonding between pairs of atoms.
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hydrophobic
Repelled by water molecules.
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diblock copolymer
A polymer of two different polymer chains chemically bonded together in a specific order. For example, a linear diblock copolymer of the type A-B with 5 A monomers connected to 4 B monomers is a single chain A-A-A-A-A-B-B-B-B.
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triblock
A polymer of three different polymer chains, which are chemically bonded together in a specific order. For example, a linear triblock copolymer of the type A-B-C with 5 A monomers connected to 4 B monomers connected to 5 C monomers is a single chain A-A-A-A-A-B-B-B-B-C-C-C-C-C.
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well-PEGylated
Coated or surrounded in great extend by polymeric chains of poly(ethylene glycol).
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CF sputum
CF stands for cystic fibrosis, a disease in the lungs.
Sputum is a mixture of saliva and mucus that is produced because of a disease, such as cystic fibrosis, and comes out of the the human body through the passage formed from the mouth, nose, throat, and lungs.
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conjugating
The joining of two or more chemical compounds.
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in vitro
Experiments taking place in test tubes, culture dishes, or other controlled environments outside of living organisms.
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ex vivo
Experiments that take place in controlled external environments on tissues extracted from living organisms.
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in vivo
Experiments taking place inside living organisms.
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retention
To absorb and continue holding or keeping on a surface.
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Mucoadhesive
Have the ability to stick to mucus.
Mucus is a slimy substance that is produced in the human body (e.g. nose, throat, cervix) to protect and lubricate specific areas.
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pulmonary drug delivery
A pulmonary process is related to lung tissue.
Pulmonary drug delivery is the insertion of drug molecules to the human body through mouth to reach the lungs and treat lung-related diseases.
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