To further dissect the involvement of PTEN N-terminal region in its function, we performed a full Ala-scanning mutagenesis of the PTEN region from residue 2 to residue 43 (Ala residues were mutated to Val). The mutated r
[Paragraph-level] PMCID: PMC4398541 Section: RESULTS PassageIndex: 7
Evidence Type(s): Functional
Summary: Evidence Type: Functional | Mutation: A39V | Summary: The A39V mutation alters the nuclear accumulation of PTEN, indicating a change in its molecular function related to localization. Evidence Type: Functional | Mutation: D19A | Summary: The D19A mutation affects the cytoplasmic localization of PTEN, suggesting an alteration in its molecular function. Evidence Type: Functional | Mutation: G20A | Summary: The G20A mutation influences the cytoplasmic localization of PTEN, indicating a change in its molecular function. Evidence Type: Functional | Mutation: F21A | Summary: The F21A mutation impacts the cytoplasmic localization of PTEN, suggesting an alteration in its molecular function. Evidence Type: Functional | Mutation: K13A | Summary: The K13A mutation inhibits nuclear entry of PTEN, indicating a change in its molecular function related to localization. Evidence Type: Functional | Mutation: R14A | Summary: The R14A mutation inhibits nuclear entry of PTEN, suggesting an alteration in its molecular function. Evidence Type: Functional | Mutation: R15A | Summary: The R15A mutation inhibits nuclear entry of PTEN, indicating a change in its molecular function related to localization. Evidence Type: Functional | Mutation: E18A | Summary: The E18A mutation inhibits nuclear accumulation of PTEN, suggesting an alteration in its molecular function. Evidence Type: Functional | Mutation: D24A | Summary: The D24A mutation inhibits nuclear entry of PTEN, indicating a change in its molecular function. Evidence Type: Functional | Mutation: Y16A | Summary: The Y16A mutation inhibits nuclear entry of PTEN, suggesting an alteration in its molecular function. Evidence Type: Functional | Mutation: Y27A | Summary: The Y27A mutation inhibits nuclear entry of PTEN, indicating a change in its molecular function. Evidence Type: Functional | Mutation: I28A | Summary: The I28A mutation inhibits nuclear entry of PTEN, suggesting an alteration in its molecular function. Evidence Type: Functional | Mutation: N31A | Summary: The N31A mutation inhibits nuclear entry of PTEN, indicating a change in its molecular function. Evidence Type: Functional | Mutation: I32A | Summary: The I32A mutation inhibits nuclear entry of PTEN, suggesting an alteration in its molecular function. Evidence Type: Functional | Mutation: I33A | Summary: The I33A mutation inhibits nuclear entry of PTEN, indicating a change in its molecular function. Evidence Type: Functional | Mutation: P30A | Summary: The P30A mutation inhibits nuclear entry of PTEN, suggesting an alteration in its molecular function. Evidence Type: Functional | Mutation: N12A | Summary: The N12A mutation inhibits nuclear accumulation of PTEN, indicating a change in its molecular function. Evidence Type: Functional | Mutation: M35A | Summary: The M35A mutation inhibits nuclear accumulation of PTEN, suggesting an alteration in its molecular function.
Gene→Variant (gene-first): 5728:A39V 5728:Ala residues were mutated to Val 71:D19A 5728:D24A 5728:E18A 5728:F21A 5728:G20A 5728:I28A 5728:I32A 5728:I33A 5728:K13A 5728:L42A 5728:M35A 5728:N12A 5728:N31A 5728:P30A 100329167:R14A 5728:R15A 5728:Y16A 5728:Y27A
Genes: 5728 71 100329167
Variants: A39V Ala residues were mutated to Val D19A D24A E18A F21A G20A I28A I32A I33A K13A L42A M35A N12A N31A P30A R14A R15A Y16A Y27A