5 Matching Annotations
  1. Last 7 days
    1. The mind is a processor, not a hard drive.

      The Neuroscience: Your brain’s working memory—housed primarily in the prefrontal cortex—is designed to process incoming data, not store it indefinitely. It has a severely limited capacity. When you attempt to hold daily spiritual and emotional coordinates purely in your working memory, you create massive cognitive friction. This forces the brain into "survival mode," where it drops nuanced data (like profound lessons or subtle lies) to conserve energy. By writing the data down, you mechanically offload this burden. Externalisation transfers the information from the volatile "processor" to a permanent physical ledger, freeing the prefrontal cortex to remain regulated and present.

  2. Oct 2023
  3. Jan 2016
    1. it has been found that cocaine-seeking behavior is associated with increased activity in the projection from the prefrontal cortex to the nucleus accumbens, specifically in the glutamatergic projection from the prelimbic cortex (PL) to the core subcompartment of the nucleus accumbens (NAcore) (McFarland et al., 2003; Rebec & Sun, 2005).
    1. not only does inactivation of either the NAcore or prelimbic cortex prevent cue-, stress-, or cocaine-induced reinstatement of cocaine seeking (McFarland and Kalivas, 2001; McLaughlin and See, 2003; Di Ciano and Everitt, 2004; Fuchs et al., 2004; Di Ciano et al., 2008), but both cocaine- and stress-induced cocaine seeking are associated with a remarkable overflow of synaptic glutamate into the NAcore from prelimbic afferents (McFarland et al., 2003, 2004; Xi et al., 2006; Miguéns et al., 2008).
  4. Oct 2015