Uncovering secrets of the proteome: Alternate RNA decoding & Protein asymmetry shaping cell fate

This presentation "Uncovering the secrets of the human proteome" was given in May 2024 at the 50th anniversary celebration of the Barnett Institute. It focused on progress in proteomics and two new discoveries: 1. Alternate RNA decoding results in stable and abundant proteins in mammals 2. Proteome asymmetry in mouse and human embryos before fate specification

The vastness and complexity of the human proteome have hampered its exploration. New mass spectrometry technologies are transcending those limitations and allowing for large gains in sensitivity, sequence coverage, spatial and temporal resolution. I will discuss the conceptual drivers of this progress and provide examples of how it will advance our understanding of the human proteome and enable better therapeutics.

https://youtu.be/F4-PUuz5kcQ?si=5iHIshGprYutcRih