QUESTION: Because this article talks about derivatives of an antibiotic that makes it harder for bacteria to resist, I would want to know how does the decay rate of this new derivative, more specifically 6j, compare to the decay rate of the original antibiotic. Therefore, would the drug have to be taken more or less frequently for optimum use. Also, if the 6j derivative stays in the blood stream, does the environment the bacteria could potentially create cause reversification back into the original form of the drug or into an ineffective form of the drug?

CONNECT: parent ring modification of pleuromutilin relates to the synthesis of thyroid hormone (T3 and T4) through parent ring modification. The parent ring undergoes ionization which adds either three or four iodines onto the benzene ring.

FACT: tosylation occurs with the use of TsCl which then adds a Ts onto O. Therefore, the O becomes a better leaving group which then allows for a better nucleophilic substitution to obtain the intermediate.

i love being able to see all that i write about