On 2014 Jan 07, Brett Snodgrass commented:

Dear Author,

Thank you for the excellent article. Although the fistula closed without a specific ligation procedure, the three procedures probably altered the hemodynamics of the right ventricle and permitted the vessel of Wearn to become less prominent and/or close. The closure may be physiologic or anatomic, and I do not think we have sufficient information to make a definitive determination. The closure would probably be considered anatomic if the vessel lumen became fibrosed.

Please consider viewing the following post related to this article.

https://twitter.com/BrettSnodgrass1/status/415904348074287105

Comments and feedback are welcome.

Thank you kindly.

On 2014 Feb 27, George W Hinkal commented:

The National Cancer Institute has been investing in the development of an online webportal of curated cancer nanotechnology data called caNanoLab. The numerical data, nanomaterial characterizations and composition information for the ten nanoparticles related to this publication have been added to the database and can be found at:

https://cananolab.nci.nih.gov/caNanoLab/characterization.do?dispatch=summaryView&sampleId=33161216&page=0&tab=ALL

https://cananolab.nci.nih.gov/caNanoLab/characterization.do?dispatch=summaryView&sampleId=33161218&page=0&tab=ALL

https://cananolab.nci.nih.gov/caNanoLab/characterization.do?dispatch=summaryView&sampleId=33161217&page=0&tab=ALL

https://cananolab.nci.nih.gov/caNanoLab/characterization.do?dispatch=summaryView&sampleId=33161226&page=0&tab=ALL

https://cananolab.nci.nih.gov/caNanoLab/characterization.do?dispatch=summaryView&sampleId=33161221&page=0&tab=ALL

https://cananolab.nci.nih.gov/caNanoLab/characterization.do?dispatch=summaryView&sampleId=33161222&page=0&tab=ALL

https://cananolab.nci.nih.gov/caNanoLab/characterization.do?dispatch=summaryView&sampleId=33685522&page=0&tab=ALL

https://cananolab.nci.nih.gov/caNanoLab/characterization.do?dispatch=summaryView&sampleId=33161224&page=0&tab=ALL

https://cananolab.nci.nih.gov/caNanoLab/characterization.do?dispatch=summaryView&sampleId=33161225&page=0&tab=ALL

https://cananolab.nci.nih.gov/caNanoLab/characterization.do?dispatch=summaryView&sampleId=34766848&page=0&tab=ALL

The left navigation links on these pages provide information about each sample (under Navigation Tree).

For general information on how to use caNanoLab, please visit https://cananolab.nci.nih.gov/caNanoLab/home.jsp

On 2014 Mar 12, George W Hinkal commented:

None

On 2014 Mar 05, Gwinyai Masukume commented:

In the introduction of this article, the authors state: “We report the largest case series of advanced abdominal pregnancies from sub-Saharan Africa from 1976 to 2006.” This case series has 20 patients.

In 1989, in the article below originating from Africa, South of the Sahara, 23 cases were described. This would thus be the ‘largest case series of advanced abdominal pregnancy from sub-Saharan Africa between 1976 and 2006’.

White RG. Advanced abdominal pregnancy--a review of 23 cases. Ir J Med Sci. 1989; 158(4):77-8. White RG, 1989

On 2015 Mar 17, Ivan Oransky commented:

This paper has been retracted, the second retraction by the same group: http://retractionwatch.com/2015/03/17/cell-biologists-in-south-korea-retract-two-papers/

On 2016 Aug 23, Ben Goldacre commented:

This trial has the wrong trial registry ID associated with it on PubMed: both in the XML on PubMed, and in the originating journal article. The ID given is NCT002289835. We believe the correct ID, which we have found by hand searching, is NCT00289835.

This comment is being posted as part of the OpenTrials.net project^[1] , an open database threading together all publicly accessible documents and data on each trial, globally. In the course of creating the database, and matching documents and data sources about trials from different locations, we have identified various anomalies in datasets such as PubMed, and in published papers. Alongside documenting the prevalence of problems, we are also attempting to correct these errors and anomalies wherever possible, by feeding back to the originators. We have corrected this data in the OpenTrials.net database; we hope that this trial’s text and metadata can also be corrected at source, in PubMed and in the accompanying paper.

Many thanks,

Jessica Fleminger, Ben Goldacre*

[1] Goldacre, B., Gray, J., 2016. OpenTrials: towards a collaborative open database of all available information on all clinical trials. Trials 17. doi:10.1186/s13063-016-1290-8 PMID: 27056367

* Dr Ben Goldacre BA MA MSc MBBS MRCPsych<br> Senior Clinical Research Fellow<br> ben.goldacre@phc.ox.ac.uk<br> www.ebmDataLab.net<br> Centre for Evidence Based Medicine<br> Department of Primary Care Health Sciences<br> University of Oxford<br> Radcliffe Observatory Quarter<br> Woodstock Road<br> Oxford OX2 6GG

On 2016 Jan 12, Peter Gøtzsche commented:

The odds ratio for death was 1.95 (95% confidence interval 1.21 to 3.14), when psychotic patients received 3 or more antipsychotics simultaneously instead of one, thus doubling the mortality. However, the authors adjusted for somatic comedication and the adjusted odds ratio was 1.16 (0.68 to 2.00). This is a fatal error. The death rate soared, the more drugs for somatic illnesses, the patients received (27 times if they received at least 10), and the use of, for example, cardiovascular drugs were 37% and 16% among those who died and those who survived (controls), respectively. The use of diabetes drugs was 12% and 6%, respectively. Since increased doses and the use of several antipsychotics simultaneously increase the incidence of somatic illnesses, it is blatantly wrong to adjust for the use of somatic comedication, as this is part of the causal chain from psychosis to death. In this manner, the adjustment removes a relation between polypharmacy and death that actually exists.

Better studies have shown that polypharmacy with antipsychotics increases deaths, as expected. Some of these studies are mentioned in the current study’s Discussion section.

Peter C Gøtzsche, Professor and Director, Nordic Cochrane Centre

On 2015 Aug 21, Bill Cayley commented:

A good example of when the simpler approach is just as good or better (when less is more) - for more on this, see: https://lessismoreebm.wordpress.com/

On 2016 Oct 03, Morten Oksvold commented:

Please note that after an investigation at the University of Cologne, six articles where T. Wenz figures as first or senior author were found to contain questionable data due to scientific misconduct. This article is one of these six articles.

The conclusion from the report was ready June 28, 2016, please see the link (in German):

http://www.portal.uni-koeln.de/9015.html?&tx_news_pi1[news]=4335&tx_news_pi1[controller]=News&tx_news_pi1[action]=detail&cHash=1deb8399d7f796d65ca9f6ae4764a1ce

On 2013 Oct 23, ANDREW SU commented:

!MOVED http://biogps.org

The URL in the original abstract has now been retired. This data set (together with other gene expression data sets) are now hosted at http://biogps.org.

On 2014 Jul 04, Ferenc Zsila commented:

In page 583, the authors claim that "We also examined anthocyanidin–DNA interactions spectrophotometrically at pH 7.5 but were unable to demonstrate significant or consistent shifts in l max or maximum absorbance that would indicate the interaction between the two at this pH as has been observed for other flavonoids (Webb and Ebeler 2004)."

However, all details of the spectrophotometric measurements are missing from the experimental section. Name and concentration of the tested anthocyanidin(s), concentration of the DNA, temperature, solvent, optical pathlength, wavelength range, and the type of the instrument used all remain unknown. Additionally, the absorption spectra are not shown either.

On 2013 Dec 30, Keizo Takao commented:

The raw data of behavioral tests, which are not described in this paper, are shown in the Mouse Phenotype Database (http://www.mouse-phenotype.org/). "ImageTM", image analysis application software used in this article, is now freely available from http://www.mouse-phenotype.org/software.html.

On 2014 Nov 30, Diego Mauricio Riaño-Pachón commented:

Some of the fl-cDNA sequences appear to have originated from mice/rat instead of maize. Genbank had started to remove some of these entries.

On 2013 Oct 31, John Cannell commented:

I congratulate the authors on a fine study. I wonder if they know that a recent meta-analysis found the the risk of preeclampsia is inversely related to maternal 25(OH)D levels?

Tabesh M, 2013

If not, it shows how little communication is occurring between autism spectrum disorder (ASD) scientists and the broader scientific realm. Each ASD scientist seems to be immersed in his or her own research interest but seemingly oblivious to the larger body of science research.

Thus the vitamin D theory of ASD (vitamin D deficiency being the environmental risk factor for this highly heritable disorder) is consistent with the authors work. Three recent studies, using community controls, have found 25(OH)D levels are significantly lower in children with ASD. Two of the studies below (Mostafa et al and Gong et al) also found ASD severity, as rated on standard ASD rating scales, is inversely correlated with 25(OH)D levels. Mostafa et al found an R value of -.86 for the association of serum 25(OH)D with ASD severity.

Gong ZL, Luo CM, Wang L, Shen L, Wei F, Tong RJ, Liu Y. Serum 25-hydroxyvitamin D levels in Chinese children with autism spectrum disorders. Neuroreport. 2013 Oct 1. Gong ZL, 2014

Meguid NA, Hashish AF, Anwar M, Sidhom G. Reduced serum levels of 25-hydroxy and 1,25-dihydroxy vitamin D in Egyptian children with autism. J Altern Complement Med. 2010 Jun;16(6):641-5. Meguid NA, 2010

Mostafa GA, Al-Ayadhi LY.Reduced serum concentrations of 25-hydroxy vitamin D in children with autism: relation to autoimmunity. J Neuroinflammation. 2012 Aug 17;9:201. Mostafa GA, 2012

There is a plethora of basic science explaining why low gestational or early childhood 25(OH)D levels would adversely effect brain development.

DeLuca GC, Kimball SM, Kolasinski J, Ramagopalan SV, Ebers GC. Review: the role of vitamin D in nervous system health and disease. Neuropathol Appl Neurobiol. 2013 Aug;39(5):458-84. doi: 10.1111/nan.12020. DeLuca GC, 2013

Eyles DW, Feron F, Cui X, Kesby JP, Harms LH, Ko P, McGrath JJ, Burne TH. Developmental vitamin D deficiency causes abnormal brain development. Psychoneuroendocrinology. 2009 Dec;34 Suppl 1:S247-57. doi: 10.1016/j.psyneuen.2009.04.015. Epub . Review. Eyles DW, 2009

Furthermore, the vitamin D theory of autism explains most of the epidemiological facts of ASD.

Cannell JJ. On the aetiology of autism. Acta Paediatr. 2010 Aug;99(8):1128-30. Cannell JJ, 2010

Cannell JJ. Autism and vitamin D. Med Hypotheses. 2008;70(4):750-9. Cannell JJ, 2008

70% of American toddlers do not take the American Pediatric Association's recommended vitamin D supplement of 400 IU/day. As milk consumption has fallen, so have toddler’s vitamin D levels.

Cannell JJ. Autism, will vitamin D treat core symptoms? Medical Hypotheses. 2013 Aug;81(2):195-8. Cannell JJ, 2013

Some autism researchers seem cognizant of the entire body of autism research. For example, a group of well-known European autism researchers, including Professor Christopher Gillberg of the Gillberg Neuropsychiatric Institute, have recently called for the need for “urgent research” into the vitamin D deficiency theory of ASD.

Kočovská E, Fernell E, Billstedt E, Minnis H, Gillberg C. Vitamin D and autism: clinical review. Res Dev Disabil. 2012 Sep-Oct;33(5):1541-50. doi: 10.1016/j.ridd.2012.02.015. Epub 2012 Apr 21.Kočovská E, 2012

However, these scientists appear to be in the minority. Until all autism researchers become cognizant of the wider body of scientific research, we will continue to wonder how to prevent - and perhaps even treat - this modern day plague.

John J Cannell, MD

Vitamin D Council

http://www.vitamindcouncil.org

On 2017 May 31, David Nunan commented:

Readers may not be aware of the notice of concern raised with this paper and another paper (Paterna S, 2008) by the same group published in Clinical Science in 2008, both of which were included in a 2012 systematic review published in BMJ Open Heart which was subsequently retracted. Whilst there is a link above to the notice of concern, here I've provided the contents of that notice. This paper has not been retracted.

Concern has been raised regarding a paper published in the Journal of Cardiac Failure: “Long-Term Effects of Dietary Sodium Intake on Cytokines and Neurohumoral Activation in Patients With Recently Compensated Heart Failure,” by Parrinello et al, J Card Fail 2009;15:864–73. The paper contains a dataset identical to that published by the same authors in Clinical Science 2008;114:221–30. The corresponding author, Dr di Pasquale of Palermo, Italy, has indicated that an error was made during a “cut and paste” process, and a table from the 2008 Clinical Science paper was mistakenly reproduced in the 2009 Journal of Cardiac Failure paper. Dr di Pasquale also coauthored an online manuscript in Heart, August 21, 2012, using a meta-analysis of 6 earlier papers, and that online report also includes the duplicated data. When questioned about the data, Dr di Pasquale reported that by unintentional error he had inserted the table from the earlier 2008 paper (Clinical Science) into the 2009 paper (Journal of Cardiac Failure). The Dean of the Medical School at the University of Palermo was notified and asked to investigate the matter. It was reported that Dr di Pasquale lost the raw data owing to a “computer crash” without having made backup files. The data are therefore not verifiable. Based on the information at hand, we have been unable to independently determine with certainty the cause of duplication of the dataset. Given the fact that there are duplicate data published, and there is no way to validate or verify the veracity of the data, readers should be cautioned in the application of the findings reported in these manuscripts to their clinical practice.

Gary S. Francis, MD Professor of Medicine, University of Minnesota Editor-in-Chief, Journal of Cardiac Failure http://dx.doi.org/10.1016/j.cardfail.2013.05.015

On 2017 Aug 20, Daniel Weiss commented:

This paper shows the insensitivity of two tiered testing for Lyme disease. Patients were “categorized as having Lyme disease, and met the CDC surveillance criteria for diagnosis”, i.e. positive serology or positive culture. Nonetheless, only “two-thirds of patients with acute neuroborreliosis or carditis … were seropositive by two-tier testing”. Therefore, one third were negative.

These authors also state that “IgM testing in Lyme disease has been problematic” and the CDC requirement that “IgM criteria should only be used to support the diagnosis of early LD in persons with illness of <1 month duration” “reduces the sensitivity of serologic testing” in certain patient groups.

This is one of many papers that argue against the reliance on serologic tests to rule out Lyme disease.

On 2014 Oct 15, Amanda Capes-Davis commented:

More recent work has shown that hTERT-EEC is misidentified and is actually MCF-7. So hTERT-EEC cells are from breast carcinoma, not immortalized endothelium.

It's important to test cell lines to confirm they correspond to the expected donor and are not cross-contaminated, using a consensus technique such as STR profiling. Journals are increasingly requiring testing as a prerequisite before publication and this will help to address the widespread use of misidentified cell lines in the scientific literature.

It's also a good idea to check before using a cell line to see if others have documented a problem previously. ICLAC maintains a list of known misidentified cell lines at http://iclac.org/databases/cross-contaminations/.

On 2014 Nov 19, Kaccie Li commented:

The authors of this study generalized the subjects from the United States to be white/Caucasian which is a serious oversight. A cursory look at US demographics would reveal that just over 75 percent of the population is white which is probably already questionable to generalize the entire group as white, but a closer look reveals even more concerning factors. Consider the populations in the studies classified under "white" in Table 2 of this article where the first two entries were studies done by Wang and colleagues (ref 13) and Porter and colleagues (ref 14). The first study was done at Baylor College of Medicine where a meager 43 percent of the student population is white. Suppose subject recruitment was done in the city Houston in general, the conclusions of Lim's study can be further put under scrutiny since only about 25 percent of Houston's population is white (non-hispanic). Similar things could be stated about individuals recruited in Porter's study (ref 14) at the University of Rochester where only about 76 percent of the student body is white. Lim and Fam does not mention the possibility of the presence of significant African and Asian Americans being an unknown factor that could have affected their results and conclusions.

On 2015 Dec 01, S A Ostroumov commented:

DOI:10.1134/S0012496609050159; In the presence of this aquatic, submerged, free-floating higher plant (rigid hornwort) in water system, it was occured that a decrease in concentrations of the four heavy metals (cadmium; copper; lead; zinc; Cu, Zn, Cd, and Pb) in the water medium accelerated. The aquatic macrophytes served as a factor to speed up the water purification (decontamination) process in the aquatic system. The method for measuring the heavy metals was stripping voltammetry. This paper is in the database of the United States Environmental Protection Agency (U.S.EPA), titled: Health & Environmental Research Online (HERO): http://hero.epa.gov/index.cfm?action=reference.details&reference_id=362778; FULL TEXT ONLINE FREE: https://www.researchgate.net/publication/40481671; KEYWORDS: the additional keywords for this paper in the database HERO: phytoremediation; polluted water; water pollution; water quality; Ceratophyllum demersum; Ceratophyllum; Ceratophyllaceae; Nymphaeales; dicotyledons; angiosperms; Spermatophyta; plants; eukaryotes; water composition and quality; Aquatic Biology and Ecology (MM300); Water Resources (PP200); Pollution and Degradation (PP600); Industrial Wastes and Effluents. The additional keywords: decontamination, aquatic, submerged, free-floating, higher plant, phytotechnology, ecotechnology, macrophytes, environmental toxicology, environmental chemistry, hornwort, rigid hornwort, coontail, coon's tail, stripping voltammetry; **

On 2014 Jan 15, Patricia Duffel commented:

Considerable changes to PubMed have taken place since this was written. I suggest taking a look at https://www.ncbi.nlm.nih.gov/books/NBK3827/

On 2015 Oct 15, Nanjiang Shu commented:

Link to the web-server has been changed to http://frag1d.bioshu.se

On 2014 Aug 01, Mark Yarchoan commented:

Overall, this study raises interest in a link between metabolic derangements and Alzheimer’s disease (AD). However, one concern I have is that in evaluating a possible association between low circulating leptin and incident dementia, the authors adjusted for current BMI, but not amount or direction of recent weight change. It is well known (and reiterated in this article) that, “Although midlife obesity is associated with an increased risk of AD, late-life weight loss is known to precede the onset of clinical AD.” Therefore, it is to be expected that the AD and normal groups might have similar overall weight and BMI, but a different direction and rate of BMI change (AD group rapidly losing weight, normal aging group keeping or gaining weight). Leptin levels are correlated with current body fat mass, but appear to be even more significantly affected by direction of weight change. For example, 14% intentional weight loss in human subjects results in a 64.5% reduction in leptin levels (Sumithran et al. NEJM 2014/ PMID: 22029981). Therefore, I am concerned that the observed differences in leptin levels in this study may simply be a consequence of the significant and early weight loss seen in AD.

On 2014 Mar 12, Diana Frame commented:

The full text link provided for this article does not work, but full text can be found here: http://www.annalsoftransplantation.com/download/index/idArt/880549 . Note that it's only "free full text" if you choose the personal copy option.

On 2014 Jul 02, Balázs Győrffy commented:

Our paper described the analysis tool as it was at the time of publication. For a more up-to-date description please check either the homepage (www.kmplot.com) or our latest publication (http://www.ncbi.nlm.nih.gov/pubmed/?term=24367507).

On 2015 Oct 07, Peter Good commented:

Shaw recently presented compelling evidence that acetaminophen (Tylenol) depletes glutathione in autism, asthma, and other disorders: “The characteristic loss of Purkinje cells in the brains of people with autism is consistent with depletion of brain glutathione due to excess acetaminophen usage, which leads to premature brain Purkinje cell death.”[1] Shaw observed that Cuba vaccinates all their children, especially against measles, yet their autism incidence is only 1/300th of ours in the U.S. What’s the difference, according to Shaw? Cuba prohibits over-the-counter acetaminophen, and only rarely allows acetaminophen prescribed for vaccinations, because acetaminophen is limited by the embargo. Deth noted that acetaminophen (like mercury) readily binds selenium-containing proteins that underlie the glutathione system [2]. By depleting glutathione, acetaminophen may effectively deplete glutamine because glutamine enters cells more easily than glutamate, thus often provides glutamate to synthesize glutathione [3].

As Shaw noted, Bauer and Kriebel reported recommendations that acetaminophen (paracetamol in the UK) be given before and after circumcision: “These guidelines include the suggestion of a first dose . . . two hours prior to the procedure, and doses every 4–6 hours for 24 hours following the procedure. Thus newborn males often receive 5–7 doses . . . during the developmentally vulnerable initial days of life.” They also cited evidence that may explain the increased number of children born autistic: “In the early 1980’s about 42% of women used paracetamol during the first trimester of pregnancy. The rate climbed to over 65% in the early 1990’s, where it has essentially remained through 2004.”[4]

For further evidence of glutathione depletion in autism, see: Chronic neurochemical asymmetry and dysconnection in autism. Implications of a personal trial of oral citrulline + taurine – published at <http:/www.autismstudies.net>

references 1. Shaw W. Evidence that increased acetaminophen use in genetically vulnerable children appears to be a major cause of the epidemics of autism, attention deficit with hyperactivity, and asthma. J Restorative Medicine 2013;2:1–16. 2. Deth R (PhD). Personal communication 2010. 3. Hong RW, Rounds JD, Helton SW, Robinson MK, Wilmore DW. Glutamine preserves liver glutathione after lethal hepatic injury. Ann Surg 1992;215:114–119. 4. Bauer AZ, Kriebel D. Prenatal and perinatal analgesic exposure and autism: an ecological link. Environ Health 2013;12:41.

On 2013 Nov 01, Darren L Dahly commented:

I am currently drafting a paper following from this work that uses mixture modelling to cluster study participants based on these socio-economic indicators. A poster of the preliminary work can be found here. http://f1000.com/posters/browse/summary/1089836 It offers a different perspective from this previous paper that focused on results from linear models.

On 2014 Mar 13, Jonathan Eisen commented:

I am the senior author on this paper and I have written a detailed blog post describing some of the history behind the project and other details. See "Story Behind the Nature Paper on 'A phylogeny driven genomic encyclopedia of bacteria & archaea'"

On 2014 Mar 15, Jonathan Eisen commented:

Carl Zimmer wrote an article in the New York Times about this paper. See Scientists Start a Genomic Catalog of Earth’s Abundant Microbes

On 2014 Feb 07, Saša Branković commented:

This theory is a (probably unintentional) plagiarism. Because, Manfred Velden (1974) had introduced the uncertainty (entropy) processing hypothesis of the orienting response and Saša Branković (2001) implemented the model into the theory of motivation, which has been called the theory of informational needs.

On 2016 Feb 18, Kristina Hanspers commented:

The interactome in figure 1b is available in the "Open Access Publication" collection at WikiPathways: http://www.wikipathways.org/index.php/Pathway:WP2916. This pathway can be downloaded for use in network analysis tools such as Cytoscape and PathVisio.

On 2014 Apr 10, Alexander Klabnik commented:

I recommend

On 2016 Aug 08, Stuart RAY commented:

The single line "Erratum in Correction [Hepatology. 2015]" above does not capture the complex recent history of this publication. That correction notes a 12-fold (person-years vs. person-months) calculation error that, once corrected, eliminates any statistical difference in HCC rates between those with HBsAg loss and those with HCC persistence.

Fortunately, an alert and astute reader (Chee-Kiat Tan, Singapore General Hospital) called attention to the important implications of this error in a Letter to the Editor [which, I hope, will be linked from this Pubmed record]. The authors provided a fairly terse reply.

In a notably rare Editorial response to Tan's letter, Michael Nathanson and Norah Terrault note that a key conclusion of the report is arguably strengthened by the correction: that HCC can occur in persons even after HBsAg loss, even in the absence of cirrhosis.

The importance of vigilance for HCC in persons with HBV infection (even in the absence of detectable HBsAg) is amplified by this correction; careful reading of the literature is also emphasized.

On 2013 Nov 24, John Sotos commented:

Medical educators I’ve known have often cited the case histories in the Journal‘s CPCs as model presentations of clinical information.

Unfortunately, case 2-2010 jeopardizes this reputation by saying the patient experienced “an episode of pain in his left arm … that radiated to his heart” (1).

Medical trainees should not emulate this statement, for three reasons:

First, it is not believable. The complex innervation of thoracic structures prevents localization of pain to any internal organ.

Second, it is ambiguous. Many patients believe pain near the left breast is “heart pain” (2), whereas physicians generally associate retrosternal discomfort with cardiac ischemia.

Third, even if this statement were a direct quote from the patient, it violates the precept to “question [the patient] until sufficient details are obtained to categorize the symptom in medical terms” (3).

No institution of medical education can rest on its laurels. I hope The Journal will re-dedicate itself to maintaining its pre-eminence in this vital field.

(1) Isselbacher EM, Kligerman SJ, Lam KM, Hurtado RM. Case records of the Massachusetts General Hospital. Case 2-2010. A 47-year-old man with abdominal and flank pain. N Engl J Med. 2010 Jan 21;362(3):254-62. Pubmed 20089976 doi: 10.1056/NEJMcpc0905548.

(2) Wood P. Diseases of the Heart and Circulation. 2nd ed. London: Eyre and Spottiswoode, 1956. Page 4.

(3) DeGowin RL. DeGowin & DeGowin’s Bedside Diagnostic Examination. 5th ed. New York: Macmillan, 1987. Page 24.

On 2016 Nov 06, David Juurlink commented:

Regarding the risk of addiction during chronic opioid therapy, readers of this review are directed to the correspondence associated with Vowles KE, 2015, in which the authors note: "Importantly, of the 26 studies reviewed by Noble et al., only 2 (7.7%) reported rates of opioid addiction and those authors imputed (page 8) an addiction rate of zero in the other 24 studies (92.3%). Although there is clear utility in their broader findings, we would urge caution in assuming absence of any particular phenomenon simply because it is not reported."

On 2014 Oct 06, Anders von Heijne commented:

Wonderful!. This is a must read for all diagnosticians. But don´t miss Stanley DE, Campos DG. The logic of medical diagnosis. Perspect Biol Med. 2013 Spring;56(2):300-15 that takes the argument one step further.

On 2014 Jan 11, I-Chen Tsai commented:

Wow. PubMed now opens for comments, called PubMed commons!!

On 2014 Jul 14, Sally Gore commented:

Required reading for our library fellows as they work through their rotation in research and scholarly communication services.

On 2014 Jan 07, Brett Snodgrass commented:

Dear Author,

Thank you for the excellent article.

Please provide your kind attention to the distinction between the Thebesian veins and the vessels of Wearn.

Please consider the following post and associated links to PubMed related to the heart's vasculature. https://twitter.com/BrettSnodgrass1/status/417049983028690944

Comments and suggestions are welcome.

Thank you kindly.

On 2017 Jul 07, Morten Oksvold commented:

This article should have been retracted after an investigation by The University of Maryland found this article to contain "compromised" data (a total of 26 articles in 11 journals were affected). The journal Cancer Research was informed in August 2016, according to Retraction Watch.

http://retractionwatch.com/2017/04/26/university-asked-numerous-retractions-eight-months-later-three-journals-done-nothing/

On 2016 Apr 22, Morten Oksvold commented:

Please note that this article has been retracted due to plagiarism.

On 2014 May 20, Ivan Oransky commented:

This study has been retracted: http://retractionwatch.com/2014/05/19/seventh-retraction-appears-for-author-who-tampered-with-investigation/

On 2014 Sep 07, Ivan Oransky commented:

The authors of this retracted study are returning a $275,000 (AU)grant because of "misleaing and incorrect" information: http://retractionwatch.com/2014/08/29/australian-university-to-repay-275k-grant-because-of-misleading-and-incorrect-information/

On 2014 Dec 11, Ibrahim Masoodi commented:

Ulcerative colitis has remitting and relapsing course and is affecting millions around the globe.The biomarkers can predict the severity in a non invasive manner .There is a growing need to identify more useful biomarkers in order to predict an impending relapse . We found serum CRP and fecal markers MPO , Lactoferrin very useful.These correlated with endoscopic severity and disease activity

On 2014 Jan 14, Sergei Jargin commented:

More details: Jargin SV. Some aspects of dental caries prevention and treatment in children: a view from Russia. Pesq Bras Odontoped Clin Integr, João Pessoa 2010; 10(2):297-300. http://revista.uepb.edu.br/index.php/pboci/article/viewFile/959/464

On 2014 Jan 13, Amanda Capes-Davis commented:

This list of cross-contaminated or misidentified cell lines is now curated by the International Cell Line Authentication Committee (ICLAC). You can download the latest version at http://iclac.org/databases/cross-contaminations/

On 2014 Nov 19, Amanda Capes-Davis commented:

Cell lines that are known to be misidentified are now also hosted in the NCBI BioSample database at http://www.ncbi.nlm.nih.gov/biosample/.

The list of known misidentified cell lines continues to be updated by ICLAC and has a dedicated webpage at http://iclac.org/databases/cross-contaminations/.

Many thanks to Tanya Barrett and NCBI staff for their work in making the data more widely accessible.

On 2016 May 10, Morten Oksvold commented:

Please pay attention to the following report by ORI (Office of Research Integrity) before reading this article:

https://ori.hhs.gov/content/case-summary-pastorino-john-g

On 2017 Jun 27, Andy Collings commented:

A subset of experimental results from this study were the focus of a replication attempt as part of the Reproducibility Project: Cancer Biology (https://osf.io/e81xl/wiki/home/). The experimental designs and protocols were reviewed and approved in a Registered Report (http://dx.doi.org/10.7554/eLife.12626) and the results of the experiments were published in a Replication Study (http://dx.doi.org/10.7554/eLife.26030).

On 2014 Jan 08, Tom Kindlon commented:

Early diagnosis of CFS/ME has been shown to lead to a better prognosis

It was interesting to see the various views expressed by GPs in this paper[1]. However I think a couple of useful points could have been added. There is much discussion in the paper about whether a label of CFS/ME is useful or not. The authors refer to NICE guidelines which "emphasise the importance of a definitive diagnosis"[2]. However, I think it would have been useful to add some direct evidence on this issue.

For example, research published by the Centres for Disease Control and Prevention (CDC) which found that an earlier diagnosis led to a better prognosis[3]. This prompted the CDC to launch a two-pronged awareness drive aimed at both health professionals and the general public - the tag line for the latter was, "Get informed. Get diagnosed. Get help."[4].

A UK study found that the longer the interval between a patient falling ill and getting a diagnosis, the greater the likelihood that they would become severely affected. [5]

The authors mention the issue of CFS/ME being managed in primary care. It is important for GPs to know that GPs encouraging patients to do a graded exercise programme is associated with a higher rate of adverse reactions. For example, a survey which asked patients about their experiences of treatments over the previous three years found that 45% reported being made worse by a graded exercise therapy (GET) programme overseen by their GP, compared to 31% who reported being made worse by a GET under a NHS specialist and 29% of those who did a GET in other circumstances[6]. The NICE guidelines do not recommend that a GP oversee such an approach[2].

References:

[1] Chew-Graham C, Dowrick C, Wearden A, Richardson V, Peters S. Making the diagnosis of Chronic Fatigue Syndrome/Myalgic Encephalitis in primary care: a qualitative study. BMC Fam Pract. 2010 Feb 23;11:16.

[2] NICE CG 53 Chronic fatigue syndrome/Myalgic encephalomyelitis (or encephalopathy) guideline.

[3] Nisenbaum R, Jones JF, Unger ER, Reyes M and Reeves WC. A population-based study of the clinical course of chronic fatigue syndrome. Health and Quality of Life Outcomes 2003;1:49-58.

[4] CDC Chronic Fatigue Syndrome Awareness Campaign. http://cdc.gov/cfs/awareness.htm [Last accessed: 31 March, 2010]

[5] Pheby D and Saffron L. Risk factors for severe ME/CFS. Biology and Medicine (2009); 1 (4):50-74. http://biolmedonline.com/Articles/vol1_4_50-74.pdf [Last accessed: 31 March, 2010]

[6] Action for M.E. and AYME Survey 2008 Results http://afme.wordpress.com/5-treatments-and-symptoms/ [Last accessed: 31 March, 2010]

On 2016 Jul 01, Anne Niknejad commented:

'It has been shown that apoptotic stimuli induce nuclear accumulation of GSK3β colocalising it with p53 [15]. This study reported that there was no nuclear accumulation of GSK3β after DNA damage (induced by camptothecin treatment) but rather an exclusive activation of the nuclear pool with no activation of cytosolic pools. The authors showed that p53 coimmunoprecipitates with GSK3β from nuclear fractions after camptothecin treatment.'

Actually the reference 15 is wrong, no 'p53' mention, no camptothecin treatment (but staurosporine treatment)

http://www.ncbi.nlm.nih.gov/pubmed/?term=11495916

The correct reference could be

http://www.ncbi.nlm.nih.gov/pubmed/?term=12048243

(not cited in References)

On 2013 Nov 24, John Sotos commented:

In his letter describing recently-introduced Congressional legislation to establish “healthcare innovation zones” (1), Dr. Kirch of the Association of American Medical Colleges (AAMC) listed his financial disclosures as “none.” I believe this is misleading.

Dr. Kirch did not disclose that the AAMC proposed such zones (2). As a federally registered lobbying organization that has spent $100,000-$400,000 annually on lobbying activities since 1999 (3), common sense dictates that one of the AAMC’s “products” is legislation.

Thus, Dr. Kirch should have disclosed his organization’s role in the product his letter described, just as he would have disclosed if his organization had invented a new drug or device expected to benefit the organization or its affiliates. At the very least, such disclosure would have helped the JAMA editors realize he was hyping something his organization helped create.

(1) Kirch DG. The Healthcare Innovation Zone: a platform for true reform. JAMA. 2010 Mar 3;303(9):874-875. Pubmed 20197534. doi: 10.1001/jama.2010.224.

(2) “Rep. Schwartz introduces legislation to establish AAMC-proposed health care innovation zones.” Press Release, Association of American Medical Colleges, July 10, 2009. Online at: http://www.aamc.org/newsroom/pressrel/2009/090710.htm — accessed April 4, 2010.

(3) Lobbying Disclosure Act Database: http://soprweb.senate.gov/index.cfm?event=choosefields — Searched on “registrant name” = “association of american medical colleges” on April 4, 2010.

On 2016 Apr 22, Morten Oksvold commented:

Please note that this article has been retracted.

On 2013 Oct 23, ANDREW SU commented:

!MOVED http://biogps.org

The URL in the original abstract has now been retired. This data set (together with other gene expression data sets) are now hosted at http://biogps.org.

On 2015 Mar 13, Martine Crasnier-Mednansky commented:

Escherichia coli cells growing on excess glucose (Fig. 3, Environment G) do not consume acetate after glucose depletion (the acetate switch occurs before glucose is fully depleted). In fact, cells utilize both glucose and acetate during entry into the stationary phase of growth (see Fig. 1A in Wolfe AJ, 2005). Failure to assimilate acetate before glucose depletion was reported for a specific mutant strain and resulted in a diauxic type of growth (Nyström T, 1993).

Acetate utilization by acetate-adapted cells is not diminished by glucose addition (Lowry OH, 1971). Furthermore glucose utilization by acetate-adapted cells is inhibited by acetate. It is therefore questionable whether acetate-adapted cells are `adapting´ to glucose when transferred to a medium containing a large excess of acetate (Fig. 3, Environment GA). In this context, the reversible phosphotransfer reaction between phosphoacetate kinase and the phosphotransferase system (PTS), originally proposed by Fox DK, 1986 but never established in vivo, should be physiologically relevant as to regulate the rate of sugar transport by the PTS and thus the cAMP level.

On 2015 Jul 25, Md. Shahidul Islam commented:

An updated version of this paper has been published in 2015. "Microscopic Anatomy of the Human Islet of Langerhans" Islets of Langerhans 2nd ed. 2015 Edition. Springer. PP 19-38. ISBN-13: 978-9400766853 ISBN-10: 9400766858 DOI 10.1007/978-94-007-6884-0_1-2

On 2015 Jul 25, Md. Shahidul Islam commented:

An updated version of this paper has been published in 2015. "The Comparative Anatomy of Islets" R. Scott Heller. in "Islets of Langerhans" ISBN-13: 978-9400766853 ISBN-10: 9400766858. Springer. 10.1007/978-94-007-6686-0_2

On 2015 Jul 26, Md. Shahidul Islam commented:

An updated version of this paper has been published in 2015 (with a different title). Islets of Langerhans, 2nd ed. Springer. Online ISBN: 978-94-007-6884-0.

"Regulation of Pancreatic Islet Formation". DOI 10.1007/978-94-007-6884-0_36-2

On 2015 Jul 26, Md. Shahidul Islam commented:

An updated version of this paper has been published in 2015. Islets of Langerhans, 2nd ed. Springer. Online ISBN: 978-94-007-6884-0.

"High-Fat Programming of β-Cell Dysfunction". DOI 10.1007/978-94-007-6884-0_3-6

On 2015 Jul 26, Md. Shahidul Islam commented:

An updated version of this paper has been published in 2015 (with a different title). Islets of Langerhans, 2nd ed. Springer. Online ISBN: 978-94-007-6884-0.

"(Dys)Regulation of Insulin Secretion by Macronutrients" DOI 10.1007/978-94-007-6884-0_4-3

On 2015 Jul 26, Md. Shahidul Islam commented:

An updated version of this paper has been published in 2015. Islets of Langerhans, 2nd ed. Springer. Online ISBN: 978-94-007-6884-0.

"Electrophysiology of Islet Cells" DOI 10.1007/978-94-007-6884-0_5-2

On 2015 Jul 26, Md. Shahidul Islam commented:

An updated version of this paper has been published in 2015. Islets of Langerhans, 2nd ed. Springer. Online ISBN: 978-94-007-6884-0.

"ATP-Sensitive Potassium Channels in Health and Disease" DOI 10.1007/978-94-007-6884-0_6-3

On 2015 Jul 26, Md. Shahidul Islam commented:

An updated version of this paper has been published in 2015. Islets of Langerhans, 2nd ed. Springer. Online ISBN: 978-94-007-6884-0.

"Role of Mitochondria in β-Cell Function and Dysfunction". DOI 10.1007/978-94-007-6884-0_7-2

On 2015 Jul 26, Md. Shahidul Islam commented:

An updated version of this paper has been published in 2015. Islets of Langerhans, 2nd ed. Springer. "Basement Membrane in Pancreatic Islet Function". Online ISBN: 978-94-007-6884-0. DOI 10.1007/978-94-007-6884-0_8-2

On 2015 May 10, Md. Shahidul Islam commented:

This review was published in 2010. In 2014, an updated version of this review has been published (DOI 10.1007/978-94-007-6686-0_9).

On 2015 Jul 26, Md. Shahidul Islam commented:

An updated version of this paper has been published in 2015. Islets of Langerhans, 2nd ed. Springer. Online ISBN: 978-94-007-6884-0.

"Electrical, Calcium, and Metabolic Oscillations in Pancreatic Islets". DOI 10.1007/978-94-007-6884-0_10-3

On 2015 Jul 26, Md. Shahidul Islam commented:

An updated version of this paper has been published in 2015. Islets of Langerhans, 2nd ed. Springer. Online ISBN: 978-94-007-6884-0.

"Proteomics and Islet Research" DOI 10.1007/978-94-007-6884-0_12-1

On 2015 Jul 26, Md. Shahidul Islam commented:

An updated version of this paper has been published in 2015. Islets of Langerhans, 2nd ed. Springer. Online ISBN: 978-94-007-6884-0.

"Mechanisms of Pancreatic β-Cell Apoptosis in Diabetes and Its Therapies". DOI 10.1007/978-94-007-6884-0_14-2

On 2015 Jul 26, Md. Shahidul Islam commented:

An updated version of this paper has been published in 2015. Islets of Langerhans, 2nd ed. Springer. Online ISBN: 978-94-007-6884-0.

"β-Cell Function in Obese-Hyperglycemic Mice (ob /ob Mice)". DOI 10.1007/978-94-007-6884-0_15-2

On 2015 Jul 26, Md. Shahidul Islam commented:

An updated version of this paper has been published in 2015. Islets of Langerhans, 2nd ed. Springer. Online ISBN: 978-94-007-6884-0.

"Immunology of β-Cell Destruction". DOI 10.1007/978-94-007-6884-0_18-2

On 2015 Jul 26, Md. Shahidul Islam commented:

An updated version of this paper has been published in 2015. Islets of Langerhans, 2nd ed. Springer. Online ISBN: 978-94-007-6884-0.

"Human Islet Autotransplantation" DOI 10.1007/978-94-007-6884-0_21-2

On 2015 Jul 26, Md. Shahidul Islam commented:

An updated version of this paper has been published in 2015. Islets of Langerhans, 2nd ed. Springer. Online ISBN: 978-94-007-6884-0.

"Successes and Disappointments with Clinical Islet Transplantation" DOI 10.1007/978-94-007-6884-0_23-1

On 2015 Feb 25, James Tsung commented:

Link to ultrasound videos: https://youtu.be/0T4LQDQ51Qo?list=PLHg2xyua_KjuxrcdSoJPaVHCJsdWrmDcI

On 2014 Sep 01, Matthew Katz commented:

This Phase II trial by RTOG demonstrated the ability to safely deliver ablative radiation doses to offer excellent local tumor control. It has transformed the prognosis for patients with medically inoperable non-small cell lung cancer. Whether stereotactic radiation can be an alternative to surgery is currently under study on protocol. But this trials clearly supports a role for stereotactic radiation in the body as well as its known role for treating brain tumors.

Improvements have been made in dose calculation and more data now support the findings of RTOG 0236. Further study is needed to fine tune best dose schedules, technique and immobilization. Whether there is any role in node positive patients remains to be determined.

On 2016 Aug 21, Morten Oksvold commented:

Please note that this article represents one of eleven publications which were found to contain false data, after an investigation led by ORI in 2015:

https://ori.hhs.gov/content/case-summary-dasmahapatra-girija

This article should therefor not be cited.

On 2015 Aug 27, Zhicheng Lin commented:

The evidence for unconscious activation of the prefrontal no-go network is unwarranted because the activation is unlikely to be unconscious in the study. This study underestimated the true level of awareness as recently revealed in a phenomenon called "priming of awareness" (Lin and Murray, 2014, 2015).

Refs: Lin, Z., Murray, S. O. (2014). Priming of awareness or how not to measure visual awareness. Journal of Vision, 14(1), 1–17. Lin, Z., Murray, S. O. (2015). Automaticity of unconscious response inhibition: Comment on Chiu and Aron (2014). Journal of Experimental Psychology: General, 144(1), 244–254.

Direct links to the refs: http://jov.arvojournals.org/article.aspx?articleid=2295565 http://psycnet.apa.org/journals/xge/144/1/244/

On 2017 Aug 14, Egon Willighagen commented:

The data from Table I and II is available as machine readable HTML+RDFa from http://egonw.github.io/cheminformatics.classics/classic1.html

On 2014 Apr 01, Christopher Southan commented:

An updated (2013) comparison of public bioactive chemistry databases is available as http://www.ncbi.nlm.nih.gov/pubmed/24533037

On 2017 Apr 01, Egon Willighagen commented:

Tony, the current code uses Java applets, but these are no longer usable on modern browsers due to discontinued support. Do you have an updated approach to include spectra from ChemSpider in webpages as you describe in the paper?

On 2017 Apr 12, Antony J. Williams commented:

None

On 2014 Jan 10, Helmi BEN SAAD commented:

The third author name is "BEN SAAD H" not "SAAD HB".

On 2016 Feb 07, Fang-Cheng Yeh commented:

The tool and source code are available at http://dsi-studio.labsolver.org/

On 2014 May 10, Ivan Oransky commented:

This paper has been retracted: http://retractionwatch.com/2014/05/08/retraction-appears-for-former-federal-contractor-who-faked-data/

On 2013 Dec 28, Tsuyoshi Miyakawa commented:

The finding of elevated D2High receptors in the CaMKIIalpha heterozygous knockout mice is quite interesting, regarding the possiblity that these mice may serve as an animal model of schizophrenia or bipolar disorder. We pointed out the possibility in our paper before(Yamasaki N, 2008), though it was not cited in this paper. I'd like to add that the same KO mice also show decreased cellular activity in dentate gyrus, while it is increased in CA1 in hippocampus (Hattori S, 2013), which is also consistent with the hippocampus dysfunction hypothesis of schizophrenia (Tamminga CA, 2010).

On 2016 Jun 08, Jafar Kolahi commented:

This article has been criticized at: Kolahi J, Bang H, Park JJ, Desbiens NA. CONSORT 2010 and Controversies Regarding Assessment of Blindness in RCTs. Dent Hypotheses 2010;1:99-105. doi:10.5436/j.dehy. 2010.1.00016.

Full text is available via: https://www.researchgate.net/profile/Jafar_Kolahi/publication/49583226_CONSORT_2010_and_Controversies_Regarding_Assessment_of_Blindness_in_RCTs/links/0f2cd8bca299367d1640cfd0.pdf

On 2015 Aug 06, Carrie Price commented:

Please correct the spelling of United States so that the article can be located through keyword searching.

On 2014 Sep 03, Matthew Katz commented:

This phase III trial is a classic example of how combined modality therapy (radiation combined with medical therapy) can provide effective cure for laryngeal cancer with an organ-preserving approach that can mean a major difference in quality of life. Surgery still may be needed, but for patients with a good response chemoradiation can be an effective nonsurgical treatment. More recent studies have suggested that doing the two treatments together (concurrent therapy) is superior though the toxicity may also be higher Forastiere AA, 2003

On 2014 May 09, Madhusudana Girija Sanal commented:

It is all about numbers! It is statistics which defines what cancer is! One reason is that all definitions are a matter convenience for humans to classify, work or learn. Definitions quite often cannot be ‘black and white’ and hence statistical approaches are wise. The author note that the sixth hall mark of six hallmarks defined by Hannan and Weinberg, that is “the ability to invade and metastasis” is the only ‘real’ hallmark of cancer. However it is known that everything moves around, invade and proliferate need not be a cancer- example is endometriosis. Giant-cell tumor of the bone is considered benign but can spread to other parts including the lungs. Moreover during embryonic development different cell lineages compete and invade each other. Winners proliferate secrete autocrine factors, attracts blood vessels, force defeated cells to apoptosis or even ‘eat’ them up. This is not cancer! So what can be the hallmark or defining features of cancer? What I am proposing is a preliminary outline which may be further modified by “Wiki” efforts to make it more accurate. The following conditions needs to be satisfied to define a cancer: 1) Non physiological rate of cell division. Non physiological rate is defined as a growth rate which is a statistical outlier spatially and temporally for a given type of cell and organism. 2) A change, genetic or epigenetic with reference to the healthy genome which is a statistical outlier spatially and temporally for a given cell type and organism. Healthy reference genome and epigenome may be defined as the genome of individuals which satisfy two conditions a) falling within the statistically defined normal range of anatomical and physiological parameters for a population b) demonstrated longevity above 99.9 percentile of the population of a given organism.

Cancer is a dynamic process-continuous evolution and selection. It is often,but not mandatory (at least theoretically) to be started by or seeded by a mutation and 'nurtured' or maintained by epigenetics. This is because epigenetic modification are faster as well as reversible. The effect of environment is mediated often (through cytokines, microRNA or even by physical factors) through epigenetic adaptations.Sooner or later more mutations and epigenetic changes accumulate during evolution and selection. This process is accelerated by chemotherapy (especially when using alkylating agents) radiation. Very specific and interesting mutations can evolve during targeted therapy (example-nilotinib).

On 2014 Feb 13, David Keller commented:

The April 2010 Resident's Clinic discussed a 38-year-old woman with a history of gastric bypass who presented with profound anemia due to severe copper deficiency. She was noted to have an abnormally high zinc level. Her copper deficiency was attributed mainly to malabsorption due to her bowel surgery, and it was also noted that high zinc levels may induce copper deficiency. The question then arises as to why her zinc level was so high. The only clue is that the patient "had a history of frequent upper respiratory infections". Unfortunately, she was not asked whether she had used any of the over-the-counter zinc lozenge products which are sold as alternative sore throat remedies (for example "Cold-Eze"). Clinicians should not neglect to inquire about such non-prescription remedies or supplements when taking a patient's medication history, as important information may be learned.

On 2014 Sep 06, Ryan Radecki commented:

Post-publication commentary: "The Most Dangerous Holiday!"

Here in the United States, it is Labor Day – a Federal holiday established in 1886 by U.S. President Grover Cleveland. We, apparently, have Canada to thank for this innovation.

But, what was actually news to me – Labor Day is actually the highest-volume holiday for pediatric trauma, outpacing all other holidays. I’d have thought 4th of July – with it’s various explosive devices – would be the most popular pediatric trauma holiday, but, between 1997 and 2006, Labor Day takes the lead, followed by Memorial Day, and 4th of July as a close third. Halloween, Easter, Thanksgiving, New Year’s and Christmas round out the list, in that order.

http://www.emlitofnote.com/2014/09/the-most-dangerous-holiday.html

On 2017 Aug 05, Fernando Castro-Chavez commented:

Dear Reader, Here is where I did the discovery for the first time that by using the rotating circular classic representation of the genetic code, a series of resonances were able to be found, such as that every 90 degrees we had the hydrophobic amino acids per each quadrant, and the same applies when studying the rest of the properties of the amino acids, there is resonance for the basic, and for the hydrophobic amino acids, as well as for the phosphorilatable ones. This lead me to discover the rules of variation, that equivalent amino acids, produced by equivalent codons allow for the equally functional diversity of proteins and enzymes making all the wonderful array of varieties within each group of compatible organisms, which are the ones capable to interbreed producing a fertile offspring. Sincerely, Fernando Castro-Chavez.

On 2017 Jan 20, Andy Collings commented:

A subset of experimental results from this study were the focus of a replication attempt as part of the Reproducibility Project: Cancer Biology (https://osf.io/e81xl/wiki/home/). The experimental designs and protocols were reviewed and approved in a Registered Report (http://dx.doi.org/10.7554/eLife.06959) and the results of the experiments were published in a Replication Study (http://dx.doi.org/10.7554/eLife.17584).

On 2016 Nov 18, Morten Oksvold commented:

An investigation committee at Wayne State University (WSU) recommends that 42 articles from Fazlul Sarkar to be retracted (report finished August 31, 2015). This article represents one of them.

This information was published by Retraction Watch (November 17, 2016) and you can find a link to the full report here:

http://retractionwatch.com/2016/11/17/details-of-investigative-report-into-sarkar-released-by-aclu/

This article should therefore no longer be cited.

On 2017 Apr 23, Md. Shahidul Islam commented:

In human beta cells TRPM5 is almost absent while its closest relative TRPM4 is abundant. Marabita F, and Islam MS. Pancreas. 2017 Jan;46(1):97-101. Expression of Transient Receptor Potential Channels in the Purified Human Pancreatic β-Cells. PMID: 27464700 DOI: 10.1097/MPA.0000000000000685

On 2016 Aug 24, Ben Goldacre commented:

This trial has the wrong trial registry ID associated with it on PubMed: both in the XML on PubMed, and in the originating journal article. The ID given is NCT00018255. We believe the correct ID, which we have found by hand searching, is NCT01068210.

This comment is being posted as part of the OpenTrials.net project^[1] , an open database threading together all publicly accessible documents and data on each trial, globally. In the course of creating the database, and matching documents and data sources about trials from different locations, we have identified various anomalies in datasets such as PubMed, and in published papers. Alongside documenting the prevalence of problems, we are also attempting to correct these errors and anomalies wherever possible, by feeding back to the originators. We have corrected this data in the OpenTrials.net database; we hope that this trial’s text and metadata can also be corrected at source, in PubMed and in the accompanying paper.

Many thanks,

Jessica Fleminger, Ben Goldacre*

[1] Goldacre, B., Gray, J., 2016. OpenTrials: towards a collaborative open database of all available information on all clinical trials. Trials 17. doi:10.1186/s13063-016-1290-8 PMID: 27056367

* Dr Ben Goldacre BA MA MSc MBBS MRCPsych<br> Senior Clinical Research Fellow<br> ben.goldacre@phc.ox.ac.uk<br> www.ebmDataLab.net<br> Centre for Evidence Based Medicine<br> Department of Primary Care Health Sciences<br> University of Oxford<br> Radcliffe Observatory Quarter<br> Woodstock Road<br> Oxford OX2 6GG

On 2014 Jun 01, Ivan Oransky commented:

This paper has been retracted: http://retractionwatch.com/2014/05/28/failure-to-cite-leads-to-ignoble-end-for-xenon-paper-and-a-correction/

On 2013 Dec 31, Tom Kindlon commented:

I had a response published: FINE trial for CFS. Missing data

BMJ. 2010 Jun 9;340:c2990. doi: 10.1136/bmj.c2990. FINE trial for CFS. Missing data. Kindlon T. http://www.ncbi.nlm.nih.gov/pubmed/20534661 Kindlon T, 2010

My original e-letter from which this was drawn can be read here: http://www.bmj.com/rapid-response/2011/11/02/missing-data

On 2015 Dec 24, Tom Kindlon commented:

Step test data were subsequently published

"There were no between group differences in any of the step test measures at 20 or 70 weeks"(1).

Reference:

Wearden AJ1, Emsley R. Mediators of the effects on fatigue of pragmatic rehabilitation for chronic fatigue syndrome. J Consult Clin Psychol. 2013 Oct;81(5):831-8. doi: 10.1037/a0033561.

On 2016 Nov 20, Morten Oksvold commented:

An investigation committee at Wayne State University (WSU) recommends that 42 articles from Fazlul Sarkar to be retracted (report finished August 31, 2015). This article represents one of them.

This information was published by Retraction Watch (November 17, 2016) and you can find a link to the full report here:

http://retractionwatch.com/2016/11/17/details-of-investigative-report-into-sarkar-released-by-aclu/

This article should therefore no longer be cited.

On 2016 Mar 18, ZHONGMING ZHAO commented:

My lab recently moved to the University of Texas Health Science Center at Houston. The database is now available at https://bioinfo.uth.edu/SZGR/.

On 2014 Jul 16, Egon Willighagen commented:

The Chemistry Development Kit has an Open Source (LGPL) implementation of these fingerprints: http://cdk.sf.net/.

On 2013 Oct 28, Jamie Horder commented:

A historical note: in January 2009, shortly before this study was due to be completed, it was terminated early on the instructions of the local Research Ethics Committee. The reason for this was that rimonabant had just been withdrawn from the European market due to concerns over the high prevalence of depression in users - ironically, the very phenomenon that motivated this study.