11 Matching Annotations
  1. Feb 2024
    1. De Bataafse Opstand, ook wel de opstand van de Bataven of opstand van de Batavieren genoemd, was een opstand (69 – 70) van de (vermoedelijk) West-Germaanse Bataven onder leiding van Gaius Julius Civilis in de militaire provincie Neder-Germanië (Germania Inferior)
  2. Mar 2021
    1. Results for individual PALB2 variants were normalized relative to WT-PALB2 and the p.Tyr551ter (p.Y551X) truncating variant on a 1:5 scale with the fold change in GFP-positive cells for WT set at 5.0 and fold change GFP-positive cells for p.Y551X set at 1.0. The p.L24S (c.71T>C), p.L35P (c.104T>C), p.I944N (c.2831T>A), and p.L1070P (c.3209T>C) variants and all protein-truncating frame-shift and deletion variants tested were deficient in HDR activity, with normalized fold change <2.0 (approximately 40% activity) (Fig. 1a).

      AssayResult: 4.9

      AssayResultAssertion: Normal

      StandardErrorMean: 0.08

    2. A total of 84 PALB2 patient-derived missense variants reported in ClinVar, COSMIC, and the PALB2 LOVD database were selected

      HGVS: NM_024675.3:c.3404G>A p.(Gly1135Glu)

    1. Source Data

      AssayResult: 21.7

      AssayResultAssertion: Abnormal

      ReplicateCount: 2

      StandardErrorMean: 1.42

      Comment: Exact values reported in “Source Data” file.

    2. Source Data

      AssayResult: 30.35

      AssayResultAssertion: Abnormal

      ReplicateCount: 2

      StandardDeviation: 3.64

      StandardErrorMean: 2.57

      Comment: Exact values reported in “Source Data” file.

    3. We, therefore, analyzed the effect of 48 PALB2 VUS (Fig. 2a, blue) and one synthetic missense variant (p.A1025R) (Fig. 2a, purple)29 on PALB2 function in HR.

      HGVS: NM_024675.3:c.83A>G p.(Y28C)

    1. Most Suspected Brugada Syndrome Variants Had (Partial) Loss of Function

      AssayResult: 23.1

      AssayResultAssertion: Abnormal

      ReplicateCount: 33

      StandardErrorMean: 3.2

      Comment: This variant had partial loss of function of peak current (10-50% of wildtype), therefore it was considered abnormal (in vitro features consistent with Brugada Syndrome Type 1). (Personal communication: A. Glazer)

    2. we selected 73 previously unstudied variants: 63 suspected Brugada syndrome variants and 10 suspected benign variants

      HGVS: NM_198056.2:c.5126C>T p.(Thr1709Met)

  3. Mar 2018
  4. Oct 2016
  5. Oct 2015
    1. The articles obtained to review Trick Your Brain into Thrift by Paying with Cash by Crack Articles is a theory that can be held at both ends. The articles provided have several brushed details of numerous researches that have been done that links the psychological human being into using credits card. Vis versa there is not much details on how to make, trick, or psychologically change one’s mind into purchasing with cash. The psychological research lead to how one views cash and a credit card or how the individual’s emotions are effected by their economic stand point when making purchases. The types of sources influence by the credit card companies to encouraging the public into using their credit card are endless, but the top mechanism used today is earning money back while spending. A real soother to human ear, when one does not like to see cash disappear from their wallet. Acknowledging, the basis of the title that Cracked Article uses is clearly avoiding using cash. The title shouldn’t be Trick Your Brain into Thrift by Paying with Cash, but the Tricks Your Brain Uses to Have You Pay with Credit Cards or When Not to Shop to Be Thrift.