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e human face and skull is largely genetically determined. However, the genomic basis of craniofacial morphology is incom

California’s

Winter storms

we demonstrate

Here

wastewater injection

increases in deep wastewater

may be related

United States

midwestern

seismicity

distant-acting enhancers

ght, Y. Watanabe, E. Howard, R. L. de Lima, S. Daack-Hirsch, A. Sander, D. M. McDonald-McGinn, E. H. Zackai, E. J. Lammer, A.

Recent observations of large numbers of distant-acting

craniofacial shape through genome-wide association

and targeted deletion experiments to examine the role of distant-acting enhancers in craniofacial development. We identified complex regulatory landscapes consisting of enhancers that drive spatially complex developmental expression patterns. Analysis of mouse lines in which individual craniofacial enhancers had been deleted revealed significant alterations of craniofacial shape, demonstrating the functional importance of enhancers in defining face and skull morphology. These results demonstrate that enhancers are involved in craniofacial development and suggest that enhancer sequence variation contributes to the diversity of human facial morph

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