Tests performed: Haemostatic tests ristocetin-induced platelet aggregation plasma VWF antigen VWF risocetin cofactor VWF FVIII-binding capacity VWF multimers and FVIII activity DDAVP test Concentration timecourses

sequencing from genomic DNA performed and reported in 2011

cDNA analysis

Real-time-PCR analysis

long PCR

Ellman assay (quantifying sulfhydryls)

Dynamic light scattering measurements

circular dichroism

ADAMTS13 proteolysis assay

ADAMTS13-VWF binding assay

Useful discussion on the pros and cons!

Beauté, J., Adlhoch, C., Bundle, N., Melidou, A., & Spiteri, G. (2021). Testing indicators to monitor the COVID-19 pandemic. The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(21)00461-8

Surkova, E., Nikolayevsskyy, V., Drobniewski, F. (2020). False-positive COVID-19 results: hidden problems and costs. The Lancet Respiratory Medicine. https://doi.org/10.1016/S2213-2600(20)30453-7