21 Matching Annotations
  1. Jan 2025
  2. Sep 2024
    1. Our estimated safe ESB is that around 50–60% of global land surface should be in largely intact, natural condition to halt species extinction, secure biosphere contributions to climate regulation, and stabilise regional water cycles.

      for - stats - earth system boundary - biodiversity - intact natural systems - 50 to 60% global land need to be intact

    1. The loss of the tail is inferred to have occurred around 25 million years ago when the hominoid lineage diverged from the ancient Old World monkeys (Fig. 1a), leaving only 3–5 caudal vertebrae to form the coccyx, or tailbone, in modern humans14.

      for - human evolution - loss of tail approximately 25 million years ago - identified genomic mechanism leading to loss of tail and human bipedalism - human ancestors - up to 60 Ma years ago

  3. Dec 2023
  4. Jun 2022
  5. May 2022
    1. Notre activité 2021 (produits)

      enlever les virgules des % sur le 2 ème diagramme stp ? Etablissements scolaires 11 % Autres partenaires 13 % Collectivités 9 % Syndic de rivières 8 % Agence de l'eau 30 % CR et ARS 11 % Fonds européens 1 % OFB 6 % Autres ressources 11 %

  6. Sep 2021
  7. Aug 2021
    1. Eminem on rhyming orange: "I put my orange, 4-inch door hinge in storage and ate porridge with George." #

    2. Eminem shows Anderson Cooper his form of commonplace book in a 60 Minutes interview.

      Instead of calling it "commonplacing", he uses the phrase "stacking ammo".

      Cooper analogizes the collection as the scrawlings of a crazy person. In some sense, this may be because there is no order or indexing system with what otherwise looks like a box of random pages.

      <small><cite class='h-cite via'> <span class='p-author h-card'>u/sorrybabyxo</span> in Eminem has his own version of commonplace system containing words that rhyme. : commonplacebook (<time class='dt-published'>08/10/2021 09:45:39</time>)</cite></small>

  8. Mar 2021
    1. Results for individual PALB2 variants were normalized relative to WT-PALB2 and the p.Tyr551ter (p.Y551X) truncating variant on a 1:5 scale with the fold change in GFP-positive cells for WT set at 5.0 and fold change GFP-positive cells for p.Y551X set at 1.0. The p.L24S (c.71T>C), p.L35P (c.104T>C), p.I944N (c.2831T>A), and p.L1070P (c.3209T>C) variants and all protein-truncating frame-shift and deletion variants tested were deficient in HDR activity, with normalized fold change <2.0 (approximately 40% activity) (Fig. 1a).

      AssayResult: 5.1

      AssayResultAssertion: Normal

      StandardErrorMean: 1

    2. A total of 84 PALB2 patient-derived missense variants reported in ClinVar, COSMIC, and the PALB2 LOVD database were selected

      HGVS: NM_024675.3:c.3296C>G p.(Thr1099Arg)

    1. Source Data

      AssayResult: 98.64

      AssayResultAssertion: Not reported

      ReplicateCount: 2

      StandardErrorMean: 5.5

      Comment: Exact values reported in “Source Data” file.

    2. Source Data

      AssayResult: 81.81

      AssayResultAssertion: Not reported

      ReplicateCount: 2

      StandardDeviation: 7.45

      StandardErrorMean: 5.27

      Comment: Exact values reported in “Source Data” file.

    3. We, therefore, analyzed the effect of 48 PALB2 VUS (Fig. 2a, blue) and one synthetic missense variant (p.A1025R) (Fig. 2a, purple)29 on PALB2 function in HR.

      HGVS: NM_024675.3:c.3539T>C p.(I1180T)

    1. Most Suspected Brugada Syndrome Variants Had (Partial) Loss of Function

      AssayResult: 59.7

      AssayResultAssertion: Indeterminate

      ReplicateCount: 41

      StandardErrorMean: 6.3

      Comment: This variant had mild loss of function (peak current >50% and <75% of wildtype), therefore it was considered inconclusive and neither abnormal nor normal in vitro function. (Personal communication: A. Glazer)

    2. we selected 73 previously unstudied variants: 63 suspected Brugada syndrome variants and 10 suspected benign variants

      HGVS: NM_198056.2:c.4382C>G p.(Thr1461Ser)

  9. Sep 2018
    1. The honorable member has taken occasion to find fault with the clause of the resolutions which provides that the lieutenant-governors shall be appointed by the Central Government, and sees in it great danger, especially to Lower Canada. Mr. SPEAKER, I should very much like to know what protection the population of the different provinces derive from the fact that the governors of the British North American Provinces are sent out to us from England. Under the existing system, our governor is responsible neither to the people nor to the House ; he depends entirely upon the English Government, to which he is responsible. Under the system proposed the lieutenant-governors will be appointed by the Central Government, to which they will necessarily be responsible for their actions. And in that Government we shall have more than one vote ; we shall be represented in it by our ministers, who will be there to cause every encroachment or arbitrary act which the lieutenant-governor may allow himself to commit, to be condemned.

      §§.58, 59, and 60 of the Constitution Act, 1867.

  10. Jan 2017
    1. IF you look at the stresses the shear stresses gets bigger to 45 degrees then gets smaller after 45 degrees. So why doesn't it follow the angle with seemingly the most stress. See Page: Why 30 degrees instead of 45 degrees Fracture Angle with sigma 1 Nature wants the minimum normal stress possible with the maximum shear stress possible and at 45 degrees we aren't in that sweet spot were the normal stress is as relatively small as possible and the shear spot is as relatively high as can been and this is at about 60 degrees this is why the faults will crack in the same orientation in nature.

  11. Nov 2016
    1. Hillary Clinton es la personificación de la palabra establishment. Desde que en 1979 se convirtiera en la primera dama de Arkansas, su nombre ha sido sinónimo de política. Nunca fue una primera dama al uso, ella quería tener una voz propia, se negaba a ser la sombra de su marido, algo que siempre ha molestado entre los círculos conservadores. Se la ha acusado de impertinente, de antipática y de poco carismática. Pero lo que más molesta de Clinton es el secretismo con el que ha gestionado su carrera.
  12. Oct 2015
    1. The articles obtained to review Trick Your Brain into Thrift by Paying with Cash by Crack Articles is a theory that can be held at both ends. The articles provided have several brushed details of numerous researches that have been done that links the psychological human being into using credits card. Vis versa there is not much details on how to make, trick, or psychologically change one’s mind into purchasing with cash. The psychological research lead to how one views cash and a credit card or how the individual’s emotions are effected by their economic stand point when making purchases. The types of sources influence by the credit card companies to encouraging the public into using their credit card are endless, but the top mechanism used today is earning money back while spending. A real soother to human ear, when one does not like to see cash disappear from their wallet. Acknowledging, the basis of the title that Cracked Article uses is clearly avoiding using cash. The title shouldn’t be Trick Your Brain into Thrift by Paying with Cash, but the Tricks Your Brain Uses to Have You Pay with Credit Cards or When Not to Shop to Be Thrift.