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  1. Oct 2017
    1. . Although site-specific conjugation strategies have been developed that improve the yield and specificity of the conjugation site5,6, issues remain with the cost and intrinsic heterogeneity of the PEG itself7.

      peg heterogeneity

    2. Renally cleared PEGylated proteins or their metabolites may accumu-late in the kidney, causing formation of PEG hydrates that interfere with normal glomerular filtration. In addition, animals and humans can be induced to make antibodies to PEG9,10

      kidney accumulation, anti-peg antibodies

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  2. Dec 2016
    1. Written by rchase, feel free to edit. It's an experiment.

      Since I took the notes using hypothesis, the password to edit is hypothesis.