4 Matching Annotations
  1. Mar 2021
    1. The expectation is that IBD = 1 for duplicates or monozygotic twins, IBD = 0.5 for first-degree relatives, IBD = 0.25 for second-degree relatives and IBD = 0.125 for third-degree relatives. Due to genotyping error, LD and population structure there is often some variation around these theoretical values and it is typical to remove one individual from each pair with an IBD > 0.1875, which is halfway between the expected IBD for third- and second-degree relatives. For these same reasons an IBD > 0.98 identifies duplicates.

      IBD过滤标准.IBD即plink结果中的PI_HAT。

    2. The method works best when only independent SNPs are included in the analysis. To achieve this, regions of extended linkage disequilibrium (LD) (such as the HLA) are entirely removed from the dataset8 and remaining regions are typically pruned so that no pair of SNPs within a given window (say, 50kb) is correlated (typically taken as r2>0.2)

      LD过滤,但实际发现过滤后位点很少,关联效应很弱

  2. Mar 2015
    1. θ dμ ≥ p 16 π | Σ |

      Qual a relação dessa desigualdade com a dita desigualdade de Penrose Riemanniana provada por Huisken-Ilmanen e Bray?

    2. GIBBONS-PENROSE INEQUALITY

      Qual a relação dessa desigualdade com a dita desigualdade de Penrose Riemanniana provada por Huisken-Ilmanen e Bray?