373 Matching Annotations
  1. Feb 2025

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  2. Nov 2024
    1. Disease: N/A, variant present in F12 gene

      Patient: 36 yo, Female, Saudi descent

      Variant:F12 NC_000005.9:g.176,830,269 G>A; p.Gly506Asp Homozygous mutation, exon 12 Located in peptidase S1 domain of F12

      Family:

      Consanguineous family history (parents first-degree cousins)

      No family history of bleeding or thrombosis

      Phenotypes:

      Significantly high activated partial thromboplastin time

      No history of bleeding during deliveries or tooth extractions

      No history of thrombosis or skin manifestations

      On no medications, physical examination unremarkable

      Factor assays and VWF tests within normal ranges except Factor XII (Severely deficient)

      variant is proposed to be deleterious but there is insufficient evidence to support this claim.

  3. Jul 2020
  4. May 2016
    1. Well, the obvious topic is "fan fiction," but as you can tell just from scanning the subject index, we've branched out a bit - columns on fannish politics, columns that focus more on the show itself, columns on writing, etc.  Bottom line: is it going to be of interest to fanfic writers and readers?

      This is bad ass.

    1. Fan fiction alludes to universes which resemble those of the source text but which are also transformed in accordance with the writer's creative impulses and with reference to generic conventions and interpretive conventions of the fan community.

      ** Best description.

    2. This transportation may be so complete that they respond emotionally to the events portrayed as if they were situations involving real-life people rather than characters--that they become, in other words, emotionally immersed

      Couldn't this be said about anything and anyone?

    3. Fans approach fan fiction with highly detailed schemata in mind: of the characters, for example. If writers of fan fiction simply described the primary text, readers would no longer have the challenge of imagining something new and such texts would be too boring to be immersive. In effect, fans tend to value fics the most when they both adhere to canon and diverge from it

      * Important.

    4. Abigail Derecho argues that fan writers add artifacts to an archive surrounding the source text and "all texts related to it" (63-65) and Juli J. Parrish insists that fan writers "reimagine the preserve itself" (67-68).

      "Hypotext" and "hypertext"

  5. Oct 2015
  6. Sep 2015
    1. 矛盾

      矛盾 máodùn ①名 矛和盾。《韩非子难一》中说:楚国有一个卖矛和盾的人夸口说,我的盾是最坚硬的,什么东西也戳不破;又说,我的矛是最锐利的,什么东西都能刺进去。有人问,用你的矛刺你的盾怎么样?那个人不能回答。后用“矛盾”比喻言论或行为自相冲突或两种事物彼此抵触,互不相容的现象。 这篇文章前后有很多矛盾。 ②名 指隔阂或嫌隙。 他们之间的矛盾由来已久。 ③名 哲学上指客观事物和人类思维中普遍存在着的对立的两方面之间互相排斥又互相依存的关系。 ④名 形式逻辑中指两个概念互相排斥或两个判断不能同真也不能同假的相互关系。 ⑤形 形容人或事物互相抵触或排斥。 这两项规则之间很矛盾 | 自相矛盾

    2. 作为

      作为 zuòwéi ①名 所作所为;行为。 自己的作为自己负责。 ②名 特指好的作为;成就。 有所作为 | 大有作为 ③动 指积极地履行自己的职责。 ④动 当作。 把他作为朋友看待。 ⑤介 引进人的某种身份或事物的某种性质,表示“就……来说”(多用在句首)。 作为公务员,一定要守法。

    3. 履行

      faire son devoir 履行 lǚxíng 动 按约定或职责去做。 履行公约 | 履行职责 用法说明 跟“实行” “执行”不同。“履行”指实践所承诺的义务,对象多为带约束性的条约、合同、诺言等;“实行”指用行动来实现已有的设想,对象多为预定的政策、方针、计划、方案等;“执行”指实施上级规定的任务,对象多为带强制性的命令、指示、判决、法令等。