8 Matching Annotations
  1. Apr 2021
  2. Mar 2021
    1. Of course, most of your sales won’t come at the full price, but your original price is a starting point and can only go lower. So choose wisely.
  3. Feb 2021
    1. However, sometimes actions can't be rolled back and it is unfortunately unavoidable. For example, consider when we send emails during the call to process. If we send before saving a record and that record fails to save what do we do? We can't unsend that email.
    2. I typically save everything I can first, and then call the side-effects afterwards. If the side-effects fail I can handle them elsewhere and retry when necessary.
  4. Nov 2020
    1. In Angular CLI 1.x (Angular 5) you had ng eject command for this, which was ejecting the whole underlying webpack configuration and allowing you to modify it as you please.
  5. Sep 2020
    1. Amazon pushes teams to escalate one-way door decisions – those that can’t be reversed and may have long-term consequences.  However, with “two-way” decisions, managers are coached to make these decisions themselves.

      Amazon encourages employees to escalate decisions that are irreversible (one-way door decisions) and to delegate decisions that are not. The idea being that if you can act quickly, even if you make more mistakes, it will benefit the system as a whole.

  6. Aug 2018
    1. Dizziness or lightheadedness may be more likely to occur in the elderly, who are more sensitive to the effects of phenoxybenzamine. In addition, phenoxybenzamine may reduce tolerance to cold temperatures in elderly patients.

      Increased sensitivity to cold by phenoxybenzamine could be the result of heat dissipation via peripheral vasodilation.

    1. In these two systems, the alpha 1 adrenergic receptor reappearance followed a monoexponential kinetic allowing to determine the half-life of the receptor (23h in vitro, 33h in vivo) as well as the rate of receptor synthesis and degradation.

      Thus, the effective pharmacological half life of phenoxybenzamine is roughly 1 day.