5 Matching Annotations
  1. Jun 2019
    1. When we eat at night, our blood glucose, HbA1c and insulin levels increase more and say elevated longer than when we eat earlier in the day, which can result in an elevated risk of type 2 diabetes over time.

      The way this is worded is distracting because (so far as I understand) HbA1c doesn't fluctuate anywhere near as quickly as blood glucose and insulin.

    1. rhythms in the uptake of the glucose analog 2-deoxyglucose (2-DG) precede the development of a functional TTFL

      This could be interesting as well. Metabolic issues run through chronic illness. As do circadian dysfunctions, diabetes susceptibility,

  2. Jan 2018
    1. An interactive network of bibliographic connections between some central proteins of the circadian clock, along with links to some major model organisms.

      Circadian clock proteins

  3. Oct 2017
    1. Beta blockers have long been associated with sleep disturbances such as difficulty falling asleep, staying asleep, and insomnia. They have been shown to reduce the production of melatonin via specific inhibition of beta-1 adrenergic receptors. Melatonin is a hormone secreted by the pineal gland in the brain, and helps in maintaining normal circadian rhythms.6,20-21 People with hypertension already have a lower melatonin production rate than those with normal blood pressure.22

      The question becomes, then, do beta blockers impair sleep when exogenous melatonin is administered concurrently?