- Oct 2023
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tinlizzie.org tinlizzie.org
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engineering a safer world it's done by nancy levison who is a aerospace astronautics engineer
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- Sep 2023
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1: Why Do We Need Something Different? Doi: https://doi.org/10.7551/mitpress/8179.003.0004 Open the PDF Link PDF for 1: Why Do We Need Something Different? in another window 2: Questioning the Foundations of Traditional Safety Engineering Doi: https://doi.org/10.7551/mitpress/8179.003.0005 Open the PDF Link PDF for 2: Questioning the Foundations of Traditional Safety Engineering in another window 3: Systems Theory and Its Relationship to Safety Doi: https://doi.org/10.7551/mitpress/8179.003.0006 Open the PDF Link PDF for 3: Systems Theory and Its Relationship to Safety in another window II: STAMP: An Accident Model Based On Systems Theory [ Opening ] Doi: https://doi.org/10.7551/mitpress/8179.003.0029 Open the PDF Link PDF for [ Opening ] in another window 4: A Systems-Theoretic View of Causality Doi: https://doi.org/10.7551/mitpress/8179.003.0008 Open the PDF Link PDF for 4: A Systems-Theoretic View of Causality in another window 5: A Friendly Fire Accident Doi: https://doi.org/10.7551/mitpress/8179.003.0009 Open the PDF Link PDF for 5: A Friendly Fire Accident in another window III: Using STAMP [ Opening ] Doi: https://doi.org/10.7551/mitpress/8179.003.0030 Open the PDF Link PDF for [ Opening ] in another window 6: Engineering and Operating Safer Systems Using STAMP Doi: https://doi.org/10.7551/mitpress/8179.003.0011 Open the PDF Link PDF for 6: Engineering and Operating Safer Systems Using STAMP in another window 7: Fundamentals Doi: https://doi.org/10.7551/mitpress/8179.003.0012 Open the PDF Link PDF for 7: Fundamentals in another window 8: STPA: A New Hazard Analysis Technique Doi: https://doi.org/10.7551/mitpress/8179.003.0013 Open the PDF Link PDF for 8: STPA: A New Hazard Analysis Technique in another window 9: Safety-Guided Design Doi: https://doi.org/10.7551/mitpress/8179.003.0014 Open the PDF Link PDF for 9: Safety-Guided Design in another window 10: Integrating Safety into System Engineering Doi: https://doi.org/10.7551/mitpress/8179.003.0015 Open the PDF Link PDF for 10: Integrating Safety into System Engineering in another window 11: Analyzing Accidents and Incidents (CAST) Doi: https://doi.org/10.7551/mitpress/8179.003.0016 Open the PDF Link PDF for 11: Analyzing Accidents and Incidents (CAST) in another window 12: Controlling Safety during Operations Doi: https://doi.org/10.7551/mitpress/8179.003.0017 Open the PDF Link PDF for 12: Controlling Safety during Operations in another window 13: Managing Safety and the Safety Culture Doi: https://doi.org/10.7551/mitpress/8179.003.0018 Open the PDF Link PDF for 13: Managing Safety and the Safety Culture in another window 14: SUBSAFE: An Example of a Successful Safety Program Doi: https://doi.org/10.7551/mitpress/8179.003.0019 Open the PDF Link PDF for 14: SUBSAFE: An Example of a Successful Safety Program in another window Epilogue Doi: https://doi.org/10.7551/mitpress/8179.003.0020 Open the PDF Link PDF for Epilogue in another window Appendixes A: Definitions Doi: https://doi.org/10.7551/mitpress/8179.003.0022 Open the PDF Link PDF for A: Definitions in another window B: The Loss of a Satellite Doi: https://doi.org/10.7551/mitpress/8179.003.0023 Open the PDF Link PDF for B: The Loss of a Satellite in another window C: A Bacterial Contamination of a Public Water Supply Doi: https://doi.org/10.7551/mitpress/8179.003.0024 Open the PDF Link PDF for C: A Bacterial Contamination of a Public Water Supply in another window D: A Brief Introduction to System Dynamics Modeling Doi: https://doi.org/10.7551/mitpress/8179.003.0025 Open the PDF Link PDF for D: A Brief Introduction to System Dynamics Modeling in another window References Doi: https://doi.org/10.7551/mitpress/8179.003.0026 Open the PDF Link PDF for References in another window Index Doi: https://doi.org/10.7551/mitpress/8179.003.0027 Open the PDF Link PDF
Great resources here
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- May 2022
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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DICER1 syndrome is an autosomal-dominant, pleiotropic, tumor-predisposition disorder arising from pathogenic germline variants in DICER1, which encodes an endoribonuclease integral to processing microRNAs (1).
Gene Name: DICER1 PMCID: PMC5443331 PMID: 28323992 HGNCID: not found Inheritance Pattern: autosomal dominant Disease Entity: thyroid cancer and familial multinodular doiter Mutation: germline loss-of-function mutation Zygosity: not provided Variant: c.1870C>T; p.Arg624a, c.1870C>T; p.Arg624a, c.1870C>T; p.Arg624a, c.1870C>T; p.Arg624a, c.3726C>A; p.Tyr1242a, c.3675C>G; p.Tyr1225a, c.3675C>G; p.Tyr1225a Family Information: 145 individuals with a DICER1 germline mutation and 135 controls from 48 families Case: family members used; both males and females used and no significant differences seen among sex; ages range from 20-40 with carriers being significantly younger than controls; no significant differences seen among ethnicity but participants located from the US, UK, and Great Britain CasePresentingHPOs: thyroid cancer or MNG diagnosis common to those with a DICER! mutation but with no chemotherapy or radiation treatment yet CasePreviousTesting: tested levels of thyroid-stimulating hormone, thyroxine, thyroxine-binding globulin, and serum albumin; thyroid palpation; thyroid ultrasound; Sanger or next-generation sequencing assays gnomAD: n/a Mutation Type: missense
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- Zygosity:notprovided
- FamilyInformation:145individualswithaDICER1germlinemutationand135controlsfrom48families
- InheritancePattern:autosomaldominant
- Variant: c.1870C>T; p.Arg624a, c.1870C>T; p.Arg624a, c.1870C>T; p.Arg624a, c.1870C>T; p.Arg624a, c.3726C>A; p.Tyr1242a, c.3675C>G; p.Tyr1225a, c.3675C>G; p.Tyr1225a
- HGNCID:notfound
- PMID:28323992
- DiseaseEntity:thyroidcancerandfamilialmultinodulardoiter
- MutationType:missense
- Mutation:germlineloss-of-functionmutation
- Gene:DICER1
- PMCID:PMC5443331
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Embryonal rhabdomyosarcoma (ERMS) of the uterus has recently been shown to frequently harbor DICER1 mutations.
HGNCID:
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- Mutation: 5428 G>C
- Variant: Clinvar ID not identified
- Mutation: c5113G>A
- Disease Entity: Embryonal rhabdomyosarcoma (ERMS)
- Mutation: c.5438 A> C
- Family Information: not identified
- GeneName: DICER1
- Mutation: c.4420A>G
- case wt: m&f 0.5-19
- PMID (PubMed ID): 33846547
- Mutation: c.5125G > A
- Zygosity: Some Cases displayed homozygosity
- Mutation: c.3580delA
- Inheritance Pattern: Non- inheritance(DNA methylation)
- case mut: f 28-67
- Mutation: c.4267G>T
- Mutation: c.5428G>T
- pathogenicity: only 2 of 17 patients died from disease
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- Apr 2022
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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DICER1 Syndrome
GeneName: DICER1 PMID: 28323992 PMCID: PMC5443331 *No HGNCID found Inheritance pattern: autosomal-dominant Disease Entity: multinodular goiter and thyroid cancer Mutation: Germline Zygosity: not listed Variant: c.3726C>A; p.Tyr1242a, c.3675C>G; p.Tyr1225a Family Information: 145 individuals with DICER1 germline mutations from 48 family controls (135 individuals) that lacked the DICER1 mutation Case: male and female carriers as well as family members were studied. Ages: 20, 30, and 40 for both populations (DICER1 carriers were significantly younger than controls}. Population from Great Britain, UK, and USA (no significant difference between race, ethnicity, or sex found). CasePresentingHPOs: no previous therapeutic radiation or chemotherapy. Thyroid cancer or MNG diagnoses were likely reported with the DICER1 mutation CasePreviousTesting: Sequencing performed with Sanger or next-generation sequencing assays. DICER1 carriers underwent testing to obtain thyroid-stimulating hormone, thyroxine, thyroxine-binding globulin, and serum albumin levels as well as medical history and physical examinations (+thyroid palpation). Participants were also given thyroid US examinations. gnomAD: n/a Mutation Type: missense
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- Mutation:germline
- Mutationtype:missense
- CasePresentingHPOs:thyroidcancerorMNGdiagnosis
- DiseaseEntity: multinodular goiter and thyroid cance
- CasePreviousTesting:geneticsequencingbloodtestforthyroidhormonesandserumalbuminphysicalsthyroidUSexams
- InheritancePattern:autosomal-dominant
- Zygosity:notlisted
- Variant:c.3726C>A
- Variant:c.3675C>G
- Case:age203040withnosignificantdifferencebetweenraceethnicityorsex
- FamilyInformation:145individualswithDICER1germlinemutationsfrom48familycontrols(135 individuals)thatlackedtheDICER1mutation
- PMID:28323992
- Gene:DICER
- PMCID:PMC5443331
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- Mar 2022
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www.reseau-canope.fr www.reseau-canope.fr
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En somme, les études sur la communication des élèves atteints d’autisme permettent de mettre en évidence l’importance d’un contexte riche en stimulations appropriées (sons et images), mais également une évidente « stabilité » de l’information à décoder, le suivi des émotions des personnages, le rôle de l’imitation dans les apprentissages. Ces résultats encouragent donc l’usage d’outils informatiques adéquats pour améliorer la communication sociale chez les enfants atteints d’autisme.
L'association de deux sujets qui n'ont pas de corrélation vérifiéé, revient dans la conclusion en contradiction avec la conclusion de l'étude de Ramdoss, S et al.
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Nous allons montrer par une courte analyse de quelques études l’impact du travail éducatif informatisé dans l’apprentissage de la communication sociale chez des enfants atteints d’autisme.
En contradiction avec l'hypothèse :
Results suggest that CBI should not yet be considered a researched-based approach to teaching communication skills to individuals with ASD. However, CBI does seem a promising practice that warrants future research. Les résultats suggèrent que le CBI ne devrait pas encore être considéré comme un approche fondée sur la recherche pour enseigner les compétences en communication aux personnes ayant Troubles du Spectre Autistique. Cependant, le CBI semble être une pratique prometteuse qui justifie des recherches futures.
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- Ramdoss, S., Lang, R., Mulloy, A., Franco, J., O’Reilly, M., Didden, R., & Lancioni, G. (2010a). Use of Computer-Based Interventions to Teach Communication Skills to Children with Autism Spectrum Disorders : A Systematic Review. Journal of Behavioral Education, 20(1), 55‑76. https://doi.org/10.1007/s10864-010-9112-7
- Ramdoss, S., Lang, R., Mulloy, A., Franco, J., O’Reilly, M., Didden, R., & Lancioni, G. (2010b). Use of Computer-Based Interventions to Teach Communication Skills to Children with Autism Spectrum Disorders : A Systematic Review. Journal of Behavioral Education, 20(1), 55‑76. https://doi.org/10.1007/s10864-010-9112-7
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- Aug 2021
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sec.report sec.report
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112,661
G&A expenses account for ~14% of Total Revenue
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