27 Matching Annotations
  1. Mar 2021
    1. Via compression, we connected the insulin tip to a shaft made solely from biodegradable polymers

      Tips are connected to the shaft which consists of very large molecules composed of many repeating subunits.

    2. To demonstrate that the mass distribution affected self-orientation, we showed that the SOMA oriented in 100% of trials, whereas a device of the same shape made solely of PCL only oriented 50% of the time.

      The weight distribution of the SOMA device out performed devices made solely of PCL showing that weight distribution plays a large role in the ability to self orient.

    3. The optimized SOMA shape outperformed both a sphere and ellipsoid made from the same materials with equivalent masses, volumes, and density distributions in two biologically relevant metrics: orientation time and stability.

      When devices with different shapes but the same equivalent mass, volume and density distribution were compared, the SOMA shape was shown to be better at self orienting. This shows that the SOMA shape performs better than the sphere and ellipsoid shapes.

    4. Like the leopard tortoise shell, the corner decreased the applied

      Stability and Change: Crosscutting Concepts: The tortoise has evolved to be able to reorient itself if flipped over. This allows the species to survive over time.

    5. toxicity experiments in rats. No inflammation or signs of toxicity were observed

      Oral administration of the device in single doses and repetitive doses was not seen to be hazardous to rats.

    6. Field’s metal

      Less toxic metal that does not contain lead or cadmium. Instead, Field's metal contains indium.

    7. to produce the low center of mass needed for the SOMA to self-orient.

      A mixture of low and high density materials were used to make the lower portion of the SOMA device.

    8. In vitro studies confirmed that the SOMA oriented most quickly from a 30° and a 135° angle (Fig. 2C). The device did not orient most rapidly between the angles of 45° and 100° in the simulation or at a 90° angle during in vitro experiments because it possessed a corner in this region.

      Experiments confirmed that the device oriented the quickest between the angles of 30° and 135°. The device oriented the slowest between the angles of 45° and 100° or an exact angle of 90°.

    9. When dropped from a series of random orientations, the simulation predicted that the SOMA possessed the lowest mean orientation time.

      When dropped from different angles the simulation predicted that the SOMA device had the fastest average orientation time.

  2. Feb 2021
    1. Our simulation predicted that the SOMA oriented most rapidly between the angles of 0° and 45° and the angles of 100° and 180° measured from the preferred orientation, and it oriented within 100 ms from 85% of all initial positions (Fig. 2B).

      When considering the preferred orientation of the device the SOMA shape was able to self-orient the quickest between the angles of 0° and 45° and the angles of 100° and 180°. This orientation occurs within 100 milliseconds from 85% of all initial positions.

    2. hydroxypropyl methylcellulose

      Non-fermentable semi-synthetic dietary fibre, based on cellulose.

    3. conical structure

      Cone shaped structure.

    4. poly(ethylene) oxide

      Biomaterial with a high molecular weight.

    5. molecular weight

      The ratio of the average mass of one molecule of an element to one twelfth of the mass of an atom of carbon.

    6. overtube

      A protective tube used during endoscopy.

    7. endoscopy

      A procedure used to look inside the body and examine the interior of a hollow organ or body cavity.

    8. ex vivo

      Experimentation done on tissue from an organism in an external environment with minimal alteration of natural conditions.

    9. mucosal

      The inner lining of organs and body cavities such as the stomach.

    10. gastric juice

      A thin, clear, acidic fluid secreted by the stomach glands.

    11. viscosities

      The state of being thick and semifluid in consistency.

    12. excursions

      A deviation from a regular pattern, path, or level of operation.

    13. torque

      A twisting force that causes rotation.

    14. subchronic

      Oral subchronic toxicity refers to adverse effects occurring after repeated administration of a test sample.

    15. acute

      Acute oral toxicity refers to adverse effects following oral administration of a single dose of a substance.

    16. prototyping

      An early sample, model, or release of a product built to test a concept or process.

    17. 316L stainless steel

      Second most common marine grade stainless steel.

    18. polycaprolactone

      Biodegradable polyester with a low melting point of around 60°C.