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  1. Apr 2023
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    Cell-extrinsic autophagy in mature adipocytes regulates anti-inflammatory response to intestinal tissue injury through lipid mobilization
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    1. EMBOpress 19 Apr 2023

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    biorxiv.org/content/10.1101/2021.10.25.465200v2
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    Deregulations of miR-1 and its target Multiplexin promote dilated cardiomyopathy associated with myotonic dystrophy type 1
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    1. EMBOpress 13 Apr 2023

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    biorxiv.org/content/10.1101/2022.09.06.506816v1
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    Efficient knock-in method enabling lineage tracing in zebrafish
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    1. EMBOpress 12 Apr 2023

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    biorxiv.org/content/10.1101/2022.07.15.500272v1
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    An innovative hematopoietic stem cell gene therapy approach benefits CLN1 disease in the mouse model
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    1. EMBOpress 12 Apr 2023

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    biorxiv.org/content/10.1101/2022.03.03.482460v1
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    Morphofunctional changes at the active zone during synaptic vesicle exocytosis
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    1. EMBOpress 12 Apr 2023

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    biorxiv.org/content/10.1101/2022.03.07.483217v2
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    The TUDOR domain of SMN is an H3K79me1 histone mark reader
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    1. EMBOpress 11 Apr 2023

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    biorxiv.org/content/10.1101/2022.10.06.511070v1
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    Preference of CAMSAP3 for microtubules with expanded lattice contributes to stabilization of the minus end
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    1. EMBOpress 11 Apr 2023

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    biorxiv.org/content/10.1101/2022.08.21.504720v2
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    Analysis of context-specific KRAS-effectors (sub)complexes in Caco-2 cells
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    1. EMBOpress 11 Apr 2023

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    biorxiv.org/content/10.1101/2022.08.15.503960v1
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    Single cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development
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    1. EMBOpress 11 Apr 2023

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    biorxiv.org/content/10.1101/2022.02.10.479999v2
  11. Mar 2023
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    Peroxisomes contribute to intracellular calcium dynamics
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2020.09.02.279174v1
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    An extended DNA-free intranuclear compartment organizes centrosomal microtubules in Plasmodium falciparum
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2021.03.12.435157v2
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    Non-canonical miRNA-RNA base-pairing impedes tumor suppressor activity of miR-16
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2021.11.30.470499v1
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    The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation, epithelial repair, and tumor growth
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2022.04.11.487842v1
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    Stepwise progression of beta-selection during T cell development as revealed by histone deacetylation inhibition
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2021.10.03.462949v4
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    Lack of peroxisomal catalase affects heat shock response in C. elegans
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2021.07.13.452156v1
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    Lineage Tracing Reveals Fate Bias and Transcriptional Memory in Human B cells
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2022.07.14.499766v2
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    Critical roles of ICOS in controlling Foxp3-expressing T follicular cell subsets during early-stage germinal center reactions
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2021.09.14.460384v2
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    The human MRS2 magnesium binding domain is a regulatory feedback switch for channel activity.
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2022.09.27.509701v1
  21. www.biorxiv.org www.biorxiv.org
    Hda1C limits divergent non-coding transcription and restricts transcription initiation frequency
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2021.04.06.438606v1
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    E-Cadherin mediated AMIS localisation
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2021.11.30.470571v5
  23. www.biorxiv.org www.biorxiv.org
    Reconstitution of centrosome positioning by the production of pushing forces in microtubules growing against the actin network.
    1
    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2022.01.21.476947v1
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    The Grainyhead/LSF transcription factor GRH-1 is rhythmically required for molting
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2022.03.01.482504v2
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    Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and C53-mediated autophagy
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2022.04.26.489478v1
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    An Arrayed Genome-Wide Perturbation Screen Identifies the Ribonucleoprotein hnRNP K As Rate-Limiting for Prion Propagation
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2022.03.03.482765v1
  27. www.biorxiv.org www.biorxiv.org
    Uncoupling from transcription protects polyadenylation site cleavage from inhibition by DNA damage
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2022.05.26.492040v2
  28. www.biorxiv.org www.biorxiv.org
    Mild impairment of mitochondrial function increases longevity and pathogen resistance through ATFS-1-driven activation of p38-regulated innate immunity
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2021.03.31.437812v1
  29. www.biorxiv.org www.biorxiv.org
    Rabaptin5 targets autophagy to damaged early endosomes and Salmonella containing vacuoles by interaction with FIP200 and ATG16L1
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2020.09.01.277764v2
  30. www.biorxiv.org www.biorxiv.org
    Protein-coding potential of RNAs measured by potentially translated island scores
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2021.04.14.439730v2
  31. www.biorxiv.org www.biorxiv.org
    Production of offspring from azoospermic mice with meiotic failure: Precise biparental meiosis within halved oocytes
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    biorxiv.org/content/10.1101/2021.09.03.458818v4
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    The Legionella-driven PtdIns(4)P gradient at LCV-ER membrane contact sites promotes Vap-, OSBP- and Sac1-dependent pathogen vacuole remodeling
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    biorxiv.org/content/10.1101/2022.06.17.496549v2
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    The spindle orienting machinery requires activation, not just localization
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2022.06.29.498167v1
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    Multinucleation resets human macrophages for specialized functions at the expense of mononuclear phagocyte identity
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2022.08.22.504763v1
  35. www.biorxiv.org www.biorxiv.org
    Blockade of pro-fibrotic response mediated by the miR-143/-145 cluster prevents targeted therapy-induced phenotypic plasticity and delays resistance in melanoma
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2021.07.02.450838v1
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    A spatial model of the plant circadian clock reveals design principles for coordinated timing under noisy environments
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    biorxiv.org/content/10.1101/2020.09.13.294785v2
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    iPSC-based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation
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    biorxiv.org/content/10.1101/2022.02.24.481741v1
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    The cryo-EM structure of the CENP-A nucleosome in complex with ggKNL2
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2022.06.24.497480v1
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    Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever
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    biorxiv.org/content/10.1101/2022.05.10.491306v1
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    The eukaryotic translation initiation factor eIF4E reprogrammes the splicing machinery anddrives alternative splicing
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2021.12.07.471666v4
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    Nanobody-mediated Complement Activation to Kill HIV-infected Cells
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    1. EMBOpress 10 Mar 2023

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    biorxiv.org/content/10.1101/2022.06.09.495439v1
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    Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases
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    1. EMBOpress 09 Mar 2023

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    biorxiv.org/content/10.1101/2022.02.18.481032v1
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    Segregation of pathways leading to pexophagy
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    biorxiv.org/content/10.1101/2022.11.08.515582v1
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    New algorithms for accurate and efficient de-novo genome assembly from long DNA sequencing reads
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    1. EMBOpress 09 Mar 2023

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    biorxiv.org/content/10.1101/2022.08.30.505891v1
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    Protein Complexes in Bacillus subtilis by AI-assisted structural proteomics
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    1. EMBOpress 09 Mar 2023

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    biorxiv.org/content/10.1101/2022.07.26.501605v3
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    Structure and mechanism of a novel cytomegaloviral DCAF mediating interferon antagonism
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    1. EMBOpress 07 Mar 2023

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    biorxiv.org/content/10.1101/2022.05.05.490734v2
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    The Proxitome of Arabidopsis Processing Bodies Reveals a Condensate-Membrane Interface Instructing Actin-Driven Directional Growth
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    1. EMBOpress 03 Mar 2023

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    biorxiv.org/content/10.1101/2022.06.03.494746v1
  48. Feb 2023
  49. www.biorxiv.org www.biorxiv.org
    Adenylyl cyclase 9 is auto-stimulated by its isoform-specific carboxyl terminal domain and equipped with paradigm-switching mechanisms.
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    1. EMBOpress 28 Feb 2023

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    biorxiv.org/content/10.1101/2022.06.05.494885v3
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    The mechanosensitive TRPV2 calcium channel controls melanoma invasiveness and metastatic potential.
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    biorxiv.org/content/10.1101/2021.10.22.465391v1
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    TORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes
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    1. EMBOpress 17 Feb 2023

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    biorxiv.org/content/10.1101/2022.08.08.503151v2
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    Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance
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    1. EMBOpress 17 Feb 2023

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    biorxiv.org/content/10.1101/2022.02.17.480899v1
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    Single cell clonal analysis identifies an AID-dependent pathway of plasma cell differentiation
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    MitoStores: Chaperone-controlled protein granules store mitochondrial precursors in the cytosol
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    The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting of the Ppg1-Far complex
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    Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis
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    The blood vasculature instructs lymphatics patterning in a SOX7-dependent manner
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    TSC2 regulates tumor susceptibility to TRAIL-mediated T cell killing by orchestrating mTOR signaling
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    Transient ribosome slowdown at the decoding step triggers mRNA degradation independent of Znf598 in zebrafish
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    Human RNA Nm-MTase FTSJ1: new tRNA targets and role in the regulation of brain-specific genes.
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    A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery
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    Epigenetic signals that direct cell type specific interferon beta response in mouse cells
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    CDK9 and PP2A regulate the link between RNA polymerase II transcription termination and RNA maturation.
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    Constricted migration contributes to persistent 3D genome structure changes associated with an invasive phenotype in melanoma cells
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    NuRD independent Mi-2 activity represses ectopic gene expression during neuronal maturation.
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    Evolution of genome fragility enables microbial division of labor
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    Convergent evolution and horizontal gene transfer in Arctic Ocean microalgae
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    A molecular mechanism by which amyloid-β induces transcriptional inactivation of CREB in Alzheimer's Disease
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  73. Jan 2023
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    A toolbox for systematic discovery of stable and transient protein interactors in baker's yeast
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    Structural and functional characterization of TraI from pKM101 reveals basis for DNA processing
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    Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2
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    Pan-Cancer landscape of protein activities identifies drivers of signalling dysregulation and patient survival
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    SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis.
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    Plasma membrane topography governs the three-dimensional dynamic localization of IgM B cell receptor clusters
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    Epigenetic centromere identity is precisely maintained through DNA replication but is uniquely specified among human cells
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    Identifying novel regulators of placental development using time series transcriptomic data and network analyses
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    An isoform-specific function of Cdc42 in regulating mammalian Exo70 during axon formation
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    CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium
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    Adaptation of bacterial proteome reveals a key role of the cell envelope in starvation survival
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    Condensin pinches a short negatively supercoiledDNA loop during each round of ATP usage
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    Comparative analysis of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing
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    A synergistic activation of RARb and RARg nuclear receptors restores cell-types specialization during stem cells differentiation by hijacking RARa-controlled program
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    NOTCH3 active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model
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    Porcine intestinal innate lymphoid cells and lymphocyte spatial context revealed through single-cell RNA sequencing
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    Stage-specific gene and transcript dynamics in human male germ cells
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    Endoplasmic Reticulum membranes are continuously required to maintain mitotic spindle size and forces
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    When Yeast Cells Change their Mind: Cell Cycle 'Start' is Reversible under Starvation
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    Structural and biochemical basis of FANCI-FANCD2 interdependent ubiquitination
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    Specific N-glycans regulate an extracellular adhesion complex during somatosensory dendrite patterning
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    The dengue virus NS1 protein conveys pro-inflammatory signals by docking onto human high-density lipoproteins
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    Drosophila pVALIUM10 TRiP RNAi lines cause undesired silencing of Gateway-based transgenes
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    The chromatin factor ROW cooperates with BEAF-32 in regulating long-range genes
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    HEAT SHOCK FACTOR BINDING PROTEIN limits meiotic crossovers by repressing HEI10 transcription
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    CellRegMap: A statistical framework for mapping context-specific regulatory variants using scRNA-seq
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    Heterotypic Assembly Mechanism Regulates CHIP E3 Ligase Activity
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    biorxiv.org/content/10.1101/2021.08.20.457118v1
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    Species richness determines C. difficile invasion outcome in synthetic human gut communities
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    biorxiv.org/content/10.1101/2021.03.23.436677v1
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    Basal Neural Stem Cells in the Subventricular Zone Drive Postnatal Neurogenesis with Apical Stem Cells Acting as Proliferation Gatekeepers
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    biorxiv.org/content/10.1101/2020.11.20.391102v4
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    Genetically-Modified Macrophages Accelerate Myelin Repair
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    biorxiv.org/content/10.1101/2020.10.28.358705v3
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    Mitotic checkpoint gene expression is tuned by coding sequences
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    Lifespan can be extended during a specific time window early in life
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    IL-21 lowers the B cell receptor affinity threshold for participation in a T cell dependent immune response.
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    Nanoengineered DNA origami with repurposed TOP1 inhibitors targeting myeloid cells for the mitigation of neuroinflammation
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    Structural mechanism underpinning Thermus oshimai Pif1-mediated G-quadruplex unfolding
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    ALS-linked KIF5A ΔExon27 mutant causes neuronal toxicity through gain of function
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    Nuclear Pore Complex Acetylation Regulates mRNA Export and Cell Cycle Commitment in Budding Yeast
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    Cellular toxicity of iHAP1 and DT-061 does not occur through PP2A-B56 targeting
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    biorxiv.org/content/10.1101/2021.07.08.451586v1
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    Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms
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    Cooperative Amyloid Fibre Binding and Disassembly by the Hsp70 disaggregase
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    Optogenetic actuator/biosensor circuits for large-scale interrogation of ERK dynamics identify sources of MAPK signaling robustness.
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    Longitudinal monitoring of disease burden and response using ctDNA from dried blood spots in xenograft models
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    Precise control of microtubule disassembly in living cells
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    Proteome-scale amino-acid resolution footprinting of protein-binding sites in the intrinsically disordered regions of the human proteome
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    Varicella-Zoster Virus ORF9 Is an Antagonist of the DNA Sensor cGAS
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    External light dark cycle shapes gut microbiota through intrinsically photosensitive retinal ganglion cells
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    THEM6-mediated lipid remodelling sustains stress resistance in cancer
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    Growth-dependent heterogeneity in the DNA damage response in Escherichia coli
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    Dynamic human liver proteome atlas reveals functional insights into disease pathways
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    Self-ubiquitination of a pathogen type-III effector traps and blocks the autophagy machinery to promote disease
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    A temporally controlled sequence of X-chromosomeinactivation and reactivation defines female mouse in vitro germ cells with meiotic potential
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    TRiC activates the unfolded protein response and protects starved stem cells by modulating energy and lipid metabolism during planarian regeneration
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    Reproducibility in systems biology modelling
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    biorxiv.org/content/10.1101/2020.08.07.239855v1
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    Structure of mammalian V-ATPase with the TLDc domain protein mEAK7 bound
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    Profiling subcellular localization of nuclear-encoded mitochondrial gene products in zebrafish
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  184. Oct 2022
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    https://biorxiv.org/cgi/content/10.1101/2022.03.06.483172
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    Replication-associated inversions are the dominant form of bacterial chromosome structural variation
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    Contribution of the Golgi apparatus in morphogenesis of a virus induced cytopathic vacuolar system
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    Regulation of Liprin-α phase separation by CASK is disrupted by a mutation in its CaM kinase domain
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    Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions
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    Synthetic evolution of herbicide resistance using a T7 RNAP-based random DNA base editor
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    Evaluation of CA repeat arrays as targets for MeCP2 function in the brain
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  192. Sep 2022
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    Meiotic DNA breaks activate a streamlined phospho-signaling response that largely avoids protein level changes
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    Human gene function publications that describe wrongly identified nucleotide sequence reagents are unacceptably frequent within the genetics literature
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  195. Aug 2022
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    Decreasing pdzd8-mediated mitochondrial-ER contacts in neurons improves fitness by increasing mitophagy
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    Islet Gene View - a tool to facilitate islet research
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    Resolution of the curse of dimensionality in single-cell RNA sequencing data analysis
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    CFTR modulator response measurements in subjects with cystic fibrosis using 2D differentiated nasal epithelia converted into spheroids
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    A minimal hepatocyte growth factor mimic acting as a powerful agonist of the MET receptor tyrosine kinase for regeneration of epithelial tissues and organs.
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    Drosophila insulator proteins exhibit in-vivo liquid-liquid phase separation properties
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    ScRNA-seq Expression of APOC2 and IFI27 Identifies Four Families of Alveolar Macrophage Superclusters in Cystic Fibrosis and Healthy BALF
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    ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1
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  204. Jul 2022
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    LncRNA RUS shapes the gene expression program towards neurogenesis
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  206. Jun 2022
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    Negative curvature-promoting lipids instruct nuclear ingression of low autophagic potential vacuoles
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    OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection
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    Genetic and compound screens uncover factors modulating cancer cell response to indisulam
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    biorxiv.org/content/10.1101/2021.12.20.473451v1
  210. www.biorxiv.org www.biorxiv.org
    Map7D2 and Map7D1 facilitate microtubule stabilization through distinct mechanisms to control cell motility and neurite outgrowth.
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    1. EMBOpress 01 Jun 2022

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      PeerReviewed EMBOPress Life Science Alliance cell biology
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    biorxiv.org/content/10.1101/2021.10.27.466197v3
  211. www.biorxiv.org www.biorxiv.org
    A RIF1 and KAP1-based, double-bookmarking system generates a toggle switch that stabilises the identities of the active and inactive X chromosomes during random X inactivation in mouse
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    1. EMBOpress 01 Jun 2022

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      PeerReviewed EMBOPress The EMBO Journal molecular biology
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    biorxiv.org/content/10.1101/2020.06.04.133512v2