This study focuses on higher education instructors in the Global South, concentrating on those located in South America, Sub-Saharan Africa, and South and Southeast Asia. Based on a survey of 295 instructors at 28 higher education institutions (HEIs) in nine countries (Brazil, Chile, Colombia; Ghana, Kenya, South Africa; India, Indonesia, Malaysia), this research seeks to establish a baseline set of data for assessing OER use in these regions while attending to how such activity is differentiated across continental areas and associated countries. This is done by examining which variables – such as gender, age, technological access, digital literacy, etc. – seem to influence OER use rates, thereby allowing us to gauge which are the most important for instructors in their respective contexts.The two research questions that drive this study are:1. What proportion of instructors in the Global South have ever used OER?2. Which variables may account for different OER usage rates between respondents in the Global South?