Clots also formed with the PPP with the addition of the spike protein, but not as disruptive as the COVID-19 PPP clots

Interestingly, these clots did not propagate much after the initial burst, indicating that most of the thrombin was consumed in a short period of time

reaction between thrombin and PPP occurred rapidly, resulting in large clots after approximately 90 s

disorderly clots that cover the bulk of the channel and often protruding into the center of the flow channel and disrupting flow

PPP with added spike protein showed a combination of a fibrous laminar clot and disorderly clotted mass

clot formation was also less frequent

clot had orderly layers that did not disrupt flow through the centre of the channel

Clots formed in healthy PPP were relatively small and were limited to the walls of the flow channel

In healthy plasma, clot formation was a relatively slow and gradual process, resulting in the formation of a modest clot

anomalous deposits that is amyloid in nature

spontaneously formed fibrin network

Whole blood sample of healthy volunteers, before and after exposure to spike protein

formation of spontaneous and anomalous fibrin(ogen) deposits with an amyloid nature, were prominent in all the samples incubated with spike protein, without the addition of thrombin

An increase in platelet hyperactivation, membrane spreading

WB incubated with spike protein showed erythrocyte agglutination, despite the very low concentration of the spike protein

targeting it directly, whether via vaccines or antibodies, is likely to be of therapeutic benefit.

conclude that the spike protein may have pathological effects directly, without being taken up by cells

comparing naïve healthy platelet-poor plasma (PPP) samples, with and without added spike protein

also determine if the spike protein may interfere with blood flow

directly interact with platelets and fibrin(ogen) to cause fibrin(ogen) protein changes and blood hypercoagulation

infected cells liberates free receptor binding domain-containing S1 particles

Free spike protein can potentially be released due to spontaneous ‘firing’ of the S protein trimers on the surface of virions

Free S1 particles may also play a role in the pathogenesis of the disease

S1 proteins can also cross the blood–brain barrier

Spike protein, can however be shed

spike proteins are the key factors for virus attachment

inflammatory biomarkers

platelets

numerous reports of damage to erythrocytes

Plasma of COVID-19 patients also carries a massive load of preformed amyloid clots

substantial deposition of microclots in the lungs

Endotheliopathies are therefore a key clinical feature of the condition

directly bind to endothelial receptors

dysregulated inflammatory coagulation biomarkers,

hypercoagulation and thrombosis

Phenotypic vascular characteristics are strongly associated with various coagulopathies

important clinical relevance in the treatment of hypercoagulability in COVID-19 patients.

lytic impairment may result in the persistent large microclots

cause substantial impairment of fibrinolysis

we suggest that, in part, the presence of spike protein in circulation may contribute to the hypercoagulation in COVID-19

roteins were substantially resistant to trypsinization, in the presence of spike protein S1

prothrombin

complement 3

β and γ fibrin(ogen)

Mass spectrometry also showed that when spike protein S1 is added to healthy PPP, it results in structural changes

we show that spike protein may interfere with blood flow

directly

cause blood hypercoagulation

investigate the potential of this inflammagen to interact with platelets and fibrin(ogen)

effect of isolated SARS-CoV-2 spike protein S1 subunit as potential inflammagen

One of the most important pathologies, is hypercoagulation and microclots

there is a significant difference in peptide structure before and after spike protein addition

less resistant to trypsinization

Is the Child’s Therapist Part of the Problem? What Judges, Attorneys, and Mental HealthProfessionals Need to Know About Court-related Treatment for ChildrenLYN R. GREENBERG, PH.D.*, JONATHAN W. GOULD,PH.D.**, DIANNA J. GOULD-SALTMAN, ESQ.***,PHILIP M. STAHL, PH.D.****I.

parents are provided legal representation to address a range of civil legal problems that could create family instability

There is an increased likelihood of psychotic symptoms with lifetime PTSD diagnoses

nTrauma exposure leads to various psychiatric disorders including depression, anxiety, bipolar disorders, personality disorders, psychotic disorders, and trauma related disorders, especially posttraumatic stress disorder (PTSD

person with delusional disorder may be high functioning in daily life

Apart from their delusion or delusions, people with delusional disorder may continue to socialize and function in a normal manner and their behavior does not necessarily generally seem odd.[

Delusional disorder, traditionally synonymous with paranoia, is a mental illness in which a person has delusions, but with no accompanying prominent hallucinations, thought disorder, mood disorder, or significant flattening of affect.[7][8] Delusions are a specific symptom of psychosis. Delusions can be bizarre or non-bizarre in content;[8] non-bizarre delusions are fixed false beliefs that involve situations that could occur in real life, such as being harmed

bullied?TRAUMA TRIggERS In cURREnT PlAcEMEnT

some children do not recover on their own.

Explain to the child that he or she is not responsible for what happened. Children often blame themselves for events

impact of child traumatic stress can last well beyond childhood.

self-harming behaviors

signs of traumatic stress are different in each child

important to learn how traumatic events affect children

reported experiencing multiple and repeated traumatic events

violent loss of a loved one

life-threatening illnes

events overwhelm a child’s or adolescent’s ability to cope

InvestigationReportDearMr.Furman:Asyouareaware,ourlawfirmservesasCountyAttorneyforWashingtonCounty,Colorado.Thisletterissenttoyouinyourcapacityas

Andrea Marsh

Alicia told me that the Bernhardts “can be victims, too.” Once the system “put this idea in their heads that adoption could be an achievable goal for them, it damaged our family, and my son, and the foster parents’ family.”

We didn’t do any of this for any reason other than to make sure that Carter has the best life,” J’Lyn told me later. “He deserves that.”

they’d paid around thirty-two thousand dollars to Eirich’s firm.

he is on target developmentally, and even “potentially gifted.” When I mentioned to Baird that there is little sign of the attachment trauma she predicted, she said this just demonstrates that Carter knows he has to “hero on.”

Can we tell Dad I slept so good?” he asked his mom with excitement one morning, and Alicia wondered if he knew or sensed that his sleep problems had been debated for years.

could do anything about it.

February, the judge asked for an explanation of what, exactly, was still unfit about Alicia and Fred as parents

Two days later, a letter from an attorney representing Washington County revealed that an internal investigation had found improprieties in the handling of Carter’s case. (The investigative report is under a gag order, and neither Smith nor the new director would elaborate on the resignation.) The trial was cancelled

director of the Department of Human Services, Grant Smith, resigned.

Washington County had spent more than three hundred and ten thousand dollars on Carter’s case: on his brain-mapping and medical exams, on the many expert evaluations, on Baird’s travel to and from Denver, on payments to the Bernhardts, and so on

They filed a Colorado Open Records Act request, and soon received dozens of invoices.

Last year, the Kempe Center’s director asked Baird in an e-mail to stop using the Kempe name to describe her protocol an

Baird has long called her technique for evaluating

had again brought in an expert—Diane Baird—to assess

the judge did little but say that he would await responses to a motion and schedule another hearing

judge, for his part, lamented all the medical tests. “We’re going to turn this kid into a lab rat,” he said

they couldn’t hear, let alone counter, much of what the county’s lawyer was saying about them

sitting cross-legged on their living-room floor,

Janina Fariñas, another clinical psychologist who evaluated him for the county, told me, “There was almost a need for Carter to not be O.K.”

therapist

A clinical psychologist found that he had normal social functioning for his age but that the fuzz-eating could be attributed to pica, a condition marked by eating non-food items, and that other signs of distress might be caused by “upbringing away from parents.”

experts

tests

Paul Spragg, a Colorado forensic psychologist

Foster Source

veteran nurse practitioner

What is the process at this point?” she wrote. “Will I hear from you or should I expect to hear from someone else? Is there anything else I can/should be doing to be prepared for baby and court? Should I plan a visit to Colorado to meet [the child] or to meet persons involved?”

She has significant experience,” the judge said,

only a preference under state laws. The judge rule

, as Eirich underlined to me, though parents have a constitutional right to their child until such right is terminated

but you’re also being blamed

in reality, children may be dysregulated for any number of reasons—perhaps they miss their parent, feel confused, or are simply behaving as toddlers do.” Green used to employ the dysregulation claim in her own cases, she said. She now regrets it.

Allison Green, the legal director of the National Association of Counsel for Children,

gave his foster parents more time to make their central argument

remained in foster care, with no transition home planned.

social worker had explained that Eirich and Baird “went around the state together,” arguing for the termination of birth-parents’ rights

Another judge, recognizing Fred’s transformation, had recently granted him full custody of his other son, Robert, who was twelve years old.

The problem was that Alicia and Fred would not give up.

A healthy attachment trumps biology in the first three years of life, period,”

an attachment expert whom she has trained.

intervenor-training sessions for judges and foster parents

When the American Academy of Pediatrics reviewed

foster children were becoming a “hot commodity,” he said

prominent local ranching family

expert

saying that their visits with him were threatening his primary attachment and causing “a biologic hyperarousal that not only burns calories but self-perpetuates”—a state that becomes worrisome when a child spends “twenty-five to fifty-seven per cent of their time, or whatever,” in it. Rupturing a primary attachment could ultimately cause “sociopathy” in a child, she said.

judge

without having met them.

hundreds

as an expert

Although hired as a consultant by Washington County in this case, Baird had a long-standing independent agenda: helping foster parents across Colorado succeed in intervening and permanently claiming the children they care for. Often working hand in hand with Tim Eirich

Did Baird not understand how hard it is to bond with a baby you’ve been allowed to see for only a few hours a week, while masked, or in fifteen-minute stints on Zoom

social worker named Diane Baird

the sentence under this section for such offense shall include imprisonment for not less than 20 years

Special Rule for Certain Offenses Involving Children

c) If two or more persons conspire to violate this section and one or more of such persons do any overt act to effect the object of the conspiracy, each shall be punished by imprisonment for any term of years or for life.

shall be punished by imprisonment for any term of years or for life

any person

kidnaps

) Whoever unlawfully

Kidnapping

Kidnapping -- 18 U.S.C. § 1201

Section 1201(d) prohibits attempts to kidnap

Section 1201(c) prohibits conspiracy to kidnap and authorizes "imprisonment for any term of years or for life."

no proof of harm to the victim is required to support any such sentence

The maximum permissible punishment is imprisonment for any term of years or for life

Section 241 makes it unlawful for two or more persons to agree to injure, threaten, or intimidate a person in the United States in the free exercise or enjoyment of any right or privilege secured by the Constitution or laws of the United States

penalties up to and including life in prison or death

kidnapping

A violation of the statute is a misdemeanor, unless prosecutors prove one of the statutory aggravating factors such as

failing to protect someone in custody from constitutional violations committed by others

The Department has also prosecuted public officials for

Section 242 does not criminalize any particular type of abusive conduct.  Instead, it incorporates by reference rights defined by the Constitution, federal statutes, and interpretive case law.

Those prosecuted under the statute typically include police officers, sheriff’s deputies, and prison guards.  However other government actors, such as judges, district attorneys, other public officials, and public school employees can also act under color of law and can be prosecuted under this statute.

Section 241 is used in Law Enforcement Misconduct

used

in Human Trafficking prosecutions

MISCONDUCT

OTHER GOVERNMENT ACTORS

This provision makes it a crime for someone acting under color of law to willfully deprive a person of a right or privilege protected by the Constitution or laws of the United States

Defendants act under color of law when they wield power vested by a government entity

It is punishable by up to ten years imprisonment unless the government proves an aggravating factor (such as that the offense involved kidnapping

The offense is always a felony, even if the underlying conduct would not, on its own, establish a felony violation

Unlike most conspiracy statutes, §241 does not require, as an element, the commission of an overt act

The offense is punishable by a range of imprisonment up to a life term, or the death penalty, depending upon the circumstances of the crime, and the resulting injury

not necessary that the crime be motivated by animus toward the race, color, religion, sex, handicap, familial status

others who are acting as public officials

care providers

judges

include

makes it a crime for a person acting under color of any law to willfully deprive a person of a right or privilege protected by the Constitution or laws of the United States.

Deprivation Of Rights Under Color Of Law

TRAUMA: What Child Welfare Attorneys Should KnowTABLE

If the child is removed, request a copy of the family’s prevention plan to review what the agency offered and whether reasonable efforts have been made to prevent removal (if necessary, request through the discovery process). If reasonable efforts were not made, request a “no reasonable efforts” finding at the first hearing, and an order returning the child to the family with appro-priate services

Using the Family First Prevention Services Act to Strengthen Reasonable Efforts Determinations

discuss their roles in cancers, neurodegeneration, autoimmune, inflammation, infection and cardiovascular diseases (CVDs),

ncreases in rMSSD and HF over time were associated with a significant increase in survival

The specific link between the autonomic ner-vous system and the immune system is through an anti-inflammatory circuit, the inflammatory reflex, surrounding the vagus nerve, which is an important component of the parasympathetic nervous system (Rosas-Ballina et al., 2011; Rosas-Ballina & Tracey, 2009; Tracey, 2002). The inflammatory reflex works by sensing the activity of proinflammatory cytokines through an afferent pathway (Olofsson, Rosas-Ballina, Levine, & Tracey, 2012) and informs the brain of malignancies. An efferent response is then elicited, in which signals from the brain, via the vagus nerve, stimulate acetylcholine-producing T cells. In turn, the T cells activate anti-inflammation processes by inhibiting proinflammatory cytokine production (Olofsson et al., 2012; Rosas-Ballina et al., 2011). The vagus nerve affects the maturation and reduction of cancerous tumor cells because of its role in immune system signaling and regulating (De Couck et al., 2013; De Couck, Mravec, & Gidron, 2012; Levy, Herberman, Lippman, D’Angelo, & Lee, 1991; Mravec, Gidron, & Hulin, 2008; Rosas-Ballina & Tracey, 2009)

I will never forget Anna nor the lessons her courage andspirit have taught me about life and living.

the avoidance behaviorsare ultimately what will cause fear

What I have learned is that even though most of us mighttry to avoid thinking

if we allow ourselves tomeet those around us as our equals, a natural sense of em-pathy, kindness, and connectedness starts to emerge

felt a sincere sense of serenity as a resultof the relatedness I felt with the patients and mankind ingeneral

I found myself faced with the poignantdefenselessness of these patients, and then I too was forced totake my fences down. And for me, when those boundaries felland I was confronted with life’s realities of suffering andmortality,

this nat-ural tendency to shield ourselves from seemingly unbearablefeelings also prevents us from opening our hearts and genu-inely connecting with others

sorrow and grief, thatwe, perhaps too often, try to avoid in our daily lives, as weassociate these feelings with discomfor

they help us toavoid painful feelings, but thereby also deny us access toourselves and others

Defensescan disconnect us from the rest of humanity

ollowed were years of struggle thatfluctuated between living on the streets and living in home-less shelters.all with her five children. Then, as if lifewould never plan on giving this brave woman a break, shemost recently was diagnosed with desmoplastic small roundcell tumor, a rare form of incurable cancer

inally broke free from her abusive homeat the age of 18

lived with her grandpar-ents, who made her feel responsible for her godfather’s re-lentless abuse.

suffered horrendousabuse by her godfather throughout the better part of herchildhood and adolescence. Neglected and abandoned by hersubstance-dependent mother

he Gift of Connection:A Personal Reflection on My Work with Cancer PatientsCaroline Scheiber, MA

In brotherly love there is the experience of union with all men

The Teenage Brain - Webinar April 27, 2020. Speakers: Caroline Scheiber, PhD and Leah Kaplan, LPC

impaired cognitive functioning following cancer diagnosis and treatment may be the result of a preexisting vulnerability due to exposure to childhood trauma (Lupien et al., 2009; Miller, Chen, & Zhou, 2007). In that regard, trauma should be considered, among other factors, in treatments aiming to address difficulties with cognitive functioning

Conceivably, cognitive functioning difficulties may not be attributable directly to the steepness or flatness of the cortisol slope, but instead to how the overall system responds to a particular endogenous or exogenous challenge

The relationship between childhood trauma and cognitive functioning remained significant even after controlling for age, education, time since chemotherapy treatment, insomnia, anxiety, and depression.

Multiple studies have shown that memory and learning are impaired

restrict capacity for learning and memory formation

hippocampus is particularly vulnerable

exposure to childhood trauma may also put women at risk of cognitive functioning difficulties after breast cancer diagnosis and treatment.

in the specific context of cancer

overproduction of glucocorticoids, including cortisol, has a direct impact on cognitive functioning among people in general

person’s age when exposed to trauma, he or she may develop long-term HPA suppression or hyperactivity, causing the HPA axis to be easily activated by stress and to continue to produce glucocorticoids even after a threat has passed

result in persistent alteration of hypothalamic-pituitary-adrenal (HPA) activity

implement early interventions to improve long-term cognitive outcome