Among these are the 25-nucleotide deletions in MYBPC3, p.R453C and p.G716R in MYH7, and p.R92W inTNNT2, all of which are clearly pathogenic and associated with a poor prognosis.
Variant(1) NM_000257.4:c.1357C>T
ClinVar: 14089
CAID: CA010630
Variant(2) NM_000257.4:c.2146G>A
ClinVar: 14105
CAID: CA011770