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  1. Aug 2022
  2. elifesciences.org elifesciences.org
    A neural progenitor mitotic wave is required for asynchronous axon outgrowth and morphology
    6
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    elifesciences.org/articles/75746
  3. Jul 2022
  4. elifesciences.org elifesciences.org
    Analysis of rod/cone gap junctions from the reconstruction of mouse photoreceptor terminals
    2
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    elifesciences.org/articles/73039
  5. Jun 2022
  6. elifesciences.org elifesciences.org
    Magnetic stimulation allows focal activation of the mouse cochlea
    2
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    elifesciences.org/articles/76682
  7. elifesciences.org elifesciences.org
    Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome
    7
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    elifesciences.org/articles/75166
  8. elifesciences.org elifesciences.org
    METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance
    23
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    elifesciences.org/articles/72780
  9. elifesciences.org elifesciences.org
    Dynamic spreading of chromatin-mediated gene silencing and reactivation between neighboring genes in single cells
    24
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    elifesciences.org/articles/75115
  10. elifesciences.org elifesciences.org
    Dnmt3a knockout in excitatory neurons impairs postnatal synapse maturation and increases the repressive histone modification H3K27me3
    31
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    elifesciences.org/articles/66909
  11. elifesciences.org elifesciences.org
    Modified viral-genetic mapping reveals local and global connectivity relationships of ventral tegmental area dopamine cells
    8
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    elifesciences.org/articles/76886
  12. elifesciences.org elifesciences.org
    Drosophila gustatory projections are segregated by taste modality and connectivity
    26
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    elifesciences.org/articles/78110
  13. elifesciences.org elifesciences.org
    Quantitative mapping of human hair greying and reversal in relation to life stress
    1
    1. chrisaldrich 01 Jun 2022
      Using this method, we show white/grey hairs that naturally regain pigmentation across sex, ethnicities, ages, and body regions, thereby quantitatively defining the reversibility of greying in humans. Molecularly, grey hairs upregulate proteins related to energy metabolism, mitochondria, and antioxidant defenses. Combining HPP profiling and proteomics on single hairs, we also report hair greying and reversal that can occur in parallel with psychological stressors. To generalize these observations, we develop a computational simulation, which suggests a threshold-based mechanism for the temporary reversibility of greying.

      https://elifesciences.org/articles/67437

      Researchers have shown that some types of greying hair are reversible.

      grey hair
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    elifesciences.org/articles/67437
  14. May 2022
  15. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Wnt11 acts on dermomyotome cells to guide epaxial myotome morphogenesis
    5
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    pubmed.ncbi.nlm.nih.gov/35522214/
  16. elifesciences.org elifesciences.org
    Working with Bio-protocol to publish peer-reviewed protocols
    1
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    elifesciences.org/inside-elife/ab137ad4/working-with-bio-protocol-to-publish-peer-reviewed-protocols
  17. Apr 2022
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An auxin-inducible, GAL4-compatible, gene expression system for Drosophila
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8975555/
  19. elifesciences.org elifesciences.org
    VIP interneurons in mouse primary visual cortex selectively enhance responses to weak but specific stimuli
    1
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    elifesciences.org/articles/55130
  20. elifesciences.org elifesciences.org
    SpikeInterface, a unified framework for spike sorting
    1
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    elifesciences.org/articles/61834
  21. elifesciences.org elifesciences.org
    Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex
    1
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    elifesciences.org/articles/68802
  22. elifesciences.org elifesciences.org
    Robust and annotation-free analysis of alternative splicing across diverse cell types in mice
    1
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    elifesciences.org/articles/73520
  23. Mar 2022
  24. elifesciences.org elifesciences.org
    A robust and tunable mitotic oscillator in artificial cells
    1
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    elifesciences.org/articles/33549
  25. Feb 2022
  26. elifesciences.org elifesciences.org
    The human coronavirus HCoV-229E S-protein structure and receptor binding
    5
    4. jackiekrauss 21 Feb 2022
      The coronavirus S-protein mediates receptor binding and fusion of the viral and host cell membranes. In HCoV-229E, its receptor binding domain (RBD) shows extensive sequence variation but how S-protein function is maintained is not understood. Reported are the X-ray crystal structures of Class III-V RBDs in complex with human aminopeptidase N (hAPN), as well as the electron cryomicroscopy structure of the 229E S-protein. The structures show that common core interactions define the specificity for hAPN and that the peripheral RBD sequence variation is accommodated by loop plasticity. The results provide insight into immune evasion and the cross-species transmission of 229E and related coronaviruses. We also find that the 229E S-protein can expose a portion of its helical core to solvent. This is undoubtedly facilitated by hydrophilic subunit interfaces that we show are conserved among coronaviruses. These interfaces likely play a role in the S-protein conformational changes associated with membrane fusion.
      ann:summary
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    elifesciences.org/articles/51230
  27. elifesciences.org elifesciences.org
    Dual roles for ATP in the regulation of phase separated protein aggregates in Xenopus oocyte nucleoli
    8
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    elifesciences.org/articles/35224
  28. elifesciences.org elifesciences.org
    Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis
    6
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    elifesciences.org/articles/02996
  29. Jan 2022
  30. elifesciences.org elifesciences.org
    Evolutionary transcriptomics implicates new genes and pathways in human pregnancy and adverse pregnancy outcomes
    9
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    elifesciences.org/articles/69584
  31. elifesciences.org elifesciences.org
    Reproducibility in Cancer Biology: Challenges for assessing replicability in preclinical cancer biology
    1
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    elifesciences.org/articles/67995
  32. elifesciences.org elifesciences.org
    eLife and Medicine: Rigorous review and editorial oversight of clinical preprints
    3
    1. wangtaotao 03 Jan 2022
      Such opportunities and challenges, best illustrated during the pandemic, lie ahead as medicine moves towards the goal of providing evidence-based care to patients no matter where they live. This trajectory also opens up real opportunities for speed, transparency and rich evaluation across peer review in medicine.

      呼吁医学界提供更为快速、透明、评估更为全面的同行评审创造需求

    2. wangtaotao 03 Jan 2022
      But even as the pandemic has demonstrated the potential for rapid, author-driven publication to democratize access and accelerate research, it has exposed the challenges of this model of scholarly communication

      作者驱动的快速出版 面向大众开放 促进研究

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    elifesciences.org/articles/67528
  33. Dec 2021
  34. elifesciences.org elifesciences.org
    Specialized neurons in the right habenula mediate response to aversive olfactory cues
    8
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    elifesciences.org/articles/72345
  35. elifesciences.org elifesciences.org
    IL-2/JES6-1 mAb complexes dramatically increase sensitivity to LPS through IFN-γ production by CD25+Foxp3- T cells
    18
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    elifesciences.org/articles/62432