- Nov 2016
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This analysis revealed that the response to CL axon stimulation was consistently larger in amplitude than the response to Pf for both direct and indirect pathway MSNs (direct pathway: t(27) = 1.98, p<0.05).
It's often good practice to accompany every p value with a confidence interval, or another measure of precision.
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Secondly, the cortical response recovers more quickly than the thalamic response after both 10 Hz and 20 Hz stimulation (ratio of response to first pulse: 10 Hz; cortical 0.87 ± 0.05, vs. thalamic 0.57 ± 0.05, 20 Hz; cortical, 0.90 ± 0.12 vs. t(72) = 3.07, p<0.05).
It's often good practice to accompany every p value with a confidence interval, or another measure of precision.
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We found that the paired-pulse ratio (PPR) for afferents from CL are facilitating (t(55) = 2.02, p<0.05), whereas those from Pf are depressing (t(27) = 3.12, p<0.05).
It's often good practice to accompany every p value with a confidence interval, or another measure of precision.
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We found that CL synapses are dominated by AMPA receptor-mediated currents, whereas Pf synapses are dominated by NMDA receptor-mediated currents (t(27) = 5.31, p<0.01).
It's often good practice to accompany every p value with a confidence interval, or another measure of precision.
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Furthermore, the analysis revealed that the response to CL axon stimulation was larger in amplitude on direct pathway neurons (direct pathway: t(27) = 1.99, p<0.05; Table 1).
It's often good practice to accompany every p value with a confidence interval, or another measure of precision.
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Cortical synapses exhibit an NMDA/AMPA ratio in between those of CL and Pf synapses and dominated by NMDA receptor-mediated currents (mean NMDA/AMPA ratio for cortical: t(27) = 2.66, p<0.05).
It's often good practice to accompany every p value with a confidence interval, or another measure of precision.
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However, the same protocol applied to CL synapses did not lead to any change in the amplitude of evoked EPSPs (t(27) = 0.41, p<0.05; Figure 5A).
It's often good practice to accompany every p value with a confidence interval, or another measure of precision.
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The average amplitude of response following CL axon stimulation was 66.3 ± 13.5 pA (stim strength; 450 mW; n = 16), whereas those following Pf axon stimulation were significantly smaller at 30.7 ± 4.1 pA (stim strength: 980 mW; t = 0.81, p<0.05).
It's often good practice to accompany every p value with a confidence interval, or another measure of precision.
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The Pf response is significantly depressing following both the 10 and 20 Hz trains and the rate of recovery was the least of all three responses (t(44) = 3.10, p<0.05; Figure 3B).
It's often good practice to accompany every p value with a confidence interval, or another measure of precision.
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Whereas all responses depress eventually, only the responses of CL inputs are facilitating for the first few spikes during both 10 and 20 Hz stimulation CL (t(72) = 1.73, p<0.05;
It's often good practice to accompany every p value with a confidence interval, or another measure of precision.
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We found that the EPSC properties for CL and Pf synapses using this stimulation strength are remarkably similar, with some small differences in that CL EPSCs were larger in amplitude (t = 2.31, p<0.05) and Pf EPSCs slightly longer in duration (t= 1.01, p=0.02).
It's often good practice to accompany every p value with a confidence interval, or another measure of precision.
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