This pattern implies that in these patients, it is not the telomerase mutation itself but the short telomeres that determine the severity of the disease.14,24,26
Implicating short telomeres (TBD) is the underlying mechanism of disease
11 Matching Annotations
- Oct 2026
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www-nejm-org.libproxy.lib.unc.edu www-nejm-org.libproxy.lib.unc.edu
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www-nature-com.libproxy.lib.unc.edu www-nature-com.libproxy.lib.unc.edu
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mice have short life spans (~2–3 years), residual Tert expression in many adult tissues (discussed below)8, and, in the common Mus musculus laboratory strain, long telomeres (~20–65 kb)9
Mouse models should potentially be downgraded given the significant difference in telomere biology
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Since then, 16 additional TBD-causing genes have been identified (Table 1)
Important Table of 16 known telomere biology disorder linked genes with synopses of associated diseases and case counts
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www-ncbi-nlm-nih-gov.libproxy.lib.unc.edu www-ncbi-nlm-nih-gov.libproxy.lib.unc.edu
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Telomerase and Idiopathic Pulmonary Fibrosis
PMID 22079513
Disease Idiopathic pulmonary fibrosis
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The consequences of telomerase deficiency were studied in model organisms before telomerase mutations were discovered in the setting of human disease[18, 19]
Animal Models telomerase deficiency was studied in mouse models prior to their discovery in association with human disease, with dyskeratosis congenita being the first to be associated with TBD
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- Jun 2024
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git.doit.wisc.edu git.doit.wisc.edu
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why slow path vs fast path? policy?
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is there a policy decision here? Why would we choose to use lockless vs. not?
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- Jan 2021
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www.userfocus.co.uk www.userfocus.co.uk
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I really found this exercise very useful to get to know properly your team members, sometimes we feel frustrated because we don't feel comfortable working with some people, this definitely helps a lot.
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People don’t want to think too hard about your customer experience because thinking is hard work.
As a user myself, I can totally relate to this article. I tend to stick to simple things in life, especially when it comes to technology. In the world that we live in, we don't have any time to actually sit and figure out an app or a website: we are constantly in a hurry and already have too many other things going on. We use so many apps and scroll down on so many websites per day, switching from one to another. So yes, I believe that when creating a user experience you have to take into consideration how simple it will be for the users.
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- Mar 2019
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Hadi
TBD
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- Jul 2016
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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When FA and ADC in forceps major were entered, FA was still significantly related to incongruent RT (β = −0.11, P < 0.01), whereas ADC ceased to be significant.
ID: 024 Variable: Incongruent RT Covariate: FA of forceps major, ADC of forceps major *how do we annotate that DTI parameters were included pairwise? does it matter that they were entered pairwise? we have a beta for each FA that varies by its DTI pairing
ID: 025 Variable: Incongruent RT Covariate: FA Beta: -0.11 P: <0.01
ID: 026 Variable: Incongruent RT Covariate: ADC P: insignificant
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