Granted, how a natural entity can have interiority, i.e., subjectivity, is a hard problem, but if the question of integration and unification is not identical to the “Hard Problem of Consciousness” (Chalmers 1995) it is also inseparable from it and surely a presupposition of the very possibility of interiority. Nor would even an understanding of how subjectivity could be resident to a single cell tell us how consciousness could become an integrated unity across many cells. If we assume consciousness is a physically based phenomenon, and that it draws upon the activity of various parts of the brain, let alone constituent cells, then we must face our deficits in understanding how the experience of a unified consciousness is realized at the level of an integration of some cells but not others albeit in the absence of evident, non-arbitrary, physical boundaries.