Referring to a targeted space over a period of time. In the context of the study, it emphasizes the importance of both the timing and location of nerve cooling for managing neuropathic pain.

Spared nerve injury is a type of nerve injury model used in research to simulate neuropathic pain conditions. Two of the three sciatic nerves are specifically targeted and injured (peroneal and tibial nerves), while the third nerve, the sural nerve, remains intact. This allows researchers to study neuropathic pain mechanisms and test potential treatments in animals.

Combined electrical activity generated by a group of nerve fibers when they are stimulated together.

Describes the sharp temperature contrast between the actively cooled regions of the cuff, which directly contact the nerve tissue, and the passive regions that do not. This indicates effective localized cooling, with the actively cooled areas being significantly cooler than the passive ones.

Other or opposite side of the body.

Tests simulated to study the animal's mechanical responses of the nervous system from painful stimuli.

It refers to the uniform formation of vapor bubbles within the liquid form of PFP, leading to the phase transition from liquid to vapor.

PFP is used as the gas phase that helps to spray the medication out of the inhaler when it is pressed.

Medical treatment that cools the body temperature of a patient for a specific period of time. It is used in certain types of brain injury to help reduce the risk of brain damage.

A sensor for measuring temperature.

Surgical stitches that close and hold a wound together while it heals

Characteristic of a material that has elastic properties and can reform original shape after removing applied forces.

Transplant of nerve tissue to help repair damaged nerves.

The researchers conducted an experiment using three rats where they studied the impact of the cooling cuff on the pain associated with the spared nerve injury (SNI). They observed that the threshold at which the animal feels pain in response to a mechanical force increased as the temperature of the SNI-treated nerve decreased. This increase indicates a notable reduction in pain sensation due to cooling, suggesting that cooling has a significant analgesic (pain-relieving) effect.

Referring to time or timing of events.

Surgery that is performed on the spine to relieve compressed nerves and reduce pressure on the spine and nerves. More space is created through this surgery to allow better movement of the nerves and help relieve pain.

Pain that is experienced immediately after surgery and can last up to a week.

Loss of sensitivity to pain in a specified area.

This refers to any nerve in the peripheral nervous system, which is comprised of the nerves in the body that branch out from the brain and spinal cord.

Meaning the drug or substance is not an opioid and contains no opioids.

Type of opioid that contains natural substances extracted from poppy plants. They are referred to as the natural opioids.

These are a class of drugs prescribed to treat severe pain.

Relating to medical procedures that involve cutting into the body and doing procedures typically deeper than surface level.

The capability of being absorbed or degraded into the body over time after it has been implanted.

Referring to an item that can be surgically put into and function within the body.

A term referring to drugs that are used to relieve pain.