7 Matching Annotations
  1. Sep 2019
    1. Signaling triggers an extensive rearrangement of receptors and cytoskeletal changes that culminate in the establishment of a transient cell polarity with the assembly of a specialized structure, known as the immunological synapse (

      The use of the term polarity has been confusing. But, it appears that the homology can be retined

  2. Jan 2019
  3. Oct 2017
    1. efficiently mitigated by dexamethasone which does not influence BiTE®-induced T-cell activation and redirected lysis

      dexamethasone can reduce immune response

    2. Upon synapse formation, T cells not only release perforin and granzyme B but also release large amounts of cytokines, namely interleukin (IL)-6, IL-10, and interferon (IFN)-γ
    3. 10–15 of these interactions lead to the formation of a cytolytic synapse much like a pMHC-TCR interaction-based immunologic synapse between an antigen-presenting cell and a T cell [15]