Genetic studies have also suggested that Sox10and Ednrb do not interact during murine melanocyte development (Hakami et al., 2006).
Sox10 is expressed in melanoblasts, which are the precursors of melanocytes, that do not contain Ednrb. Ednrb is expressed in embryos that do not contain Sox10. Therefore, Sox10 expression does not depend on the expression of Ednrb. (DB)