- May 2024
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the misconception about the relationship between genes and proteins and the idea that it that causality can only go in one direction from Gene to protein to 00:53:06 functionality and that it cannot go back the other way which and that is the crucial thing that denies agency to the organism and that was Watson and Crick
for - critique - of Watson & Cricks DNA - agency of organisms
critique - of Watson & Cricks DNA - agency of organisms - Watson & Cricks advocated the now disproven idea that causality is only one direction - from genes to - proteins to - functionality of living organisms - when in fact, it goes the other way, giving the high level living organism agency
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what actually is so fundamentally wrong with the gene Center view
for - purpose in nature - exorcism of - Ray Noble - quote - gene centered view - organisms as machines - exorcism - Ray Noble - gene centered view
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- Jan 2024
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docdrop.org docdrop.org
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once you dissolve that boundary you can't tell whose memories or who's anymore that's kind of the big thing about um that that kind of memory wiping the the wiping the identity on these 00:06:18 memories is a big part of multicellularity
for - key insight - multicellularity - memory wiping
- key insight
- individuals have information in their memories about survival
- when they merge and join, they pool their information and you can't tell whose memories came from whom initially
- this memory wiping is a key aspect of multcellularity
investigate - salience of memory wiping for multicellularity - This is a very important biological behavior. - Perform a literature review to understand examples of this
question - biological memory wiping - can it be extrapolated to social superorganism?
- key insight
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you have the slime mold and you put a piece of oat which the Slime wants to eat
for - individual or collective behavior - slime mold - prisoner's dilemma and slime molds - slime molds - me vs we - me vs we - slime molds - adjacency - slime molds - me vs we - multicellular organisms
- quote
- You have the slime mold and you put a piece of oat which the Slime wants to eat and
- it starts to crawl towards that oat and then
- What you can do is you can take a razor blade and just cut off that leading edge
- the little piece of it that's moving towards the oat
- Now as soon as you've done that
- that little piece is a new individual and
- it has a decision to make
- it can go in and get the oat and exploit that resource and not have to share it with this giant mass of faizaram that's back here or
- it can first merge back and connect back to the original mass
- because they can reconnect quite easily and then they go get the oat
- Now the thing is that the the payoff Matrix looks quite different because
- when it's by itself it can do this calculus of "well, it's better for me to go get the food instead of and not share it with this other thing"
- but as soon as you connect, that payoff Matrix changes because there is no me and you
- there's just we and at that point it doesn't make any sense to the fact that
- you can't defect against yourself so that payoff table of actions and consequences looks quite different
- because some of the actions change the number of players and
- that's really weird
adjacency between - slime molds - me vs we -multicellular organisms - social superorganism and societal breakdown - adjacency statement - A simple slime mold experiment could make an excellent BEing journey - to demonstrate how multicellular beings operate through higher order organizational principle of collaboration that - keeps cells aligned with a common purpose, - but that each cellular unit also comes equipped with - an evolutionarily inherited legacy of individual control system - normally, the evolutionarily later and higher order collaborative signaling that keeps the multi-cellular being unified overrides the lower order, evolutionarily more primitive autonomous cellular control system - however, pathological conditions can occur that disrupt the collaborative signaling, causing an override condition, and individual cells to revert back to their more primitive legacy survival system - The same principles happen at a societal level. - In a healthy, well-functioning society, the collaborative signaling keeps the society together - but if it is severely disrupted, social order breakdown ensues and - individual human beings and small groups resort to individual survival behavior
- quote
Tags
- individual or collective behavior
- question - extrapolation of biological memory wiping to social superorganism
- investigate - literature review of biological memory wiping in multicellular organisms
- key insight - multicellularity - memory wiping
- me vs we - slime molds
- prisoner's dilemma and slime molds
- slime mold - individual or collective behavior
- slime molds - me vs we
- adjacency - slime molds - me vs we - multicellular organisms - social superorganism
Annotators
URL
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- Oct 2023
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docdrop.org docdrop.org
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Cambrian explosion
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for: Cambrian explosion, 2D to 3D organisms
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insight
- During the Cambrian explosion, there was a major evolutionary transition from bottom dwellers that lived on the flat bottom of the ocean to organisms evolved to explore the entire 3D water column. Some of the evolutionary adaptations that made this possible were
- eyes that supported vision and perception of distance
- representation of space and time
- During the Cambrian explosion, there was a major evolutionary transition from bottom dwellers that lived on the flat bottom of the ocean to organisms evolved to explore the entire 3D water column. Some of the evolutionary adaptations that made this possible were
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www.frontiersin.org www.frontiersin.org
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Eukaryotic single-celled organisms appear in the fossil record perhaps by 1.6 BYA (Knoll et al., 2006). Yet for a “boring billion” years of evolutionary history, they remain minor components in bacterial-dominated ecosystems before explosively radiating as large, multicellular species in an Ediacaran and Cambrian MST. Eukaryotes are obviously essential for this MST, as all animals, plants and fungi are eukaryotes. However, the initial appearance of eukaryotic cells seems insufficient for a MST.
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for: example, example - MET and FET insufficient for MST
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example: MET and FET insufficient for MST
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paraphrase
- Eukaryotic single-celled organisms appear in the fossil record by approx. 1.6 BYA (Knoll et al., 2006).
- Yet for a “boring billion” years of evolutionary history, they remain minor components in bacterial-dominated ecosystems
- before explosively radiating as large, multicellular species in
- an Ediacaran and
- Cambrian MST.
- before explosively radiating as large, multicellular species in
- Eukaryotes are obviously essential for this MST, as all
- animals,
- plants and
- fungi
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are eukaryotes.
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However, the initial appearance of eukaryotic cells seems insufficient for a MST
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- Sep 2023
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Defections from large-scale anatomical goals, such as those that occur due to an inappropriate reduction of gap junctional connectivity [74], present as cancer, cause reversions of cell behavior to ancient unicellular concerns which lead to metastasis and over-proliferation as the cells treat the rest of the body as external environment.
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fresh perspective
- cancer can be interpreted as a breakdown in the bodies multiscale competency architecture causing cancerous cells to lose their higher level synchronizing signals and revert to their more evolutionarily primitive forms as individuals that see the body as simply an external environment
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adjacency between
- gap junction coupling
- cancer
- healthy tissue coherence
- multiscale competency architecture
- adjacency statement
- gap junction coupling appears to be an evolutionary means of cohering individuals together to form a larger group
- hence, they seem to play a critical role in the continued evolution of more complex multicellular organisms
- their pathologies within multicellular beings destroy multicellular structures and create disease, reverting the organism, or competent multicellular structures of the organism such as tissues and organs back to individualistic behavior, as in cancers
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- Aug 2023
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we were designed by you know evolution through evolution we have become we were i really every organism as we'll 00:45:01 talk about in a minute is a problem-solving organism and if i can't solve problems there's like a you know like fundamentally going against the grain of what it means to be an organism
- for: evolutionary design, organisms - problem solving
- key insight
- organisms as evolution's way of solving a specific problem
- hence, organisms are by their very nature, solvers of specific evolutionary problems of how to best adapt to an environment, and that includes our own human species
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- Jul 2023
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www.themarginalian.org www.themarginalian.org
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Ideas have retained some of the properties of organisms. Like them, they tend to perpetuate their structure and to breed; they too can fuse, recombine, segregate their content. Monod said ideas have “spreading power” and propagate “infectivity” — we see this today with the language of “viral” ideas.
Ideas as organisms/virus
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- Jan 2018
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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- Nov 2017
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hw-f5-neoreviews.highwire.org hw-f5-neoreviews.highwire.org
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The acronym TORCH was initially proposed by Andres Nahmias in 1971 to represent 4 congenital infections with a similar clinical presentation, including a rash and ocular findings in neonates: toxoplasmosis, rubella, cytomegalovirus (CMV), and herpes simplex virus (HSV). Over the next few years, the acronym was changed to TORCHES to include syphilis.
The “other” category now includes:
*Lymphocytic Choriomeningitis virus (LCMV)
*Parvovirus B19
*Enteroviruses,
*Varicella-zoster virus
*Epstein-Barr virus
*Human immunodeficiency virus (HIV)
*West Nile virus, and
- Zika virus (ZIKV).
The most complex events in embryogenesis involving the sensory organs take place during the first few weeks of pregnancy, making the eyes and ears particularly vulnerable. The fetus does not have the immunologic mechanisms needed to eliminate the organism, leading to immunologic tolerance and chronic infection.
The most common eye finding of congenital infections is a chorioretinal scar. Congenital cataracts, optic nerve atrophy, or hypoplasia may also be found.
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