5 Matching Annotations
  1. Sep 2024
  2. hypothes.is hypothes.is
    Hypothesis
    1
    1. Gharibsulton 17 Sep 2024

      Then let him do so. He cannot surprise me.

      Prometheus is fearless he will not be surprised by other tortures that Zeus will conduct for him. Hermes notify him that Zeus could inflict pains worse than those he is suffering right now although Prometheus is plucky and perseverant by nature
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    hypothes.is/groups/xd9rPMRz/fys-i-fall-2024
  3. Apr 2022
  4. pioneerworks.org pioneerworks.org
    Scientology's Lonely Turf War
    1
    1. chrisaldrich 08 Apr 2022
      If by the ’90s, psychiatry had not totally succeeded in winning the public’s belief in its beneficence, there was at least widespread consensus that mental illnesses were disease entities, with as much of a biological basis as cancer or diabetes.

      No mention of the dad-nextdoor psychiatrist Dr. Jason Siever portrayed by Alan Thicke on the popular television show Growing Pains that may have helped to calm some of the furor from 1985-1992?

      Growing Pains psychiatry Alan Thicke
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    pioneerworks.org/broadcast/scientology-psychiatry/
  5. Sep 2021
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PAINS in the Assay: Chemical Mechanisms of Assay Interference and Promiscuous Enzymatic Inhibition Observed during a Sulfhydryl-Scavenging HTS
    2
    1. zhentg 19 Sep 2021

      this paper described some hit compounds that interfere with the assay components. some compounds react with thiol, and their SAR is reported.

      PAINS covalent warhead
    2. zhentg 19 Sep 2021
      Significant resources in early drug discovery are spent unknowingly pursuing artifacts and promiscuous bioactive compounds

      PAINS=artifacts and promiscuous bioactive compounds

      PAINS
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    ncbi.nlm.nih.gov/pmc/articles/PMC4360378/
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Assay Guidance Manual
    1
    1. zhentg 16 Sep 2021

      Assay guidance

      assay HTS PAINS
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    ncbi.nlm.nih.gov/books/NBK53196/