9 Matching Annotations
  1. Apr 2026
    1. Urgent treatment for neoplasm consists of (1) cautious use of intravenous diuretics and (2) mediastinal irradiation, starting within 24 hours, with a treatment plan designed to give a high daily dose of radiation but a short total course of therapy to rapidly shrink the local tumor. Intensive radiation therapy combined with chemotherapy will palliate the process in up to 90% of patients. In patients with a subacute presentation, radiation therapy alone usually suffices. Chemotherapy is added if lymphoma or small-cell carcinoma is diagnosed

      endovascular stenting emerging as first-line therapy for rapid symptom relief, while definitive treatment targets the underlying cause

      Glucocorticoids (dexamethasone 4 mg every 6 hours) are commonly prescribed but lack robust supporting data; they may be more beneficial in lymphoma or thymoma and as prophylaxis against radiation-induced edema. [2-4] Importantly, SVC syndrome is no longer considered a medical emergency except in rare cases with life-threatening cerebral edema, laryngeal edema, or altered mental status. When thrombosis is present, catheter-directed thrombolysis or aspiration thrombectomy should be performed within 2-5 days of symptom onset before thrombus organization occurs. [3] The role of long-term anticoagulation after stenting remains unclear, though it is standard when significant thrombosis is present The American College of Chest Physicians recommends obtaining histologic diagnosis before treatment in suspected lung cancer cases, as stenting does not interfere with tissue diagnosis. [2] For small cell lung cancer (SCLC), chemotherapy alone is recommended as first-line treatment given rapid response rates. [2] For non-small cell lung cancer (NSCLC), radiation therapy and/or stent insertion are recommended, with response rates of 59% for chemotherapy and 63% for radiation therapy. [2] Patients with chemotherapy- or radiation-refractory disease should receive vascular stents For device-related thrombosis (catheters, pacemakers), catheter removal should be considered in conjunction with anticoagulation. [4] Endovascular therapy is first-line for device-related obstruction, while surgical bypass may be preferred for mediastinal fibrosis. [7] Both approaches show good mid-term patency, though secondary interventions are common (approximately 27-28%

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  2. Mar 2024
  3. Jul 2023
  4. Nov 2021
    1. I find some of XDG's default dirs, especially ~/.local/share/whatever, to be very annoying. (Almost as annoying as having ~/snap polluting my home dir, but for a different reason.) I shouldn't have to type such long paths or navigate three folders deep in order to access my data files. I therefore make use of the XDG_DATA_HOME environment variable for XDG-style programs, so they will put my files somewhere convenient. However, I don't think Snap can honor that variable, because AppArmor rules require fixed paths. Given 1 & 2, I think ~/.snap/data is a sensible compromise, at least until the underlying components are flexible enough to let the user choose.
  5. Jun 2021
  6. May 2021
  7. Jan 2020
    1. The Web Annotation Data Model specification describes a structured model and format to enable annotations to be shared and reused across different hardware and software platforms.

      The publication of this web standard changed everything. I look forward to true testing of interoperable open annotation. The publication of the standard nearly three years ago was a game changer, but the game is still in progress. The future potential is unlimited!

  8. Nov 2019