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   Endo-lysosomal sorting and degradation of Tau mediates glucocorticoid-driven hippocampalmalfunction

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   Actin filaments regulate microtubule growth at the centrosome.

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   Sphingolipid metabolic flow controls phosphoinositide turnover at thetrans Golgi network

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   The β3-integrin endothelial adhesome regulates microtubule dependent cell migration

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   Mapping In Vivo O-Glycoproteome Using Site-specific Extraction of O-linked glycopeptides (EXoO)

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   Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing

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   F-actin patches associated with glutamatergic synapses control positioning of dendritic lysosomes

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   A genetic system for generating single-sex progeny in mice

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    Multiple C2 domains and Transmembrane region Proteins (MCTPs) tether membranes at plasmodesmata

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    Functional systemic CD4 immunity is a differential factor for clinical responses to PD-L1/PD-1 blockade therapy in lung cancer

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    Disentangling bacterial invasiveness from lethality in an experimental host-pathogen system

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    RASSF1A Is Required For The Maintenance Of Nuclear Actin Levels

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    Stalk-mediated communication in the dynein motor domain

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    Euchromatic histone methyltransferases regulate peripheral heterochromatin tethering via histone and non-histone protein methylations

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    Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice

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    PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure

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    LRX- and FER-dependent extracellular sensing coordinates vacuolar size for cytosol homeostasis

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    The nucleoporin ELYS regulates nuclear size by controlling NPC number and nuclear import capacity

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    Absolute quantification of translational regulation and burden using combined sequencing approaches

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    Triggering MSR1 promotes JNK-mediated inflammation in IL-4 activated macrophages

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    Mechanistic causes of constrained phenotypic variation revealed by synthetic gene regulatory networks

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    The fitness cost and benefit of phase separated protein deposits

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    Defining the RNA Interactome by Total RNA-Associated Protein Purification

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    SWI/SNF chromatin remodeling controls Notch-responsive enhancer accessibility

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    Asymmetric Distribution of Glucose Transporter mRNA Provides Growth Advantage

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    In situ and high-resolution Cryo-EM structure of the Type VI secretion membrane complex

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    Structural basis of HEAT-kleisin interactions in the human condensin I subcomplex

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    Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy

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    Evidence that the cell cycle is a series of uncoupled, memoryless phases

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    The fungal root endophyte Serendipita indica modifies extracellular nucleotides to subvert plant immunity

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    netDx: Patient classification using integrated patient similarity networks

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    SSU72 phosphatase is a telomere replication terminator

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    De novo Gene Signature Identification from Single-Cell RNA-Seq with Hierarchical Poisson Factorization

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    Quantification and discovery of sequence determinants of protein per mRNA amount in 29 human tissues

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    A deep proteome and transcriptome abundance atlas of 29 healthy human tissues

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    Structures of the heart specific SERCA2a Ca2+-ATPase

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    Choreography of budding yeast chromosomes during the cell cycle

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    Length-independent telomere damage drives cardiomyocyte senescence

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    Widespread inter-individual gene expression variability in Arabidopsis thaliana

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    CRISPR Cas9 searches for a protospacer adjacent motif by one-dimensional diffusion

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    High-resolution mapping of cancer cell networks using co-functional interactions

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    CDK phosphorylation of Xenopus laevis M18BP1 promotes its metaphase centromere localization

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    Activated BAX/BAK enable mitochondrial inner membrane permeabilisation and mtDNA release during cell death

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    Bimodal Spindle Orientation Drives Tissue Regularity in a Proliferating Epithelium

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    The key protein of endosomal mRNP transport binds translational landmark sites of cargo mRNAs

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    Murine MPDZ-Linked Hydrocephalus is Caused by Hyperpermeability of the Choroid Plexus

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    S phase R-loop formation is restricted by PrimPol-mediated repriming

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    A common molecular logic determines embryonic stem cell self-renewal and reprogramming

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    Functional Compensation Between Hematopoietic Stem Cells In Vivo

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    Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability

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    Synergistic Recruitment of UbcH7~Ub and Phosphorylated Ubl Domain Triggers Parkin Activation

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    Synthesis and degradation of FtsZ determines the first cell division in starved bacteria

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    Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth

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    ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival

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    Transcriptional control and exploitation of an immune-responsive family of retrotransposons in Arabidopsis

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    Fibroblasts from metastatic sites induce broad-spectrum drug desensitization via modulation of mitochondrial priming

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    Paupar LncRNA Promotes KAP1 Dependent Chromatin Changes And Regulates Subventricular Zone Neurogenesis

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    TRIP6 inhibits the Hippo signaling pathway in response to tension at adherens junctions

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    CTCF, WAPL and PDS5 proteins control the formation of TADs and loops by cohesin

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    Whole chromosome loss in tetraploid cells confers tumorigenic potential in a mouse allograft model

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    Non-canonical circadian oscillations in Drosophila S2 cells drive gene-expression cycles coupled to metabolic oscillations

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    Bicoid gradient formation mechanism and dynamics revealed by protein lifetime analysis

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    Ratiometric Distribution Of OCT4 During Stem Cell Division Controls The Balance Between Self-Renewal And Differentiation

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    Multi-Omics factor analysis disentangles heterogeneity in blood cancer

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    FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.

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    Fibroblast state switching orchestrates dermal maturation and wound healing

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    Household triclosan and triclocarban exposure impacts the adult intestinal microbiome but not the infant intestinal microbiome

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    MODELING SIGNALING-DEPENDENT PLURIPOTENT CELL STATES WITH BOOLEAN LOGIC CAN PREDICT CELL FATE TRANSITIONS

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    Genome-wide phenotypic analysis of growth, cell morphogenesis and cellcycle events in Escherichia coli.

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    Structure of the archaellar motor and associated cytoplasmic cone in Thermococcus kodakaraensis

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    A synthesis of over 9,000 mass spectrometry experiments reveals the core set of human protein complexes

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    A two-state photoconversion model predicts the spectral response dynamics of optogenetic systems

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    Unraveling mitotic protein networks by 3D multiplexed epitope drug screening

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    Mapping DNA damage-dependent genetic interactions in yeast via orgy mating and barcode fusion genetics

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    LINE-1 repression attenuates degeneration in adult dopaminergic neurons

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    The Trithorax group protein dMLL3/4 instructs the assembly of the zygotic genome at fertilization

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    GTSF-1 is required for the formation of a functional RNA-dependent RNA Polymerase complex in C. elegans

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    A temporally dynamic Foxp3 autoregulatory transcriptional circuit controls the effector Treg programme

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    X10 Expansion Microscopy Enables 25 nm Resolution on Conventional Microscopes

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    Lateral plasma membrane compartmentalization links protein function and turnover

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    FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells

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    Expression variation and covariation impair analog and enable binary signaling control

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    Strong homeostatic TCR signals induce formation of self-tolerant virtual memory CD8 T cells

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    Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib

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    Real-time observation of flexible domain movements in Cas9

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    Structure of the human pro-myostatin precursor and determinants of growth factor latency

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    Photoperiodic control of the Arabidopsis proteome reveals a translational coincidence mechanism

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    A Map Of Genetic Interactions In Cancer Cells

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    Structure of the eukaryotic cytoplasmic pre-40S ribosomal subunit

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    Antisense transcription-dependent chromatin signature modulates sense transcription and transcript dynamics

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    Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells

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     High-throughput identification of RNA nuclear enrichment sequences

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     Tolloid cleavage activates latent GDF8 by priming the pro-complex for dissociation

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     Assigning Function To Natural Allelic Variation Via Dynamic Modeling Of Gene Network Induction

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     Mapping protein interactions of sodium channel NaV1.7 using epitope-tagged gene targeted mice

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     Expanding the Atlas of Functional Missense Variation for Human Genes

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     WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome

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     Resolving Drug Effects In Patient-Derived Cancer Cells Links Organoid Responses To Genome Alterations

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     A Mechanism of Cohesin-Dependent Loop Extrusion Organizes Zygotic Genome Architecture

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     The Landscape Of Human Mutually Exclusive Splicing

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     From word models to executable models of signaling networks using automated assembly

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     Aubergine And piRNAs Repress The Proto-Oncogene Cbl For Germline Stem Cell Self-Renewal

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     An "invisible" ubiquitin conformation is required for efficient phosphorylation by PINK1

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     Real-time detection of condensin-driven DNA compaction reveals a multistep binding mechanism

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     Initiation of DNA replication requires actin dynamics and formin activity

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     Combinatorial Regulation Of The Balance Between Dynein Microtubule End Accumulation And Initiation Of Directed Motility

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     CRISPR/Cas9 screening using unique molecular identifiers

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     In Situ Genotyping Of A Pooled Strain Library After Characterizing Complex Phenotypes

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     A Theory That Predicts Behaviors Of Disordered Cytoskeletal Networks

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     Cytosolic ribosomes on the surface of mitochondria

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     Remodeling of ER-exit sites initiates a membrane supply pathway forautophagosome biogenesis

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     Structural and Functional analysis of the GABARAP Interaction Motif (GIM).

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     Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands

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     High-throughput CRISPRi phenotyping in Streptococcus pneumoniae identifies new essential genes involved in cell wall synthesis and competence development

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     In vivo structures of an intact type VI secretion system revealed by electron cryotomography

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     Structure of the Legionella Dot/Icm type IV secretion system in situ by electron cryotomography

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     DNA sequence properties that predict susceptibility to epiallelic switching

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     A living vector field reveals constraints on galactose network induction in yeast

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     An RNA-binding tropomyosin recruits kinesin-1 dynamically to oskar mRNPs

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     Distinct Cellular States Determine Calcium Signaling Response

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     Polarized Cortical Tension drives Zebrafish Epiboly Movements

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     An Atlas of Human Kinase Regulation

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     A population-based temporal logic gate for timing and recording chemical events

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     Tyrosination of α-Tubulin Controls The Initiation of Processive Dynein-Dynactin Motility

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     Determinants of RNA metabolism in the Schizosaccharomyces pombe genome

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     Differential dynamics of the mammalian mRNA and protein expression response to misfolding stress

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     Efficient Search, Mapping, and Optimization of Multi-protein Genetic Systems in Diverse Bacteria

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     Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

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