13 Matching Annotations
  1. Last 7 days
    1. The worry most people have with this suggestion is that children are going to get discouraged if they fail. But that is not necessarily the case, and I think teachers, parents, and other adults have a great opportunity to help prevent this. If we demonstrate that needing to put down a book for awhile is not a failure, then we can help children become more willing to experiment and to try things which are currently just out of reach.

      This is the concept of growth mindset; and we need to teach that to our children in any way possible. It has been shown in studies that growth mindset has a positive causal influence on academic and financial success (I cannot state sources, but I know I've come across this)

      Note to self: Research this later.

  2. Aug 2023
  3. Jan 2020
    1. The substitution of l-T3 for l-T4 at equivalent doses (relative to the pituitary) reduced body weight and resulted in greater thyroid hormone action on the lipid metabolism, without detected differences in cardiovascular function or insulin sensitivity.

      This implies that T4 and T3 are not identical, but I want to check the study further to see if half-life comes into play. The T3 group could theoretically have higher daily thyroidergic exposure, but maintain TSH because they experience a daily dip. Multiple dosing at least partly solves this issue. Controlled release tablets would be ideal.

    1. In almost all cases the genetic basis of RTH lies in mutation of the carboxyl-terminus of the ß-thyroid hormone receptor. RTH is a dominant disorder, except in one family; most individuals are heterozygous for the mutant allele.

      So, given that thyroid hormone resistance does exist, the remaining question is whether it is common enough to explain some cases of CFS or similar conditions. Unfortunately this paper is not in english, but the abstract provides enough information to google more.

    1. altered thyroid gland function affects vasopressin and oxytocin release from the hypothalamo-neurohypophysial system in the state of equilibrated water metabolism

      I ought read the full study to see the proposed mechanism. The vasopressin effect is not surprising at all, but the oxytocin effect was unexpected for me. That may be because I know more about vasopressin than I do oxytocin.

  4. Oct 2018
    1. Artifact Type: Syllabus Source URL: http://engl165lg.wordpress.com/ Creator: Amanda Phillips (University of California-Davis)

      interested

    2. Source URL: http://www.auntiepixelante.com/twine/

      note to self

    1. Enjoy this work!
    2. Be ambitious for the work and not for the reward.
    3. Take no notice of anyone you don’t respect.
    4. Never stop when you are stuck. You may not be able to solve the problem, but turn aside and write something else. Do not stop altogether.
    5. Turn up for work. Discipline allows creative freedom. No discipline equals no freedom.
    6. “Perfection is like chasing the horizon. Keep moving.”