Nature Medicine "A minimally invasive dried blood spot biomarker test for the detection of Alzheimer's disease pathology" Jan 5, 2026. The abstract does not mention the 10-20yr early warning finding.
This is the actual link https://www.nature.com/articles/s41591-025-04080-0
Blood biomarkers have emerged as accurate tools for detecting Alzheimer's disease (AD) pathology, offering a minimally invasive alternative to traditional diagnostic methods such as imaging and cerebrospinal fluid (CSF) analysis.
States as given that blood tests are accurate tools for detecting Alzheimer's.
Yet, further refinement of collection and analytical protocols is needed to fully translate this approach to be viable and useful as a clinical tool.
However, not yet at the stage this can be used as a clinical tool for diagnostics.
indings underscore the potential of dried blood collection and capillary blood as a minimally invasive, scalable approach for AD biomarker testing in research settings
For research dried capillary blood collection is useful and minimally invasive.
The study also explored unsupervised blood collection, finding high concordance between supervised and self-collected samples.
The study looked at self-administered blood collection too.
DROP-AD project investigates the potential of dried plasma spot (DPS) and dried blood spot (DBS) analysis, derived from capillary blood, for detecting AD biomarkers,
The project this paper is a result of looks at the utility of dried blood spots and plasma spots for analysis.
Yet, the logistics surrounding venipuncture for blood collection, although considerably simpler than the acquisition of imaging and CSF, require precise processing and storage specific to AD biomarkers that are still guided by medical personnel. Consequently, limitations in their widescale use in research and broader clinical implementation exist. T
Problem statement is that while blood tests are an easy method, there are limits on widescale use, due to some specific cares needing to be taken in the process.
A home bloodtest has been developed at Göteborg Uni with international partners, to check for brain changes 10-20yrs before any dementia symptoms become apparent. This chimes w. other research I saw wrt changes in banking transactions 10yr before symptoms, and early changes in the spatial brain. Can I find publications? The .se researcher is Henrik Zetterberg
in 2007 um we saw the publication of three empirical papers that really kind of galvanized this close relationship between past and future thinking
for - adjacency - memory - imagination critical papers - 2007 - some types of Alzheimer patient cannot imagine the future
Nice review of network-based studies on neurodegenerative diseases. It shows the main findings of studies using network-based approaches. However, it does not generate a particular perspective on the main problems to solve, future directions (beyond more network-based studies and experimental validation), methodological issues or competing perspectives, etc
Positive study
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