798 Matching Annotations
  1. Sep 2020
    1. Biological Data Science November 4 - 6, 2020 Virtual

      Biological Data Science; November 4 - 6, 2020; Virtual Meeting

    1. Addressing Neuroimaging Challenges Across Populations and Settings

      Addressing Neuroimaging Challenges Across Populations and Settings; September 21-22, 2020; Virtual only via tele/videoconference

  2. Aug 2020
    1. Beyond Statistical Significance: Finding Meaningful Effects

      Beyond Statistical Significance: Finding Meaningful Effects; Sept 2, 2020, 10am-6pm ET; Virtual Meeting

    1. Workshop On Open Citations And Open Scholarly Metadata; 9 Sep 2020, 15-18 CET; Online Event

    1. Big Neuroscience Data: Opportunities and Challenges

      Big Neuroscience Data: Opportunities and Challenges; 1:30 AM – 3:30 AM EDT Tuesday Sep 1st, 2020; On Line

  3. Jul 2020
    1. voxel-based morphometry

      As a paper that cites 'voxel-based morphometry' as a technique, it is a candidate for the Monthly Morphometry Report. Identified in auto-search 7/11/15.

    2. progressive supranuclear palsy (PSP)

      Diagnosis Term: progressive supranuclear palsy: http://www.ncbi.nlm.nih.gov/mesh/68013494

    3. Parkinson's disease (PD)

      Diagnosis Term: Parkinson's disease: http://www.ncbi.nlm.nih.gov/mesh/68010300

    4. basal ganglia

      Anatomic Term:

    5. cortical motor areas

      anatomic term

    6. A functional magnetic resonance imaging (fMRI) force production paradigm

      fMRI task statement

    7. We found that PSP and PD share reduced functional activity of the basal ganglia and cortical motor areas, but this is more pronounced in PSP than in PD.

      Result statement: fMRI

    8. In PSP the frontal regions are underactive

      result statement: fMRI

    9. the posterior parietal and occipital regions are overactive as compared with controls and PD

      result statement, referring to in PSP: fMRI

    10. Crus I and lobule IX are hyperactive in PSP only

      result statement: fMRI

    11. Reductions in gray and white matter volume are specific to PSP

      result statement: vbm

    12. lobules I through IV, V, and VI of the cerebellum are hypoactive in PSP and PD

      result statement: fMRI

    13. frontal regions

      anatomic term, related to a finding

    14. posterior parietal

      anatomic term, related to a finding

    15. occipital regions

      anatomic term, related to a finding

    16. lobules I through IV, V, and VI of the cerebellum

      anatomic terms, related to a finding

    17. Crus I

      anatomic term related to a finding

    18. lobule IX

      anatomic term, related to a finding

    19. caudate

      anatomic term, result, prediction

    20. superior frontal gyrus

      anatomic term, result, prediction

    21. the functional status of the caudate as well as the volume of the superior frontal gyrus predict clinical gait and posture measures in PSP

      finding statement: parameter (clinical feature) prediction

    22. clinical gait

      clinical feature

    23. posture

      clinical feature

    24. MMR Summary:

      See also: https://www.nitrc.org/plugins/mwiki/index.php/mmr:26148135

      Diagnostic Groups: PSP, PD & CTL

      Methods: VBM, fMRI (force production paradigm)

      Findings:

      fmri 1) We found that PSP and PD share reduced functional activity of the basal ganglia and cortical motor areas, but this is more pronounced in PSP than in PD.

      fmri 2) In PSP the frontal regions are underactive

      fmri 3) [In PSP] the posterior parietal and occipital regions are overactive as compared with controls and PD

      fmri 4) lobules I through IV, V, and VI of the cerebellum are hypoactive in PSP and PD

      fmri 5) Crus I and lobule IX are hyperactive in PSP only

      vbm 1) Reductions in gray and white matter volume are specific to PSP

      clinical 1) status of the caudate as well as the volume of the superior frontal gyrus predict clinical gait and posture measures in PSP

    1. Neuroferritinopathy

      disease term

    2. 3D-T1w and quantitative T2 whole brain MRI scans

      acquisition details

    3. 10 clinically symptomatic patients with the 460InsA FTL mutation and 10 age-matched controls

      Subject groups: 10 FTL 10 CTL

    4. Voxel-based morphometry (VBM)

      Analysis method: VBM. MMR Candidate

    5. voxel-based relaxometry (VBR)

      Analysis method

    6. Clinical assessment using the Unified Dystonia Rating Scale (UDRS) and Unified Huntington's Disease Rating Scale (UHDRS) was undertaken in all patients

      Clinical measures

    7. Iron deposition in the caudate head and cavitation in the lateral globus pallidus correlated with UDRS score (p < 0.001).

      Result statement 2:

      Finding: significant What: correlation With: iron deposition: caudate, clinical: UDRS Who: all subjects

      Finding: significant What: correlation With: cavitation: lateral globus pallidus, clinical: UDRS Who: all subjects

    8. There were no differences between groups with VBR

      Finding statement 3:

      Finding: no difference What: VBR With: all regions Who: FTL versus CTL

    9. Voxel-based analysis in neuroferritinopathy expands the phenotype and determines radiological correlates of disease severity.
    10. VBM detected significant tissue changes within the substantia nigra, midbrain and dentate together with significant cerebellar atrophy in patients (FWE, p < 0.05)

      Result statement 1: Finding: 'significant tissue changes' Analysis: vbm Location: 'substantia nigra, midbrain and dentate' Groups: FTL compared to CTL

      Finding Observation Measure Locations/Measures Group/Comparison vbm 1 significant tissue changes vbm substantia nigra FTL relative to CTL vbm 1 significant tissue changes vbm midbrain FTL relative to CTL vbm 1 significant tissue changes vbm dentate FTL relative to CTL vbm 1 decrease vbm cerebellum FTL relative to CTL

      Finding: 'atrophy' (volume reduction) Analysis: vbm Location: 'cerebellum' Groups: FTL compared to CTL

    1. voxel-based morphometry
    2. clinical data
    3. depressive patients without anxiety disorder (DP group, n = 18)
    4. The DP group showed decreased GMV in the left insula (INS) and left triangular part of the inferior frontal gyrus when compared to the NC group.

      Observation: Decreased Volume AnalysisMethod: volume Location: Left Insula SubjectGroups: DP compared to NC

      Observation: Decreased Volume AnalysisMethod: volume Location: left triangular part of the inferior frontal gyrus (pars triangularis) SubjectGroups: DP compared to NC

    5. The DPA group showed greater GMV in the midbrain, medial prefrontal cortex, and primary motor/somatosensory cortex when compared to the NC group

      Observation: Increased Volume AnalysisMethod: volume Location: midbrain SubjectGroups: DPA compared to NC

      Observation: Increased Volume AnalysisMethod: volume Location: medial prefrontal cortex SubjectGroups: DPA compared to NC

      Observation: Increased Volume AnalysisMethod: volume Location: primary motor/somatosensory cortex SubjectGroups: DPA compared to NC

    6. the DPA group showed greater GMV than the DP group in the frontal, INS, and temporal lobes

      Observation: Increased Volume AnalysisMethod: volume Location: frontal lobe SubjectGroups: DPA compared to DP

      Observation: Increased Volume AnalysisMethod: volume Location: Insula SubjectGroups: DPA compared to DP

      Observation: Increased Volume AnalysisMethod: volume Location: temporal lobe SubjectGroups: DPA compared to DP

    7. Most gray matter anomalies were significantly correlated with depression severity or anxiety symptoms.

      Observation: significant AnalysisMethod: correlation Location: Volume:most gray matter anomalies, Clinical: depression severity or anxiety symptoms SubjectGroups: DPA and DP

    8. region-of-interest analyses of gray matter volume (GMV)
    9. normal controls (NC group, n = 28)
    10. depressive patients with anxiety disorder (DPA group, n = 20)
    1. clinical high risk (CHR) for psychosis
    2. self-reported and interviewer-rated measures of social functioning
    3. voxel based morphometry (VBM)
    4. the CHR group had less GMV in the left postcentral gyrus, bilateral parahippocampual gyri, and left anterior cingulate cortex

      Observation: reduced volume AnalysisMethod: vbm Location: left postcentral gyrus SubjectGroups: CHR compared to HC

      Observation: reduced volume AnalysisMethod: vbm Location: bilateral parahippocampual gyri SubjectGroups: CHR compared to HC

      Observation: reduced volume AnalysisMethod: vbm Location: left anterior cingulate cortex SubjectGroups: CHR compared to HC

    5. Reduced GMV in the postcentral gyrus and the anterior cingulate was related to self-reported social impairment across the whole group

      Observation: related AnalysisMethod: correlation Location: VBM:postcentral gyrus, clinical:self-reported social impairment SubjectGroups: All subjects

      Observation: related AnalysisMethod: correlation Location: VBM:anterior cingulate, clinical:self-reported social impairment SubjectGroups: All subjects

    1. In summary, we found that human males of all ages exhibit a larger HCV than females, but adjusting for individual differences in TBV or ICV results in no reliable sex difference. The frequent claim that women have a disproportionately larger hippocampus than men was not supported
    1. adolescent patients with severe MDD (n=20, mean age=16.0, range=15-18 years)

      Patient Group

    2. control sample of matched healthy adolescents (n=21, mean age= 16.6, range=15-18 years

      Control group

    3. Structural MRI data were analyzed using voxel-based morphometry (VBM)

      Morphometry Method

    4. MDD patients showed smaller hippocampal volumes compared to healthy adolescents.

      Result 1

    5. Higher levels of childhood maltreatment were associated with smaller hippocampal volumes in both depressed patients and healthy controls

      Result 2

    1. brain MRI scans at two time points 24 months apart

      Scan Interval

    2. sustained abstainers/light drinkers (N = 45)

      Group 1

    3. sustained heavy drinkers (N = 84)

      Group 2

    4. Gray matter volumetric change (GMV-c) maps were derived using the longitudinal DARTEL pipeline as implemented in SPM12

      Method SPM

    5. significant decline in GMV in both groups across the 2 year followup period

      Result 1

    6. tissue loss in the sustained heavy drinking group was more significant, larger per region, and more widespread across regions compared to abstainers/light drinkers

      Result 2

    1. 106 children (M = 10 years 1 month, SD = 16 months; 40 females) enrolled in primary school: 57 were healthy very preterm children (10 children born 24-27 completed weeks' gestation (extremely preterm), 14 children born 28-29 completed weeks' gestation, 19 children born 30-31 completed weeks' gestation (very preterm), and 14 born 32 completed weeks' gestation (moderately preterm)) all born appropriate for GA (AGA) and 49 term-born children

      Groups

    2. voxel-based morphometry

      Method

    3. children born <28 completed weeks' gestation had less gray matter volume (GMV) and white matter volume (WMV) and poorer cognitive functions including decreased full scale IQ, and processing speed

      Result 1

    4. Differences in GMV partially mediated the relationship between GA and full scale IQ in preterm born children.

      Result 2

    1. We analyzed magnetic resonance imaging (MRI) data from a large longitudinal sample (270 participants, 678 scans) using an automated segmentation tool and mixed models to delineate the development of hippocampal subregion volumes from childhood to adulthood.
    1. average neuronal density of the same 60 loci was significantly higher in the male group than in the female group, and the corresponding mean male-to-female ratios were 1.18 in the right and 1.13

      neuronal density difference

    2. cortical thickness of the 60 loci examined was similar in males and females

      No Thickness difference

    1. Overall, there is increasing evidence that specific features (for example, functional connectivity, gray matter volume) of brain regions comprising the salience and default mode networks can be used to discriminate ASD from typical development.

      Conclusion 1

    2. At present, however, the field has yet to identify reliable and reproducible biomarkers for these disorders, and must address issues related to clinical heterogeneity, methodological standardization and cross-site validation before further progress can be achieved.

      Conclusion 2

  4. Jun 2020
  5. May 2020
  6. Apr 2020
  7. Mar 2020
    1. EEGLAB 2020

      EEGLAB 2020; MAY 27 - JUNE 5, 2020; UC SAN DIEGO SUPERCOMPUTER CENTER

  8. Feb 2020
    1. Machine Learning for Healthcare 2020; August 6-8, 2020; Durham, NC, USA

    1. FSCI2020 - August 3 - 7 - UCLA - Los Angeles, California USA

      FSCI2020; August 3 - 7, 2020; Los Angeles, CA USA

  9. Jan 2020
    1. NLM Reproducibility Workshop Menu About Dates

      NLM REPRODUCIBILITY in Bioinformatics WORKSHOP; May 15 – May 17, 2019; Bethesda, MD USA

    1. SPM8

      Tool

    2. VBM8

      Tool

    3. ABIDE

      Data Source

    4. Total brain and grey matter volumes were enlarged by approximately 1–2 % in ASD; however, the effect reached statistical significance in only the All Subjects cohort.

      Claim

    1. NIH Workshop on the Role of Generalist Repositories to Enhance Data Discoverability and Reuse; February 11–12, 2020; Bethesda, MD USA

    1. FENS Forum of Neuroscience; 11-15 July, 2020; Glasgow, UK

    1. San Francisco Brainhack 2020; February 20-21, 2020; San Francisco, CA, USA

    1. Society of Biological Psychiatry Annual Meeting; April 30-May 2, 2020; New York, NY

  10. Dec 2019
    1. IBRO-RIKEN CBS Summer Program 2020; Intern Course: June 18 - August 21, 2020, Lecture Course: June 22 - 26, 2020; Saitama JAPAN

    1. "As much as I care what the phone call contained, I care more that my 401(k) is growing, because I have a child to put through college." Kim Alfano

      This seems to me as a classic example of 'the ends justify the means'.

  11. Nov 2019
  12. Oct 2019
    1. The over-arching goal of this NIDA/NIMH R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nation’s biomedical, behavioral and clinical research needs in the use of ABCD data

      overarching aim

    1. Tuesday, October 29: 11 am – 12 pm

      OpenNeuro Webinar; Tuesday, October 29: 11 am – 12 pm PDT

    2. OpenNeuro Webinars; Thursday, October 24: 10 am – 11 am PDT

  13. Sep 2019
    1. not limited

      limits?

    2. letter of intent is not required

      LOI not required

    3. Indirect Costs (also known as Facilities & Administrative [F&A] Costs) are reimbursed at 8% of modified total direct costs (exclusive of tuition and fees and expenditures for equipment)

      capped IDR

    4. Expenses for foreign travel must be exceptionally well justified.

      foreign travel

    5. maximum project period is 2 years

      duration

    6. Funds Available and Anticipated Number of Awards The following NIH components intend to commit the following amounts in FY 2020: NIDA, $100,000, 1-2 awards NIMH, $200,000, 1-2 awards

      funds

    7. Technology Development

      encouragement areas

    8. Hypothesis Testing

      encouragement areas

    9. areas

      encouragement areas

    10. overall goals of this initiative are: Widening use of the ABCD dataset Enhancing rigor and reproducibility towards better predictive models Facilitating collaboration between clinical and computational researchers on normative and psychopathological neurodevelopment.

      overall goals

    11. Applications proposing prediction of outcomes within the baseline assessment (e.g., predictiing impulsivity scores at the baseline timepoint from neuroimaging measures) are encouraged to explicitly address validation strategies

      encouragement for validation

    12. Applications emphasizing the development of predictive models for identifying group/individual differences, with the overarching goal of predicting behavioral and clinical outcomes in future timepoints

      particular encouragement

    13. purpose of this FOA is to invite applications that involve research education on the use of ABCD data through meetings/workshops involving 1. Advanced seminars relevant to analysis of ABCD data, and 2. Hands on collaborative- or competition-style use of the ABCD dataset.

      purpose

    14. Two types of events are the focus of this initiative. The first includes competitive events where multiple research teams are pitted against each other towards a common challenge. The second includes collaborative events ranging from traditional workshops aimed at analysis-related training to hackathons or codeathons – where multiple participants gather to engage in collaborative computer programming.

      event types

  14. nda.nih.gov nda.nih.gov
    1. and running the .exe file.

      Well, not on MAC (or Linux). Install the package in the 'usual' fashion for your system...

  15. Aug 2019
    1. slower

      Slower, meaning 20 minutes using 7 cores of an 8 vcore MacBook Pro Intel Core i7...

  16. Jul 2019
  17. Jun 2019
  18. May 2019