3 Matching Annotations
  1. Jul 2021
    1. Keerthivasan, S., Şenbabaoğlu, Y., Martinez-Martin, N., Husain, B., Verschueren, E., Wong, A., Yang, Y. A., Sun, Y., Pham, V., Hinkle, T., Oei, Y., Madireddi, S., Corpuz, R., Tam, L., Carlisle, S., Roose-Girma, M., Modrusan, Z., Ye, Z., Koerber, J. T., & Turley, S. J. (2021). Homeostatic functions of monocytes and interstitial lung macrophages are regulated via collagen domain-binding receptor LAIR1. Immunity, 54(7), 1511-1526.e8. https://doi.org/10.1016/j.immuni.2021.06.012

  2. Jun 2021
    1. SARS-CoV-2 spike protein can induce IL-8, IL-6 and TNF-α secretion in monocyte-derived macrophages (MDMs)

      Suggested mechanism for this is via Spike protein binding TLR4, this can be blocked with NFkB and TLR4 inhibitors potentially offering a therapeutic strategy https://doi.org/10.1101/2020.12.18.423427

      Additionally SARS-CoV-2 nucleocaspid can drive IL-6 in macrophages https://doi.org/10.3390/vaccines9010054

      SLAMF7 'super activation' has been detected in lung infiltrating and monocyte derived macrophages of COVID19 patients resulting in significant upregulation of proinflammatory cytokines https://doi.org/10.1101/2020.11.05.368647 (preprint)

  3. Mar 2021
    1. As macrophages express ACE-2, direct infection with SARS-CoV-2 could prevent IFN I production (a viral evasion mechanism discussed in Part 1 of this review) impairing viral control and causing hyperinflammation [67].

      It is not thought that circulating immune cells (i.e. monocytes) become infected with SARS-CoV-2 to a large extent https://doi.org/10.1101/2021.01.19.427282

      Additionally, a study showed that SARS-CoV-2 does not readily infect human monocyte derived macrophages nor drive significant cytokine production https://doi.org/10.1101/2020.12.22.423940

      However, this is not seen in other studies and the cells primarily thought to be infected would rather be lung alveolar macrophages. These have different receptors, origins (i.e. embryonic vs monocyte perhaps), and are in an in situ setting unlike studies with in vitro-derived monocytic macrophages (6-day culture with only one growth factor). Therefore, this is still unclear.