22 Matching Annotations
  1. Nov 2025
    1. new definition, which defines a city as a contiguous geographic area with at least 50,000 inhabitants at an average population density of 1,500 people per square kilometer

      for - definition - city - a geographic area with - at least 50,000 inhabitants - an average population density of 1,500 people/square kilometer - stats - 25% of people live in towns - 48 % of people live in cities - 25% of people live in villages - towns and cities

      • according to this new definition, which standardizes the definition of city that has, hitherto been quite varied, 48% of humanity lives in cities (2015)
  2. Jan 2025
  3. Dec 2024
  4. Feb 2024
  5. Aug 2023
  6. Mar 2021
    1. Results for individual PALB2 variants were normalized relative to WT-PALB2 and the p.Tyr551ter (p.Y551X) truncating variant on a 1:5 scale with the fold change in GFP-positive cells for WT set at 5.0 and fold change GFP-positive cells for p.Y551X set at 1.0. The p.L24S (c.71T>C), p.L35P (c.104T>C), p.I944N (c.2831T>A), and p.L1070P (c.3209T>C) variants and all protein-truncating frame-shift and deletion variants tested were deficient in HDR activity, with normalized fold change <2.0 (approximately 40% activity) (Fig. 1a).

      AssayResult: 6.4

      AssayResultAssertion: Normal

      StandardErrorMean: 0.45

    1. Most Suspected Brugada Syndrome Variants Had (Partial) Loss of Function

      AssayResult: 39

      AssayResultAssertion: Abnormal

      ReplicateCount: 16

      StandardErrorMean: 6.4

      Comment: This variant had partial loss of function of peak current (10-50% of wildtype), therefore it was considered abnormal (in vitro features consistent with Brugada Syndrome Type 1). (Personal communication: A. Glazer)

  7. Feb 2021
  8. Feb 2019
  9. Jun 2018