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  1. Jun 2025
  2. elifesciences.org elifesciences.org
    Sigh generation in preBötzinger complex
    6
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    elifesciences.org/articles/100192
  3. elifesciences.org elifesciences.org
    Striatal cholinergic interneuron pause response requires Kv1 channels, is absent in dyskinetic mice, and is restored by dopamine D5 receptor inverse agonism
    5
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    elifesciences.org/articles/102184
  4. elifesciences.org elifesciences.org
    Dynamics of venom composition across a complex life cycle
    7
    1. vmorrand 25 Jun 2025
      Our finding of different expression levels of toxins in different developmental stages and adult tissues strongly suggests that venom composition changes across development and that each arsenal of toxins might have been shaped by selection for different biotic interactions. As Nematostella develops from a non-predatory, swimming larva to an adult sessile predatory polyp that is 150-fold larger than the larva (Figure 1A), its interspecific interactions vastly change across development.

      This makes sense because just as humans change and develop across different stages of life, venom composition would do the same

    2. vmorrand 25 Jun 2025
      The results of the experiments showed that Nematostella mothers pass on a toxin to their eggs that makes them unpalatable to predators.

      That is a very interesting finding because being able to pass along this toxin from mothers to their eggs is not something I think I have ever heard of to keep predators away.

    3. EliannyG 24 Jun 2025
      Variation in expression patterns of the NEP3 family members and the fact that at least four different types of gland cells at distinct developmental stages and tissues express different toxins (Nv1, Nvlysin1b, NEP6 and NvePTx1) in Nematostella suggests a highly complex venom landscape in this species

      Maybe this variety and diversity potentially keeps prey from getting used to the venom.

    4. EliannyG 24 Jun 2025
      The results of the ISH and nCounter experiments indicated that NvePTx1 is maternally deposited at the RNA level.

      It makes sense that the venom isn't made by the larvae with the mother providing this to them so they can hunt right away.

    5. EliannyG 24 Jun 2025
      Strikingly, within 10 min from the start of the incubation 3 out of 8 Artemia were paralyzed or dead, and within 90 min 7 of 8 were dead (Video 1), whereas in a control group without planulae all Artemia were alive.

      I find it impressive that such a small larva can kill something bigger. This shows it probably has very strong venom.

    6. EliannyG 24 Jun 2025
      change dramatically between developmental stages of this species

      I wonder if this variation in venom could be linked to specific prey types available at each stage.

    7. hanadp26 16 Jun 2025
      We find that venom composition and arsenal of toxin-producing cells change dramatically between developmental stages of this species.

      Interesting that venom changes as the animal grows.

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    elifesciences.org/articles/35014
  5. elifesciences.org elifesciences.org
    The Natural History of Model Organisms: The secret lives of Drosophila flies
    6
    1. Kevingomezgg 25 Jun 2025
      Approximately 65% of human disease genes are estimated to have counterparts in D. melanogaster

      This demonstrates the genetic similarity between D. melanogaster and humans, reinforcing its value as a model organism for studying human disease mechanisms.

    2. Kevingomezgg 25 Jun 2025
      Few studies of D. melanogaster have been done in the wild, but those that have reveal a different picture of wild flies.

      This highlights the research gap between laboratory and field studies. Understanding wild populations is important to get a complete picture of the species' biology and evolution.

    3. dmays 24 Jun 2025
      The genes that control these behavioural differences can hold clues to controlling the reproduction of economically and medically important insects, such as testse flies and mosquitoes

      Understanding the genetic basis of reproductive behaviors could inform pest control strategies to reduce disease transmission and crop damage.

    4. dmays 24 Jun 2025
      Reproductive behavior and biology, while extensively studied in the laboratory, is less well-understood in the wild.

      Laboratory conditions often simplify or alter natural behaviors, so findings may not fully reflect what occurs in nature.

    5. Soniaghill 15 Jun 2025
      holometabolous,

      Other insects that are considered holometabolous include some common ones such as: house flies, mosquitoes, gnats, monarch butterflies and some moths. Both the larvae and adults occupy the decaying source at different time frames which allows the interactions between the microbes.

    6. Soniaghill 15 Jun 2025
      D. melanogaster do not live alone. Their decaying host resources are also home to many microbes, as well as to other arthropods, including other Drosophila species, all of which they interact with (see Video 1, 2). Some microbes in the decaying material themselves provide food for D. melanogaster, being selectively consumed by larvae or adults

      The microbes not only live in this environment, but also serve as a food source for the flies. This explains how the D. melanogaster depend on other organisms in their habitat.

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    elifesciences.org/articles/06793
  6. elifesciences.org elifesciences.org
    A direct neural signature of serial dependence in working memory
    8
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    elifesciences.org/articles/99478
  7. elifesciences.org elifesciences.org
    A temporally restricted function of the Dopamine receptor Dop1R2 during memory formation
    6
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    elifesciences.org/reviewed-preprints/99368
  8. elifesciences.org elifesciences.org
    Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release
    30
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    elifesciences.org/reviewed-preprints/107276
  9. elifesciences.org elifesciences.org
    Local Inhibitory Dynamics Underpin Temporal Integration and Functional Segregation between Barrels and Septa in the Mouse Barrel Cortex
    4
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    elifesciences.org/reviewed-preprints/107099
  10. elifesciences.org elifesciences.org
    Mapping HIV-1 RNA structure, homodimers, long-range interactions and persistent domains by HiCapR
    1
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    elifesciences.org/articles/102550
  11. elifesciences.org elifesciences.org
    A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality
    1
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    elifesciences.org/articles/105422
  12. elifesciences.org elifesciences.org
    Human formin FHOD3-mediated actin elongation is required for sarcomere integrity in cardiomyocytes
    1
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    elifesciences.org/reviewed-preprints/104048
  13. elifesciences.org elifesciences.org
    Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
    5
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    elifesciences.org/articles/100604
  14. elifesciences.org elifesciences.org
    BCAS2 promotes primitive hematopoiesis by sequestering β-catenin within the nucleus
    20
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    elifesciences.org/articles/100497
  15. elifesciences.org elifesciences.org
    Behavioural and neurogenetic evidence for emotion primitives in the fruit fly Drosophila: insights from the Open Field Test
    2
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    elifesciences.org/reviewed-preprints/107110
  16. elifesciences.org elifesciences.org
    Targeted protein degradation by KLHDC2 ligands identified by high-throughput screening
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    elifesciences.org/articles/106844
  17. elifesciences.org elifesciences.org
    Barcode-free multiplex plasmid sequencing using Bayesian analysis and nanopore sequencing
    3
    1. pbk1 12 Jun 2025
      taking fully advantage of our algorithm might involve coordination between multiple colleagues in a lab who are constructing plasmids with different expected sequences.

      This is something a local core like GCEC can help with

    2. pbk1 12 Jun 2025
      it could be further reduced by executing time-consuming dynamic programming only for some query-reference pairs that necessitate high levels of accuracy and by introducing parallel computing

      Nice, Any other ideas to reduce RAM use?

    3. pbk1 12 Jun 2025
      theoretical minimum number of reads that is required for the reliable consensus calculation is 30 reads per plasmid

      Does this depend on the plasmid length and the preperation kit before sequencing that determines fragmentation?

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    elifesciences.org/reviewed-preprints/88794v1
  18. elifesciences.org elifesciences.org
    Micro-Scale Control of Oligodendrocyte Morphology and Myelination by the Intellectual Disability-Linked Protein Acyltransferase ZDHHC9
    4
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    elifesciences.org/reviewed-preprints/97151
  19. elifesciences.org elifesciences.org
    Assessment of the histone mark-based epigenomic landscape in human myometrium at term pregnancy
    2
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    elifesciences.org/articles/95897
  20. elifesciences.org elifesciences.org
    Occupancy of the HbYX hydrophobic pocket is sufficient to induce gate opening in the archaeal 20S proteasomes
    1
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    elifesciences.org/reviewed-preprints/106611
  21. elifesciences.org elifesciences.org
    A Commander-independent function of COMMD3 in endosomal trafficking
    21
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    elifesciences.org/reviewed-preprints/105264
  22. elifesciences.org elifesciences.org
    Mixed representations of choice direction and outcome by GABA/glutamate cotransmitting neurons in the entopeduncular nucleus
    7
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    elifesciences.org/reviewed-preprints/100488
  23. elifesciences.org elifesciences.org
    CellSeg3D: self-supervised 3D cell segmentation for fluorescence microscopy
    3
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    elifesciences.org/reviewed-preprints/99848v3
  24. elifesciences.org elifesciences.org
    A direct neural signature of serial dependence in working memory
    2
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    elifesciences.org/reviewed-preprints/99478v2
  25. elifesciences.org elifesciences.org
    Switching perspective: Comparing ground-level and bird’s-eye views for bumblebees navigating dense environments
    2
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    elifesciences.org/reviewed-preprints/99140v2
  26. elifesciences.org elifesciences.org
    Predictive models for secondary epilepsy within 1 year in patients with acute ischemic stroke: a multicenter retrospective study
    1
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    elifesciences.org/reviewed-preprints/98759v2
  27. elifesciences.org elifesciences.org
    Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease
    10
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    elifesciences.org/reviewed-preprints/98558v2
  28. elifesciences.org elifesciences.org
    Whole-body connectome of a segmented annelid larva
    2
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    elifesciences.org/reviewed-preprints/97964v2
  29. elifesciences.org elifesciences.org
    A modular platform to display multiple hemagglutinin subtypes on a single immunogen
    1
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    elifesciences.org/reviewed-preprints/97364v2
  30. elifesciences.org elifesciences.org
    Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants
    4
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    elifesciences.org/reviewed-preprints/97341v2
  31. elifesciences.org elifesciences.org
    Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning
    2
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    elifesciences.org/reviewed-preprints/97330v2
  32. elifesciences.org elifesciences.org
    Structure, function and assembly of soybean primary cell wall cellulose synthases
    6
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    elifesciences.org/reviewed-preprints/96704v2
  33. elifesciences.org elifesciences.org
    Shortcutting from self-motion signals: quantifying trajectories and active sensing in an open maze
    3
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    elifesciences.org/reviewed-preprints/95764v3
  34. elifesciences.org elifesciences.org
    Crosslinking by ZapD drives the assembly of short FtsZ filaments into toroidal structures in solution
    5
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    elifesciences.org/reviewed-preprints/95557v2
  35. elifesciences.org elifesciences.org
    An Hfq-dependent post-transcriptional mechanism fine tunes RecB expression in Escherichia coli
    1
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    elifesciences.org/reviewed-preprints/94918v2
  36. elifesciences.org elifesciences.org
    Shaping the physical world to our ends: The left PF technical-cognition area
    2
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    elifesciences.org/reviewed-preprints/94578v2
  37. elifesciences.org elifesciences.org
    Prolonged Cell Cycle Arrest in Response to DNA damage in Yeast Requires the Maintenance of DNA Damage Signaling and the Spindle Assembly Checkpoint
    6
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    elifesciences.org/reviewed-preprints/94334v2
  38. elifesciences.org elifesciences.org
    A Novel Mouse Model for LAMA2-Related Muscular Dystrophy: Analysis of Molecular Pathogenesis and Clinical Phenotype
    8
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    elifesciences.org/reviewed-preprints/94288v2
  39. elifesciences.org elifesciences.org
    Bridging the gap between presynaptic hair cell function and neural sound encoding
    1
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    elifesciences.org/reviewed-preprints/93749v2