TLRs CLRs RLRs NLRs

-------Understand these, well.

Presume phagosomes are in-cell organelles. Wikipedia will answer this and more...

Do my best to understand in a general way some of the chemical bases for these pathways. Dr. Samuels possibly. Might get somewhere by looking up a few of the terms.

Wikipedia trail on opsonin.

Need a clear definition of "microbe." Presume indirect recognition of PAMPS is via the antibody/antigen mechanism described earlier. Worth asking.

Wonder if this is true in marine mammals, fish, worms that live in various environments. Am thinking with an evolutionary and developmental hat on. Just idle musing, wonder from a developmental perspective why acid and not alkaline (I think most soaps are alkaline) - mechanisms that differentiate breakoff points in the tree of life might be fun to learn about - to look smart.

Good beginning, lots of text that I can quickly annotate - appears to be a review article from 2009: Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

Do Wikipedia trails on all of the proteins and peptides in this list:

Lysozyme Lactoferrin Secretory leukocyte protease inhibitor S100 proteints, e.g.: psoriasin, calprotectin Defensins (alpha and beta) Cathelicidin Surfactant proteins SP-A, SP-D

Again, in the past I thought that these terms were describing molecular engines that were quite specific to particular antibody/antigen interactions. Guess not.

Lookup earlier uses of PAMP. Microbe is quite general, might be worth knowing what types of microbes.

Will check status.

Class was broken into ~6 groups. Each group presented assigned topics.

This assignment part of a summer course that met 4 mornings/wk for ~6 weeks with two afternoon labs/wk.

Textbook is Watson's Molecular Biology of The Gene, 7th Edition.