8 Matching Annotations
  1. Aug 2021
    1. Conclusions: Chronic vitamin E administration improves the ratio of cardiac sympathetic to parasympathetic tone in patients with type 2 diabetes. Such an effect might be mediated by a decline in oxidative stress.

      This is plausibly the reason why antioxidants enhance sleep. Though it is likely that there are other mechanisms as well, such as reduced neuroinflammation. Come to think of it, given that ME/CFS appears to be caused by high sympathetic tone during sleep, antioxidants are the perfect treatment. Antioxidants are proven in placebo-controlled trials to help with sleep in healthy subjects and insomniacs alike. I doubt that antioxidants can cure ME/CFS, but I'm confident they will help.

  2. Apr 2021
    1. What you Need to Know about Loneliness

      18:03 Loneliness leads to microarousals. Could this be a potential root cause of ME/CFS.

  3. Mar 2019
    1. CONCLUSION: HSP could have the ability of antifatigue and improve the immunomodulation effect in mice.

      I'd like to see a trial of hemp protein for chronic fatigue syndrome.

  4. Jan 2019
    1. RESULTS: At night (sleep), HR, mean arterial blood pressure and diastolic blood pressure were significantly higher in CFS patients as compared with controls (p < 0.01). During daytime, HR was significantly higher among CFS patients (p < 0.05), whereas blood pressures were equal among the two groups.

      I find the increased nighttime blood pressure suprising. Increased heart rate, on the other hand, is exactly what I might expect. Given that it is diastolic pressure that is elevated, I take it that the increased heart rate is the cause. If not, it could be that a stressor, like a hypopnea, is the underlying cause.

  5. Nov 2018
    1. The proportion of women with UARS is also significantly higher than for OSAS

      This further supports the link to ME/CFS. The ratio in the referenced study is about 2.5 to 1: female to male.

    2. The most frequent symptoms are excessive daytime sleepiness, fatigue and sleep fragmentation. However, UARS patients also present significantly more often with sleep-onset and sleep-maintenance insomnia, postural hypotension, headaches, gastroesophageal reflux, irritable bowel syndrome, anxiety and alpha-delta sleep

      This makes Upper Airway Resistance Syndrome a prime suspect for ME/CFS. I presents many of the same symptoms, and may be the instigating factor. That does not mean, however, that UARS is the only cause, nor that treating UARS is necessarily sufficient to treat ME/CFS; a feedback loop may mean that other factors must be attended to.

  6. Oct 2018
    1. CONCLUSIONS: These data demonstrate improvement in FM-related sleep dysfunction with pregabalin therapy. The majority of this benefit was a direct effect of pregabalin on the patients' insomnia, while the remainder occurred through the drug's analgesic activity.

      Since the pain is caused be SWS interference, it might be difficult to disentangle cause and effect.

  7. Jan 2018