Commemorated as the Stalin Dam on October 10, 1932, the Dnepr River dam remains the largest electricity producer in Ukraine today.
Tell us more, both about the Dnepr River Dam and Hugh Cooper. Why did he choose to take on this project? What has changed about the dam in the past 100 years?
hese rehab facilities the these addiction treatment centers they they they CL 85% of them in the US are based on the disease model 85% and an almost overlapping 85% uses 12-step methods as their primary primary uh um uh intervention method well you know that's hard to actually figure out because medicine is this and 12 steps has very little to do with medicine it's kind of based on a religious orientation
> for - stats - addiction - rehab centers - 85% are based on disease model - and 85% use a religious oriented 12 step program
Most people in America today (85–90%) agree on most issues and topics (85–90%). The so-called polarization is the result of a media landscape that amplifies the voices of the 10–15% that keep constantly talking about the 10–15% of topics on which people are not on the same page.
for - stats - most people in America agree on 85 - 90% of issues - unpack why and how the 10 - 15% is made so divisive
Cells reconstituted with WT-PALB2 showed substantially less sensitivity to olaparib than cells expressing p.A1025R and p.I944N (Fig. 4a). Similar results were observed for cisplatin treatment, although the difference in sensitivity was less pronounced (Fig. 4b). p.L24S, p.L1070P, and p.L35P were also associated with greater sensitivity to olaparib (Fig. 4c) and cisplatin (Fig. 4d) than WT-PALB2.
AssayResult: 0.01 µM: 102; 0.1 µM: 65; 0.8 µM: 18; 1 µM: 10
AssayResultAssertion: Abnormal
Approximation: Exact cisplatin concentrations and assay result values not reported; values estimated from Figures 4b and 4d.
Cells reconstituted with WT-PALB2 showed substantially less sensitivity to olaparib than cells expressing p.A1025R and p.I944N (Fig. 4a). Similar results were observed for cisplatin treatment, although the difference in sensitivity was less pronounced (Fig. 4b). p.L24S, p.L1070P, and p.L35P were also associated with greater sensitivity to olaparib (Fig. 4c) and cisplatin (Fig. 4d) than WT-PALB2.
AssayResult: 0.01 µM: 70; 0.08 µM: 50; 0.8 µM: 40; 8 µM: 15
AssayResultAssertion: Abnormal
Approximation: Exact Olaparib concentrations and assay result values not reported; values estimated from Figures 4a and 4c.
WT-PALB2 was associated with robust formation of damage-induced RAD51 foci, whereas the four variants were associated with defective foci formation (Fig. 3d, e).
AssayResult: 3
AssayResultAssertion: Abnormal
Approximation: Exact assay result value not reported; value estimated from Figure 3e.
Results for individual PALB2 variants were normalized relative to WT-PALB2 and the p.Tyr551ter (p.Y551X) truncating variant on a 1:5 scale with the fold change in GFP-positive cells for WT set at 5.0 and fold change GFP-positive cells for p.Y551X set at 1.0. The p.L24S (c.71T>C), p.L35P (c.104T>C), p.I944N (c.2831T>A), and p.L1070P (c.3209T>C) variants and all protein-truncating frame-shift and deletion variants tested were deficient in HDR activity, with normalized fold change <2.0 (approximately 40% activity) (Fig. 1a).
AssayResult: 1.7
AssayResultAssertion: Abnormal
StandardErrorMean: 0.34
A total of 84 PALB2 patient-derived missense variants reported in ClinVar, COSMIC, and the PALB2 LOVD database were selected
HGVS: NM_024675.3:c.71T>C p.(Leu24Ser)
The trick is to work at 85% capacity rather than 100%. It can be surprisingly challenging to take your effort down a notch and keep it there — especially right now when so many livelihoods feel precarious. But going full-throttle all the time actually works against you. When your mind is relaxed, you’re able to produce better, more thoughtful results.
Rather than working 100% of the time most of the time, work 85%. This decreases stress and helps you last longer
Fri Dec 23 2016 17:34:59 GMT-0800 (Pacific Standard Time)