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  1. Jun 2022
  2. elifesciences.org elifesciences.org
    METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance
    16
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    elifesciences.org/articles/72780
  3. elifesciences.org elifesciences.org
    Dynamic spreading of chromatin-mediated gene silencing and reactivation between neighboring genes in single cells
    24
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    elifesciences.org/articles/75115
  4. elifesciences.org elifesciences.org
    Dnmt3a knockout in excitatory neurons impairs postnatal synapse maturation and increases the repressive histone modification H3K27me3
    31
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    elifesciences.org/articles/66909
  5. elifesciences.org elifesciences.org
    Modified viral-genetic mapping reveals local and global connectivity relationships of ventral tegmental area dopamine cells
    8
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    elifesciences.org/articles/76886
  6. elifesciences.org elifesciences.org
    Drosophila gustatory projections are segregated by taste modality and connectivity
    26
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    elifesciences.org/articles/78110
  7. elifesciences.org elifesciences.org
    Quantitative mapping of human hair greying and reversal in relation to life stress
    1
    1. chrisaldrich 01 Jun 2022
      Using this method, we show white/grey hairs that naturally regain pigmentation across sex, ethnicities, ages, and body regions, thereby quantitatively defining the reversibility of greying in humans. Molecularly, grey hairs upregulate proteins related to energy metabolism, mitochondria, and antioxidant defenses. Combining HPP profiling and proteomics on single hairs, we also report hair greying and reversal that can occur in parallel with psychological stressors. To generalize these observations, we develop a computational simulation, which suggests a threshold-based mechanism for the temporary reversibility of greying.

      https://elifesciences.org/articles/67437

      Researchers have shown that some types of greying hair are reversible.

      grey hair
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    elifesciences.org/articles/67437
  8. May 2022
  9. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Wnt11 acts on dermomyotome cells to guide epaxial myotome morphogenesis
    5
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    pubmed.ncbi.nlm.nih.gov/35522214/
  10. elifesciences.org elifesciences.org
    Working with Bio-protocol to publish peer-reviewed protocols
    1
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    elifesciences.org/inside-elife/ab137ad4/working-with-bio-protocol-to-publish-peer-reviewed-protocols
  11. Apr 2022
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An auxin-inducible, GAL4-compatible, gene expression system for Drosophila
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8975555/
  13. elifesciences.org elifesciences.org
    VIP interneurons in mouse primary visual cortex selectively enhance responses to weak but specific stimuli
    1
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    elifesciences.org/articles/55130
  14. elifesciences.org elifesciences.org
    SpikeInterface, a unified framework for spike sorting
    1
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    elifesciences.org/articles/61834
  15. elifesciences.org elifesciences.org
    Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex
    1
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    elifesciences.org/articles/68802
  16. elifesciences.org elifesciences.org
    Robust and annotation-free analysis of alternative splicing across diverse cell types in mice
    1
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    elifesciences.org/articles/73520
  17. Mar 2022
  18. elifesciences.org elifesciences.org
    A robust and tunable mitotic oscillator in artificial cells
    1
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    elifesciences.org/articles/33549
  19. Feb 2022
  20. elifesciences.org elifesciences.org
    The human coronavirus HCoV-229E S-protein structure and receptor binding
    5
    4. jackiekrauss 21 Feb 2022
      The coronavirus S-protein mediates receptor binding and fusion of the viral and host cell membranes. In HCoV-229E, its receptor binding domain (RBD) shows extensive sequence variation but how S-protein function is maintained is not understood. Reported are the X-ray crystal structures of Class III-V RBDs in complex with human aminopeptidase N (hAPN), as well as the electron cryomicroscopy structure of the 229E S-protein. The structures show that common core interactions define the specificity for hAPN and that the peripheral RBD sequence variation is accommodated by loop plasticity. The results provide insight into immune evasion and the cross-species transmission of 229E and related coronaviruses. We also find that the 229E S-protein can expose a portion of its helical core to solvent. This is undoubtedly facilitated by hydrophilic subunit interfaces that we show are conserved among coronaviruses. These interfaces likely play a role in the S-protein conformational changes associated with membrane fusion.
      ann:summary
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    elifesciences.org/articles/51230
  21. elifesciences.org elifesciences.org
    Dual roles for ATP in the regulation of phase separated protein aggregates in Xenopus oocyte nucleoli
    8
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    elifesciences.org/articles/35224
  22. elifesciences.org elifesciences.org
    Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis
    6
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    elifesciences.org/articles/02996
  23. Jan 2022
  24. elifesciences.org elifesciences.org
    Evolutionary transcriptomics implicates new genes and pathways in human pregnancy and adverse pregnancy outcomes
    9
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    elifesciences.org/articles/69584
  25. elifesciences.org elifesciences.org
    Reproducibility in Cancer Biology: Challenges for assessing replicability in preclinical cancer biology
    1
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    elifesciences.org/articles/67995
  26. elifesciences.org elifesciences.org
    eLife and Medicine: Rigorous review and editorial oversight of clinical preprints
    3
    1. wangtaotao 03 Jan 2022
      Such opportunities and challenges, best illustrated during the pandemic, lie ahead as medicine moves towards the goal of providing evidence-based care to patients no matter where they live. This trajectory also opens up real opportunities for speed, transparency and rich evaluation across peer review in medicine.

      呼吁医学界提供更为快速、透明、评估更为全面的同行评审创造需求

    2. wangtaotao 03 Jan 2022
      But even as the pandemic has demonstrated the potential for rapid, author-driven publication to democratize access and accelerate research, it has exposed the challenges of this model of scholarly communication

      作者驱动的快速出版 面向大众开放 促进研究

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    elifesciences.org/articles/67528
  27. Dec 2021
  28. elifesciences.org elifesciences.org
    Specialized neurons in the right habenula mediate response to aversive olfactory cues
    9
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    elifesciences.org/articles/72345
  29. elifesciences.org elifesciences.org
    IL-2/JES6-1 mAb complexes dramatically increase sensitivity to LPS through IFN-γ production by CD25+Foxp3- T cells
    29
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    elifesciences.org/articles/62432
  30. elifesciences.org elifesciences.org
    Light sets the brain’s daily clock by regional quickening and slowing of the molecular clockworks at dawn and dusk
    4
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    elifesciences.org/articles/70137
  31. homandev.pressbooks.network homandev.pressbooks.network
    Webinar Report: Being a scientist and a parent
    1
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    homandev.pressbooks.network/emptybook/
  32. Nov 2021
  33. elifesciences.org elifesciences.org
    Research Culture: Creating SPACE to evolve academic assessment
    6
    1. dasaptaerwin 10 Nov 2021
      it is designed to help institutional leaders reflect on the extent to which their organization can support sustained and values-driven assessment practices, and where they might focus efforts to further evolve them.

      SPACE to support sustained and values-driven assessment practices.

      research culture
    5. dasaptaerwin 10 Nov 2021
      Rather, it is due to a growing reliance on proxy measures of research quality in the management of recruitment, promotion, tenure and funding decisions: these proxy measures are widely used because they are convenient, not because they are meaningful. The pursuit of a higher ranking in league tables for universities has also contributed to the problem.

      proxy measures >> convenient but not meaningful

      research culture proxy
    6. dasaptaerwin 10 Nov 2021
      Ghent University in Belgium made headlines in 2019 when it announced a new policy for evaluating faculty that marked a shift away from the 'rat race' of metrics and rankings towards more holistic processes focused on valuing and nurturing talent

      notice >> rat race

      research culture
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    elifesciences.org/articles/70929
  34. Sep 2021
  35. elifesciences.org elifesciences.org
    Single-molecule observation of ATP-independent SSB displacement by RecO in Deinococcus radiodurans
    1
    1. aksmit22 22 Sep 2021
      However, the entire repair process for DSBs is notably more efficient in DR than in other organisms; DR is able to restore hundreds of copies of damaged double strands in an hour

      I guess that answers my last question, but raises another question: what allows the repair process to only be most efficient in DR than other organisms, could there be some other important aspect involved in the mechanism?

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    elifesciences.org/articles/50945