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  1. Apr 2026
    1. Urgent treatment for neoplasm consists of (1) cautious use of intravenous diuretics and (2) mediastinal irradiation, starting within 24 hours, with a treatment plan designed to give a high daily dose of radiation but a short total course of therapy to rapidly shrink the local tumor. Intensive radiation therapy combined with chemotherapy will palliate the process in up to 90% of patients. In patients with a subacute presentation, radiation therapy alone usually suffices. Chemotherapy is added if lymphoma or small-cell carcinoma is diagnosed

      endovascular stenting emerging as first-line therapy for rapid symptom relief, while definitive treatment targets the underlying cause

      Glucocorticoids (dexamethasone 4 mg every 6 hours) are commonly prescribed but lack robust supporting data; they may be more beneficial in lymphoma or thymoma and as prophylaxis against radiation-induced edema. [2-4] Importantly, SVC syndrome is no longer considered a medical emergency except in rare cases with life-threatening cerebral edema, laryngeal edema, or altered mental status. When thrombosis is present, catheter-directed thrombolysis or aspiration thrombectomy should be performed within 2-5 days of symptom onset before thrombus organization occurs. [3] The role of long-term anticoagulation after stenting remains unclear, though it is standard when significant thrombosis is present The American College of Chest Physicians recommends obtaining histologic diagnosis before treatment in suspected lung cancer cases, as stenting does not interfere with tissue diagnosis. [2] For small cell lung cancer (SCLC), chemotherapy alone is recommended as first-line treatment given rapid response rates. [2] For non-small cell lung cancer (NSCLC), radiation therapy and/or stent insertion are recommended, with response rates of 59% for chemotherapy and 63% for radiation therapy. [2] Patients with chemotherapy- or radiation-refractory disease should receive vascular stents For device-related thrombosis (catheters, pacemakers), catheter removal should be considered in conjunction with anticoagulation. [4] Endovascular therapy is first-line for device-related obstruction, while surgical bypass may be preferred for mediastinal fibrosis. [7] Both approaches show good mid-term patency, though secondary interventions are common (approximately 27-28%

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  2. Jul 2024
    1. until relatively modern times uh until really the beginning of the enlightenment of the industrial revolution people thought of progress in a moral sense 00:02:17 or a spiritual sense

      for - definition - progress

      definition - progress - before enlightenment, progress was defined in a moral and spiritual sense - after the enlightenment and industrial revolution, it was defined in a material sense

  3. Feb 2023
    1. I find it very tiring haha. As I said in another comment, processing a single chapter can take me a full day or two. However, I keep reminding myself that I would rather spend a day processing a chapter well, and have literature notes to serve me a lifetime (potentially, at least), rather than reading a chapter in two hours and not remember a single thing the next day. When I REALLY need a reminder of this, I just look at my "Backlog" folder which contains old "notes" that are now pretty much useless: I didn't use a reference manager consistently during my first two years of PhD so there are a lot of citations which are unreliable; I didn't really summarise texts, I only read them and highlighted; I didn't use the cloud for a long time, so I lost a lot of notes; and I didn't have Obsidian, so a lot of my notes are just contained within the context of the place I read them, rather than being connected. Seeing three years worth of useless materials, and knowing that I read a couple hundred of articles/chapters but I have nothing to show for it, that makes me more patient when writing my literature notes now. However I also find it very exciting that I can future-proof some of my notes. I feel like I'm working for my future self.

      A partial answer to note taking why.

  4. Nov 2020