- Jul 2020
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pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
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voxel-based morphometry
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depressive patients without anxiety disorder (DP group, n = 18)
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The DP group showed decreased GMV in the left insula (INS) and left triangular part of the inferior frontal gyrus when compared to the NC group.
Observation: Decreased Volume AnalysisMethod: volume Location: Left Insula SubjectGroups: DP compared to NC
Observation: Decreased Volume AnalysisMethod: volume Location: left triangular part of the inferior frontal gyrus (pars triangularis) SubjectGroups: DP compared to NC
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The DPA group showed greater GMV in the midbrain, medial prefrontal cortex, and primary motor/somatosensory cortex when compared to the NC group
Observation: Increased Volume AnalysisMethod: volume Location: midbrain SubjectGroups: DPA compared to NC
Observation: Increased Volume AnalysisMethod: volume Location: medial prefrontal cortex SubjectGroups: DPA compared to NC
Observation: Increased Volume AnalysisMethod: volume Location: primary motor/somatosensory cortex SubjectGroups: DPA compared to NC
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the DPA group showed greater GMV than the DP group in the frontal, INS, and temporal lobes
Observation: Increased Volume AnalysisMethod: volume Location: frontal lobe SubjectGroups: DPA compared to DP
Observation: Increased Volume AnalysisMethod: volume Location: Insula SubjectGroups: DPA compared to DP
Observation: Increased Volume AnalysisMethod: volume Location: temporal lobe SubjectGroups: DPA compared to DP
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Most gray matter anomalies were significantly correlated with depression severity or anxiety symptoms.
Observation: significant AnalysisMethod: correlation Location: Volume:most gray matter anomalies, Clinical: depression severity or anxiety symptoms SubjectGroups: DPA and DP
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region-of-interest analyses of gray matter volume (GMV)
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normal controls (NC group, n = 28)
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depressive patients with anxiety disorder (DPA group, n = 20)
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pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
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clinical high risk (CHR) for psychosis
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self-reported and interviewer-rated measures of social functioning
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voxel based morphometry (VBM)
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the CHR group had less GMV in the left postcentral gyrus, bilateral parahippocampual gyri, and left anterior cingulate cortex
Observation: reduced volume AnalysisMethod: vbm Location: left postcentral gyrus SubjectGroups: CHR compared to HC
Observation: reduced volume AnalysisMethod: vbm Location: bilateral parahippocampual gyri SubjectGroups: CHR compared to HC
Observation: reduced volume AnalysisMethod: vbm Location: left anterior cingulate cortex SubjectGroups: CHR compared to HC
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Reduced GMV in the postcentral gyrus and the anterior cingulate was related to self-reported social impairment across the whole group
Observation: related AnalysisMethod: correlation Location: VBM:postcentral gyrus, clinical:self-reported social impairment SubjectGroups: All subjects
Observation: related AnalysisMethod: correlation Location: VBM:anterior cingulate, clinical:self-reported social impairment SubjectGroups: All subjects
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- Feb 2016
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Structural magnetic resonance images (MRIs) were acquired on a 1.5 Tesla, General Electric Signa Scanner.
MRI Acquisition details: Field: 1.5T Manufacturer: GE Model: Signa
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29 healthy controls (HC)
DiagCode: HC N:29
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20 with SZ
DiagCode: SZ N: 20
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19 with BPD with psychosis
DiagCode: BPDwPSY N: 19
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Thirty-five youths with DSM-IV BPD without psychosis
DiagCode: BPDwoPSY N: 35
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neurological examination, and cognitive testing
More clinical acquisition details
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structured and clinical interviews
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- Aug 2015
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jonudell.net jonudell.net
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VBM detected significant tissue changes within the substantia nigra, midbrain and dentate together with significant cerebellar atrophy in patients (FWE, p < 0.05).
Observation: significant tissue changes AnalysisMethod: vbm Location: substantia nigra SubjectGroups: FTL compared to CTL Observation: significant tissue changes AnalysisMethod: vbm Location: midbrain SubjectGroups: FTL compared to CTL Observation: significant tissue changes AnalysisMethod: vbm Location: dentate SubjectGroups: FTL compared to CTL Observation: decrease AnalysisMethod: vbm Location: cerebellum SubjectGroups: FTL compared to CTL
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- Jul 2015
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jonudell.net jonudell.net
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There were no differences between groups with VBR.
Observation: no difference AnalysisMethod: vbr Location: all brain SubjectGroups: FTL compared to CTL
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voxel-based relaxometry (VBR)
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Voxel-based morphometry (VBM)
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Unified Huntington's Disease Rating Scale (UHDRS)
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Unified Dystonia Rating Scale (UDRS)
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3D-T1w
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quantitative T2 whole brain
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Iron deposition in the caudate head and cavitation in the lateral globus pallidus correlated with UDRS score (p < 0.001).
Observation: significant (p < .001) AnalysisMethod: correlation Location: iron deposition: Caudate head, UDRS SubjectGroups: FTL Observation: significant (p < .001) AnalysisMethod: correlation Location: cavitation: lateral globus pallidus, UDRS SubjectGroups: FTL
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10 clinically symptomatic patients with the 460InsA FTL mutation and 10 age-matched controls
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