46 Matching Annotations
  1. Jan 2025
    1. Numinous - picked up of course, by Jung - to describe what the original, the primordial experience of the numinous is

      for - definition - numinous - primordial - Otto - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

    2. Gnosticism, of course, is a way of trying to awaken us to the primordiality of, and the mystery in some important sense, of Religio.

      for - definition - Gnosticism - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

    3. What we do when we go into a sacred setting, is we play with Meta-… We have psycho-technologies - and I'll come back and give a [-] clear definition as we work that out, of a psycho-technology - but we have psycho-technologies that allow us to do this serious play with sacredness so that we are constantly being homed against horror.

      for - in other words - going nto a sacred setting - is a counter force to alienation - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

    4. horror would be to be overwhelmed by loneliness. Would be overwhelmed by homesickness, cultural shock and a tremendous sense of alienation, absurdity, and anxiety.

      for - definition - horror - alienation - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

    5. if you go to another culture and you don't go through the participatory transformation, right? If you don’t, and you're just experiencing culture shock - domicide - the agent arena relationship isn't in place! Then none of those other meaning systems can work for you. There'll be absurd. They won't make sense. That's what he means by it being a Meta-Meaning system.

      for - adjacency - culture shock - example of domicide - when the agent-arena relationship is not in place - participatory knowing - meta-meaning system - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

    6. that deep loneliness, that deep homesickness, that deep cultural shock, that's domiciled.

      for - definition - domicile - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

    7. to reflect upon, to celebrate and enact Religio is to fundamentally enhance our agency, the disclosure of the world and our connectedness to it. And what else could be more valuable to us? What else could be more valuable to us?

      for - quote - to make significant, to reflect upon, to celebrate and enact Religio is to fundamentally enhance our agency, the disclosure of the world and our connectedness to it. And what else could be more valuable to us? What else could be more valuable to us? - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

      quote - to make significant, to reflect upon, to celebrate and enact Religio is to fundamentally enhance our agency, the disclosure of the world and our connectedness to it. And what else could be more valuable to us? What else could be more valuable to us? - John Vervaeke - (see below) - And we do this, I would argue, - for the very good reason that - to make significant, - to reflect upon, - to celebrate and enact Religio - is to fundamentally - enhance our agency, - the disclosure of the world and our connectedness to it. - And what else could be more valuable to us? What else could be more valuable to us?

    8. I’m always seeing by means of the I”. It is phenomenologically mysterious to [us], but it doesn't mean that I'm unaware of it. I always have - to use older language, from the course I mean - I always have a subsidiary awareness. I'm always aware through my “I” of my “me”. I'm always aware through my framing of my framed. I'm not completely out of touch with it. It is not inaccessible to me, but I cannot focalised it.

      for - quote - subsidiary awareness - I cannot finalize it but can be aware of it - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke - definition - subsidiary awareness - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

      quote - subsidiary awareness - I cannot finalize it but can be aware of it - John Vervaeke - (see below) - I’m always seeing by means of the I”. - It is phenomenologically mysterious to [us], but - it doesn't mean that I'm unaware of it. - I always have a subsidiary awareness. - I'm always aware through my “I” of my “me”. - I'm always aware through my framing of my framed. - I'm not completely out of touch with it. - It is not inaccessible to me, - but I cannot focalised it.

    9. I can't use the grammar of subjects and objects, subjects and predicates, conceptual categories to talk about this (RR transjectivity) in the sense of exemplifying it!

      for - definition - relevance realisation transjectivity - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

    10. The machinery of Relevance Realization is in that sense, deeply phenomenologically mysterious to me.

      for - quote - the machinery of relevance realisation is deeply phenomenologically mysterious to me - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

    11. But what is precisely not inside the frame is the framing process

      for - adjacency - framing process is outside of ANY frame we create -- eye cannot see itself - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

    12. Relevance Realization is taking place at a level fundamentally deeper than the level of belief.

      for - Relevance realization is pre-conceptual - it takes place at a level deeper than the level of beliefs - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke - to - YouTube conversation - Micheal Levin, John Vervaeke, Gregg Henrique - 2024 // ,- comment - In light of studying a John's concept of relevance realisation now, - after partially annotating the - Micheal Levin, - John Vervaeke, - Gregg Henrique - YouTube conversation, I should return to that annotation to - finish it and - take a more critical look for comparison between - Micheal Levin's goal oriented behaviour definition of life that drives and expanding cognitive light cone and - John Vervaeke's relevance realisation

      to - YouTube conversation - Micheal Levin, John Vervaeke, Gregg Henrique - 2024 - https://hyp.is/go?url=https%3A%2F%2Fwww.youtube.com%2Fwatch%3Fv%3DrAlmzRTbGDE&group=world

    13. the death example actually points to something more primordial! It points to the fact that I can never make a focal object of my framing, my capacity for Relevance Realization. I mean, Perspectively. What I mean by that is whenever I am thinking or doing anything, [-] it's always framed because if I'm unframed, I'm facing combinatorial explosion, which is not intelligible to me.

      for - key insight / adjacency - relevance realization - I can never make a focal object of my framing, my capacity for relevance realization - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke - adjacency - focal object - framing - relevance realization - attention - intention - language - gestalt - infinite nesting - design - aspectualize - - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

      adjacency - between - focal object - framing - relevance realization - attention - intention - language - gestalt - infinite nesting - design - aspectualize

      adjacency - between - focal object - framing - relevance realization - attention - intention - language - gestalt - infinite nesting - design - aspectualize

      adjacency - between - focal object - framing - relevance realization - attention - intention - language - gestalt - infinite nesting - design - aspectualize - adjacency relationship - As soon as we give attention to one aspect of our gestalt reality, we aspectualize, we frame - All of the below involve framing / aspectualizing - thinking - language use - design

    14. it is phenomenologically impossible for me to Perspectively know what it is like to be dead, because whenever I try to conjure up a frame (indicates the smallest, central box in the diagram), “Oh, I'm in a dark room! But wait, I'm still there in the dark room. There's the hereness and the nowness… Oh well, then I'm nowhere! Well, then I'm just an empty…!” No matter what I do, I can't get a framing that has within it my own non-existence, perspectively.

      for - example - what's it like to be dead? - phenomenologically impossible for me to perspectively know what it's like to be dead - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

    15. my insight goes from a reframing to a transframing, because I stopped having insights about my focal problem [and] I start getting an insight, not about just the problem or the world, I also - remember of the sensibility transcendence; I'm also getting an insight into the inadequacies of my style of framing, my way of framing - I'm getting a trans-framing happening.

      for - definition - transframing - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

    16. article there called “A Secular Wonder”

      for - article - A Secular Wonder - Paolo Costa - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke - to - paper - A Secular Wonder - Paolo Costa - from book - The Joy of Secularism - 2011

      to - paper - A Secular Wonder - Paolo Costa - from book - The Joy of Secularism - 2011 - https://hyp.is/Lj9-Ss7DEe-_3TvpOSe_Ew/www.academia.edu/433395/A_Secular_Wonder

    17. Wonder isn't about solving a problem. Wonder is about remembering Sati, your Being, by putting you deeply in touch

      for - quote / comparison - wonder and curiosity - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

      quote / comparison - wonder and curiosity - Wonder isn't about problem solving - it is about remembering, by putting you deeply in touch with religio

    18. the point of wonder is, if curiosity gets you to focus in on specific features of the world, specific objects, wonder tries to get you to participate in the gestalt, the whole

      for -comparison - wonder and curiosity - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

      comparison - wonder and curiosity - curiosity drives you to focus and aspectualize one specific aspect of reality - wonder drives you to participate in the entire gestalt

    19. Religio is… I'm using it in a spiritual sense, [in] the sense of a pre-egoic, ultimately a post-egoic, binding that simultaneously grounds the self and its world.

      for - definition - religio - John Vervaeke - means to bind together, to connect. Here it is used in the sense of binding that simultanously grounds the self and its world - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

    20. Relevance Realization is Pre-Egoic. By the time you have ‘you’ in a ‘commonsensically’, obviated world of meaningful objects and situations, Relevance Realization has already done a tremendous, tremendous amount of work.

      for - quote - Relevance realization is pre-egoic - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

      quote - Relevance realization is pre-egoic - John Vervaeke - (see below) - Relevance Realization is Pre-Egoic. - By the time you have ‘you’ in a ‘commonsensically’, obviated world of meaningful objects and situations, - Relevance Realization has already done a tremendous, tremendous amount of work.

    21. Being able to pay attention to your mother and pick up on how she's communicating with you and make inferences from that so that you start to categorize the world and figure out that this is a bottle presupposes this (RR). And that points to something else: this is Pre-Experiential.

      for - relevance realization is pre-experiential - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

    22. it's deeper than your ego, it’s deeper than your judgements of truth, goodness and beauty. It's deeper than your propositional thinking. It's deeper than your conceptualisation. The way that can be spoken of is not the way!

      for - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

      question Relevance Realization - Depth? - How deep is it? - It's deeper than: - ego - your judgments of truth - goodness and beauty - your propositional thinking - your conceptualization - The way that can be spoken is not the way

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  2. Nov 2024
    1. a change towards climate-friendly behavior by citizens can reduce greenhouse gas (GHG) emissions substantially: up to one-third of the total EU mitigation target pledged

      for - stats - climate change - emissions reductions from behavioral change - 33% reduction in EU

  3. Oct 2024
  4. Jul 2024
    1. Olivetti Lettera 31 (Another name for the Dora -- or is it the opposite?) olivetti Dora (the actual base model if I'm not mistaken, with a bunch of rebrands worldwide) ETON (naturally this belongs on this list, I've even seen 2 others for sale online since) Underwood 315 (rebrand) Montgomery Ward Escort 33 (rebrand) Olivetti Underwood 310 (pretty sure this is a rebrand too, or at least very closely related) Olivetti Index (this is the closest thing I've found to my ETON branded one. It s PRACTICALLY the same in every regard - seen two online for sale) Montgomery ward escort 44 (also a rebrand of the DORA?!) Mercedes Super T (rebrand as well, seen one for sale) Montomery Ward Escort 77 (pretty close to being the same model again again... But not quite?) Neckermann BRILLANT Special T (DEFINITELY a rebrand. The manual is a dead give-away among other things) JUPITER (A typewriter 100% identical to the IDEX or ETON, but rebranded again again) Underwood 314 (no idea on this one. I gave up at this point)
    1. The Minimal Complete Typewriter Collection by [[Joe Van Cleave]]

      Joe Van Cleave's personal six categories in a (his) typewriter collection: - Standard manual - medium-sized portable (largest segment in the collector's space) - lightweight portable or ultra-portable - typebar electric - IBM Selectric - Electronic typewriter (thermal typewriter), portable, quiet, battery operation.

      Joe's minimal collection based on what he's got in his collection currently and the condition that they're in: - Royal KMM (his only standard) - Hermes 3000 (boxy middle era) - Olympia Splendid 33 (he's also got a Royal Mercury & Groma Kalibri) - Olympia Reporter - Selectric I (the only one he's got) cloth, ribbon cartridge system, no lift-off correction - Canon Typestar 220

      Some of Joe's most important criteria in a typewriter: he prefers an elite face, 1 1/2 spacing, and bichrome setting.

      At the time of this recording Joe had 30 typewriters.

  5. Mar 2021
    1. Results for individual PALB2 variants were normalized relative to WT-PALB2 and the p.Tyr551ter (p.Y551X) truncating variant on a 1:5 scale with the fold change in GFP-positive cells for WT set at 5.0 and fold change GFP-positive cells for p.Y551X set at 1.0. The p.L24S (c.71T>C), p.L35P (c.104T>C), p.I944N (c.2831T>A), and p.L1070P (c.3209T>C) variants and all protein-truncating frame-shift and deletion variants tested were deficient in HDR activity, with normalized fold change <2.0 (approximately 40% activity) (Fig. 1a).

      AssayResult: 5.8

      AssayResultAssertion: Normal

      StandardErrorMean: 0.1

    2. A total of 84 PALB2 patient-derived missense variants reported in ClinVar, COSMIC, and the PALB2 LOVD database were selected

      HGVS: NM_024675.3:c.26T>A p.(Leu9His)

    1. SUPPLEMENTARY DATA

      AssayResult: 108.6

      AssayResultAssertion: Not reported

      PValue: > 0.9999

      Comment: Exact values reported in Table S3.

    2. To this end, 44 missense variants found in breast cancer patients were identified in the ClinVar database (https://www.ncbi.nlm.nih.gov/clinvar) and/or selected by literature curation based on their frequency of description or amino acid substitution position in the protein (Supplemental Table S1).

      HGVS: NM_024675.3:c.3428T>C p.(Leu1143Pro)

    1. Source Data

      AssayResult: 24.31

      AssayResultAssertion: Abnormal

      ReplicateCount: 2

      StandardErrorMean: 5.23

      Comment: Exact values reported in “Source Data” file.

    2. Source Data

      AssayResult: 30.27

      AssayResultAssertion: Abnormal

      ReplicateCount: 2

      StandardDeviation: 1.04

      StandardErrorMean: 0.74

      Comment: Exact values reported in “Source Data” file.

    3. We, therefore, analyzed the effect of 48 PALB2 VUS (Fig. 2a, blue) and one synthetic missense variant (p.A1025R) (Fig. 2a, purple)29 on PALB2 function in HR.

      HGVS: NM_024675.3:c.2840T>C p.(L947S)

    1. Most Suspected Brugada Syndrome Variants Had (Partial) Loss of Function

      AssayResult: 1.1

      AssayResultAssertion: Abnormal

      ReplicateCount: 27

      StandardErrorMean: 0.8

      Comment: This variant had loss of function of peak current (<10% of wildtype), therefore it was considered abnormal (in vitro features consistent with Brugada Syndrome Type 1). (Personal communication: A. Glazer)

    2. we selected 73 previously unstudied variants: 63 suspected Brugada syndrome variants and 10 suspected benign variants

      HGVS: NM_198056.2:c.2783T>C p.(Leu928Pro)

  6. Feb 2021
    1. Supplemental material

      AssayResult: 105

      AssayResultAssertion: Normal

      Comment: See Table S2 for details

    2. Supplemental material

      AssayResult: 5

      AssayResultAssertion: Abnormal

      Comment: See Table S2 for details

    3. We analysed a total of 82 blood samples derived from 77 individuals (online supplemental table 3). These 77 individuals corresponded either to new index cases suspected to harbour a pathogenic TP53 variant or to relatives of index cases harbouring TP53 variants.

      HGVS: NM_000546.5:c.685T>C p.(Cys229Arg)

  7. Sep 2018
    1. In order to protect local interests, and to prevent sectional jealousies, it was found requisite that the three great divisions into which British North America is separated, should be represented in the Upper House on the principle of equality. There are three great sections, having different interests, in this proposed Confederation.
    2. To the Upper House is to be confided the protection of sectional interests ; therefore is it that the three great divisions are there equally represented, for the purpose of defending such interests against the combinations of majorities in the Assembly.
    1. But the very essence of our compact is that the union shall be federal and not legislative. Our Lower Canada friends have agreed to give us representation by population in the Lower House, on the express condition that they shall have equality in the Upper House. On no other condition could we have advanced a step ; and, for my part, I am quite willing they should have it. In maintaining the existing sectional boundaries and handing over the control of local matters to local bodies, we recognize, to a certain extent, a diversity of interests ; and it was quite natural that the protection for those interests, by equality in the Upper Chamber, should be demanded by the less numerous provinces.
    1. It is quite right that the General Government should have such powers; but the very fact of our having to make a reservation of this kind, is an unpleasant recognition of the fact, in itself the reverse of encouraging, of the all darkening neighborhood of the United States.

      §.33 of the Constitution Act, 1867.

  8. Mar 2018
    1. It would not become them to object to the nominative plan, because the members for the Upper House would be nominated by the Crown on the recommendation of the General Government. He might say it here, because it was said by everybody outside, that in the event of any thing like injustice being attempted towards the British population of Lower Canada by their French Canadian fellow-subjects, —they would moat unquestionably look for remedy and redress at the hands of the General Government, who would hare the power of causing their interests to be represented in the Upper House of the General Legislature.

      §§.24 and 33 of the Constitution Act, 1867.

  9. Apr 2017
    1. so that the blessed news had to circulate from individual to individual

      On plantations slaves were often not allowed to practice religion or anything of their choice because they were not looked at a people. They had to find other ways to do this, so instead of having things like churches or massing they usually told stories that passed down from person to person