Aortic dissection typically presents acutely with sudden, severe tearing chest or back pain, often described as lancinating in quality. [5-6] Approximately 50% of patients with thoracic aortic aneurysm may progress to dissection without timely intervention. [5] In contrast, thoracic aortic aneurysm is usually asymptomatic and discovered incidentally during physical examination or imaging for other indications. [5]
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- Mar 2026
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accessmedicine.mhmedical.com accessmedicine.mhmedical.com
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- CT angiography is the imaging modality of choice for differentiating these conditions in the emergency setting, with very high sensitivity and specificity for acute aortic syndromes
- Recent evidence suggests that inflammatory biomarkers may aid differentiation. The neutrophil-to-lymphocyte ratio (NLR) shows high diagnostic accuracy for distinguishing dissection from controls (AUC 0.933), while the fibrinogen-to-d-dimer ratio best differentiates dissection from aneurysm (AUC 0.898, sensitivity 77%, specificity 84%). [10] D-dimer levels below 500 ng/mL make acute aortic syndrome unlikely in low-risk patients
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- Mar 2025
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usrussiarelations.org usrussiarelations.org
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Mayakovsky assailed America for its lack of artistic appreciation and obsession with materialism. He chronicled his travels in his book, My Discovery of America.
Tell us more! What specifically did Mayakovsky dislike about America and Americans?
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- Mar 2021
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Results for individual PALB2 variants were normalized relative to WT-PALB2 and the p.Tyr551ter (p.Y551X) truncating variant on a 1:5 scale with the fold change in GFP-positive cells for WT set at 5.0 and fold change GFP-positive cells for p.Y551X set at 1.0. The p.L24S (c.71T>C), p.L35P (c.104T>C), p.I944N (c.2831T>A), and p.L1070P (c.3209T>C) variants and all protein-truncating frame-shift and deletion variants tested were deficient in HDR activity, with normalized fold change <2.0 (approximately 40% activity) (Fig. 1a).
AssayResult: 6.5
AssayResultAssertion: Normal
StandardErrorMean: 1.55
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A total of 84 PALB2 patient-derived missense variants reported in ClinVar, COSMIC, and the PALB2 LOVD database were selected
HGVS: NM_024675.3:c.629C>T p.(Pro210Leu)
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