64 Matching Annotations
  1. Oct 2019
    1. Amygdala volumes were significantly reduced in men with 47,XXY, compared to control men, while the decrease in women with 47,XXX was not as pronounced

      volume decreases with diagnosis (control -> 47,XXY) gender: female structure: amygdala

      volume decreases with diagnosis (control -> 47,XXY) gender: male structure: amygdala

    2. Hippocampus volumes were preserved in both groups, compared to same-gender controls.

      volume NSC with diagnosis (control -> 47,XXY) gender: male structure: hippocampus

      volume NSC with diagnosis (control -> 47,XXY) gender: female structure: hippocampus

    1. Compared with HCs, the male adolescent offenders showed significantly reduced GMV in five cortical and subcortical brain regions, including the olfactory cortex, amygdala, middle temporal gyrus and inferior parietal lobe in the left hemisphere, as well as the right superior temporal gyrus

      volume decreases with diagnosis (control -> violent offender) structure: olfactory cortex; amygdala; middle temporal gyrus; superior temporal gyrus hemisphere: left

      volume decreases with diagnosis (control -> violent offender) structure: olfactory cortex; amygdala; middle temporal gyrus; superior temporal gyrus hemisphere: left structure: inferior parietal lobe

  2. Sep 2019
    1. We found decreased gray-matter volume in posterior brain regions, including the posterior hippocampus and cuneus, as well as increased gray-matter volume in frontal brain regions, including the medial prefrontal cortex, superior and inferior frontal gyri, and middle temporal gyrus in individuals with ASD

      volume decreases with diagnosis (control -> ASD) structure: posterior cuneus

      volume increases with diagnosis (control -> ASD) structure: medial prefrontal cortex

      volume decreases with diagnosis (control -> ASD) structure: posterior hippocampus

      volume increases with diagnosis (control -> ASD) structure: middle temporal gyrus

      volume increases with diagnosis (control -> ASD) structure: inferior frontal gyrus

      volume increases with diagnosis (control -> ASD) structure: superior frontal gyrus

    1. There was a weak but significant inverse correlation between age and normalized hippocampal, but not temporal lobe or whole-brain, volume

      normalized volume decreases with age structure: hippocampus diagnosis: healthy

      normalized volume NSC with age structure: temporal lobe diagnosis: healthy

      normalized volume NSC with age structure: whole brain diagnosis: healthy

    2. we found no significant side-to-side differences in the sizes of temporal lobes or hippocampi

      volume NSC with ['hemisphere', 'left', 'right'] structure: temporal lobe

      volume NSC with ['hemisphere', 'left', 'right'] structure: hippocampus

  3. May 2019
    1. Python Hypothesis package

      This annotation is for the python-hypothesis test suite.

  4. Apr 2019
    1. ASD boys had a larger left MTG/STG GM volume relative to healthy controls and at a more lenient threshold relative to ADHD boys.

      volume increases with diagnosis (control; ADHD -> ASD) hemisphere: left structure: MTG/STG

    2. ADHD boys having a significantly smaller right posterior cerebellar GM volume compared to healthy controls and ASD boys, who did not differ from each other

      volume decreases with diagnosis (control; ASD -> ADHD) structure: posterior cerebellar GM hemisphere: right

      volume NSC with diagnosis (control -> ASD) structure: posterior cerebellar GM hemisphere: right

    1. the left caudate nucleus volume was negatively correlated with ASD ratings (t = 2.83; P = 0.005).

      volume decreases with ASD rating structure: caudate nucleus hemisphere: left

    1. age-related volume loss was significantly greater in men than women in whole brain and frontal and temporal lobes, whereas it was greater in women than men in hippocampus and parietal lobes

      volume decreases with age gender: male; female structure: whole brain; frontal lobe; temporal lobe; hippocampus; parietal lobe

    1. Anterior hippocampal volume did not differ between patients and controls.

      volume shows no change with diagnosis (control -> MDD) structure: anterior hippocampus

    2. showed smaller total and posterior hippocampal volume relative to controls.

      volume decreases with diagnosis (control -> MDD) structure: total hippocampus; posterior hippocampus

    1. Compared with the sMCI group, the volume of the left thalamus, bilateral hippocampus, corpus callosum posterior and corpus callosum central was smaller in pMCI subjects

      volume decreases with group (sMCI -> pMCI) structure: corpus callosum posterior; corpus callosum central

      volume decreases with group (sMCI -> pMCI) structure: thalamus; hippocampus hemisphere: left

      volume decreases with group (sMCI -> pMCI) structure: hippocampus hemisphere: right

    1. A positive association between the Eyes Test score and gray matter volume of this region was evident in the control group, but not in the ASD group

      volume increases with eyes test score structure: TPJ gray matter diagnosis: control hemisphere: left

      volume shows no change with eyes test score structure: TPJ gray matter diagnosis: ASD hemisphere: left

    2. the Eyes Test scores were lower in the ASD group than in the control group

      eyes test score decreased with diagnosis (control -> ASD)

    1. regional gray matter volume was lower in the ASD than in the control group in several brain regions, including the right inferior occipital gyrus, left fusiform gyrus, right middle temporal gyrus, bilateral amygdala, right inferior frontal gyrus, right orbitofrontal cortex, and left dorsomedial prefrontal cortex

      volume decreases with diagnosis (control -> ASD) structure: fusiform gyrus; dorsomedial prefrontal cortex; amygdala hemisphere: left

      volume decreases with diagnosis (control -> ASD) structure: inferior occipital gyrus; middle temporal gyrus; amygdala; inferior frontal gyrus; orbitofrontal cortex hemisphere: right

    1. Hippocampal volume was positively related to age of trauma onset and level of psychopathology

      volume increases with age of trauma structure: hippocampus

      volume increases with level of psycopathology structure: hippocampus diagnosis: PTSD

    2. Segmented hippocampal white-matter volume was greater in PTSD subjects but not gray-matter volume

      volume increases with diagnosis (control -> PTSD) structure: hippocampal white matter

      volume NSC with diagnosis (control -> PTSD) structure: hippocampal gray matter

    3. we observed a significantly larger hippocampus controlling for cerebral volume in PTSD subjects compared with control subjects

      volume controlled for cerebral volume increases with diagnosis (control -> PTSD) structure: hippocampus

    1. We did not observe differences in cortical thickness in professional rugby league players compared to controls

      cortical thickness NSC group (control -> rugby player)

    2. Within the players group, there were significant associations between greater alcohol use and smaller bilateral hippocampi and left amygdala volumes

      volume decreases with alcohol use structure: hippocampus hemisphere: left; right

      volume decreases with alcohol use structure: amygdala hemisphere: left

    3. Professional players had smaller whole brain (p = .003), bilateral hippocampi (ps = .03), and left amygdala volumes (p = .01) compared to healthy controls

      volume decreases with group (control -> rugby player) structure: whole brain

      volume decreases with group (control -> rugby player) structure: hippocampus hemisphere: left; right

      volume decreases with group (control -> rugby player) structure: amygdala hemisphere: left

    4. There were no differences in cortical thickness between the groups

      cortical thickness NSC group (rugby player -> control)

    1. Fibroscan value was significantly correlated with PBC-40 (Spearman's rho = 0.499; p = 0.041) and disease duration (Spearman's rho = 0.568; p = 0.017).

      fibroscan value increases with diagnosis (control -> PBC-40); disease duration

    2. PBC patients exhibited significantly reduced hippocampal volume (p = 0.023) and increased susceptibility (p = 0.048).

      volume decreases with diagnosis (control -> PBC) structure: hippocampus

      susceptibility increases with diagnosis (control -> PBC)

    1. Youths with ADHD had smaller caudate and putamen volumes compared to both BP groups and they had moderately smaller total amygdala volumes compared to the other three groups

      volume decreases with diagnosis (bp; bp+adhd -> adhd) structure: caudate; putamen

      volume decreases with diagnosis (bp; bp+adhd; hc -> adhd) structure: amygdala

    1. However, women had larger orbital frontal cortices than men

      volume increases with gender (male -> female) structure: orbital frontal cortex

    2. After correcting for cranial volume, men and women had identical volumes of amygdala and hippocampus, as well as dorsal prefrontal cortex.

      volume corrected for cranial volume NSC gender structure: amygdala; hippocampus; dorsal prefrontal cortex

    1. There were no significant differential sex effects in subcortical gray matter regions or cerebrospinal fluid.

      volume NSC gender structure: subcortical gray matter; cerebrospinal fluid

    1. The AQ scores correlated negatively with average left STS grey matter volume in women with anorexia nervosa.

      volume decreases with AQ score gender: female diagnosis: anorexia nervosa hemisphere: left structure: STS grey matter

    2. Women with anorexia nervosa (n = 25) had higher AQ scores and lower bilateral superior temporal sulcus (STS) grey matter volumes than the control group (n = 25).

      AQ score increases with diagnosis (control -> anorexia nervosa) Gender: female

      volume decreases with diagnosis (control -> anorexia nervosa) gender: female constant: lower bilateral STS gray matter

    1. normalizing measurements for the whole brain eliminated intersex temporal lobe and hippocampal differences

      DV: volume normalized to whole brain IV: gender (male -> female) Direction: NSC Constant: structure (temporal lobe)

      DV: volume normalized to whole brain IV: gender (male -> female) Direction: NSC Constant: structure (hippocampus) Constant: hemisphere (left)

    2. whole-brain, temporal lobe, and left hippocampal volumes were significantly smaller in women

      DV: volume IV: gender (male->female) Direction: decrease Constant: structure (whole-brain; temporal lobe)

      DV: volume IV: gender (male->female) Direction: decrease Constant: structure (hippocampus) Constant: hemisphere (left)

  5. Feb 2019
    1. a reduced volume of GM in 11 clusters in the boys with LFASD (i.e., the left inferior frontal gyrus, orbital part; right superior temporal gyrus, superior frontal gyrus, dorsolateral; precuneus and postcentral; bilateral rectus and middle temporal gyrus)

      dep: GM dir: reduces ind: diagnosis (Control -> LFASD) constant: structure: right superior temporal gyrus ; superior frontal gyrus, dorsolateral constant: gender: male

  6. Feb 2018
  7. Nov 2017
  8. Jan 2017
    1. Headline: ReproNim has a new home on NITRC Body: ReproNim's new page on NITRC has pointers to news, announcements, and code. Visit today!

  9. Sep 2016
  10. Aug 2016
  11. Mar 2016
    1. 19 with BPD I with psychosis (mean age = 11.6 ± 2.6 years),

      ID: BPwPsy Diagnosis: Bipolar Disorder I with Psychosis NSubjects: 19 AgeMean: 11.6 years AgeSD: 2.6 years

    2. structural acquisitions included a conventional T1-weighted sagittal scout series, a proton density/T2-weighted interleaved double-echo axial series, and a three-dimensional inversion recovery-prepped spoiled grass coronal series

      ID: Scout Type: Scout AcquisitionInstrument: McLeanScanner

      ID: T2 Type: PD/T2 AcquisitionInstrument: McLeanScanner

      ID: Anatomical Type: SPGR AcquisitionInstrument: McLeanScanner

    3. The regions of interest (ROIs) in this study consisted of the amygdala and hippocampus with all other subcortical structures included in an exploratory way

      ID: BPwPsyStructuralVolumes Measure: Brain structure volumes AnalysisWorkflow: VolumetricWorkflow Data: BPwPsyStructuralData

      ID: BPwoPsyStructuralVolumes Measure: Brain structure volumes AnalysisWorkflow: VolumetricWorkflow Data: BPwoPsyStructuralData

      ID: HCStructuralVolumes Measure: Brain structure volumes AnalysisWorkflow: VolumetricWorkflow Data: HCStructuralData

      ID: SZStructuralVolumes Measure: Brain structure volumes AnalysisWorkflow: VolumetricWorkflow Data: SZStructuralData

    4. Significant diagnostic differences were seen in the left and right cerebral volumes in interaction with sex (right: F3,93 = 2.9, P = .04; left: F3,93 = 3.1, P = .04).

      ID: LCerebralVolume ModelApplication: RLSubcBrainVolumes Value: Left Cerebral Volume Variable: Diagnosis+Sex F: 2.9 P: 0.04 Interpretation: Significant differences

      ID: RCerebralVolume ModelApplication: RLSubcBrainVolumes Value: Right Cerebral Volume Variable: Diagnosis+Sex F: 3.1 P: 0.04 Interpretation: Significant differences

    5. Differences in right and left subcortical brain volumes

      ID: RLSubcBrainVolumes Model: Model1 Observation: BPwPsyStructuralVolumes Observation: BPwoPsyStructuralVolumes Observation: HCStructuralVolumes Observation: SZStructuralVolumes

    6. In brief, structural scans were transferred to the Center for Morphometric Analysis-Charlestown Massachusetts General Hospital and coded and catalogued for blind analysis. Imaging analysis was done by 2 raters on Sun Microsystems, Inc (Mountainview, CA) workstations using Cardviews software.44 The datasets were positionally normalized to overcome variations in head position and then segmented into gray, white, and cerebrospinal fluid (CSF) tissue classes. The segmentation method uses a semiautomated intensity contour algorithm for external border definition and signal intensity histogram distributions for delineation of gray-white borders. Total cerebral volume (TCV) was defined as all tissue in the cerebrum, including CSF, and excluded cerebellum and brain stem

      ID: VolumetricWorkflow Method: CMA segmentation MethodURL: http://www.ncbi.nlm.nih.gov/pubmed/8921207 Software: Cardviews

    7. three-dimensional inversion recovery-prepped spoiled grass coronal series

      ID: BPwPsyStructuralData SubjectGroup: BPwPsy Acquisition: Anatomical DOI: 10.18116/C6159Z

      ID: BPwoPsyStructuralData SubjectGroup: BPwoPsy Acquisition: Anatomical DOI: 10.18116/C6159Z

      ID: HCStructuralData SubjectGroup: HC Acquisition: Anatomical DOI: 10.18116/C6159Z

      ID: SZStructuralData SubjectGroup: SZ Acquisition: Anatomical DOI: 10.18116/C6159Z

    8. 29 HCs (mean age = 10.5 ± 2.9 years).

      ID: HC Diagnosis: Healthy control NSubjects: 29 AgeMean: 10.5 years AgeSD: 2.9 years

    9. 20 with SZ or schizoaffective disorder (mean age = 13.5 ± 2.9 years),

      ID: SZ Diagnosis: Schizoaffective disorder NSubjects: 20 AgeMean: 13.5 years AgeSD: 2.9 years

    10. 35 youths with BPD I without psychosis (mean age = 10.4 ± 3.0 years),

      ID: BPwoPsy Diagnosis: Bipolar Disorder I without Psychosis NSubjects: 35 AgeMean: 10.4 years AgeSD: 3.0 years

    11. 2-way (diagnosis, sex) univariate analyses covarying for TCV and age

      ID: Model1 Variable: Diagnosis Variable: Sex Variable: Diagnosis+Sex Variable: TCV Variable: Age

    12. McLean Hospital Brain Imaging Center on a 1.5 Tesla General Electric Signa Scanner

      ID: McLeanScanner Type: MR Location: McLean Hospital Field: 1.5T Manufacturer: GE Model: Signa

    13. All statistical tests were 2 sided with alpha = .05. JMP 7 for Mac (SAS Institute, Cary, NC) was used for statistical analysis

      +ID: RLSubcBrainVolumes Software: JMP for Mac