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  1. Nov 2021
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial
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    1. Drugs_and_Ethics 17 Nov 2021
      A significant reduction in cognitive fatigue perception and overall FIS-40 score (p < 0.001 and p = 0.022, respectively)

      Given how cheap and easy this intervention is, I'd say this is adequate evidence that all ME/CFS patients should be taking these supplements. Moreover. given that the p-value is so low, it is almost certain to be replicated.

      ME/CFS Q10 NADH placebo human blinded
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    ncbi.nlm.nih.gov/pmc/articles/PMC8399248/