17 Matching Annotations
  1. Feb 2025
  2. May 2024
    1. what formed the basis all the way from the 1950s to now so over a period 00:25:25 of over 70 years has really to be undone it has to be revised fundamentally root and Branch there can't be compromises about it

      for - quote - 70 years of evolutionary biology has to be undone

  3. Feb 2024
    1. De Bataafse Opstand, ook wel de opstand van de Bataven of opstand van de Batavieren genoemd, was een opstand (69 – 70) van de (vermoedelijk) West-Germaanse Bataven onder leiding van Gaius Julius Civilis in de militaire provincie Neder-Germanië (Germania Inferior)
  4. Jun 2023
  5. Aug 2022
  6. Mar 2021
    1. Results for individual PALB2 variants were normalized relative to WT-PALB2 and the p.Tyr551ter (p.Y551X) truncating variant on a 1:5 scale with the fold change in GFP-positive cells for WT set at 5.0 and fold change GFP-positive cells for p.Y551X set at 1.0. The p.L24S (c.71T>C), p.L35P (c.104T>C), p.I944N (c.2831T>A), and p.L1070P (c.3209T>C) variants and all protein-truncating frame-shift and deletion variants tested were deficient in HDR activity, with normalized fold change <2.0 (approximately 40% activity) (Fig. 1a).

      AssayResult: 4.9

      AssayResultAssertion: Normal

      StandardErrorMean: 0.29

    2. A total of 84 PALB2 patient-derived missense variants reported in ClinVar, COSMIC, and the PALB2 LOVD database were selected

      HGVS: NM_024675.3:c.3418T>G p.(Trp1140Gly)

    1. Source Data

      AssayResult: 102.22

      AssayResultAssertion: Not reported

      ReplicateCount: 2

      StandardErrorMean: 8.29

      Comment: Exact values reported in “Source Data” file.

    2. Source Data

      AssayResult: 97.16

      AssayResultAssertion: Not reported

      ReplicateCount: 2

      StandardDeviation: 1.32

      StandardErrorMean: 0.93

      Comment: Exact values reported in “Source Data” file.

    3. We, therefore, analyzed the effect of 48 PALB2 VUS (Fig. 2a, blue) and one synthetic missense variant (p.A1025R) (Fig. 2a, purple)29 on PALB2 function in HR.

      HGVS: NM_024675.3:c.92C>T p.(T31I)

    1. Most Suspected Brugada Syndrome Variants Had (Partial) Loss of Function

      AssayResult: 37.2

      AssayResultAssertion: Abnormal

      ReplicateCount: 26

      StandardErrorMean: 3.8

      Comment: This variant had partial loss of function of peak current (10-50% of wildtype), therefore it was considered abnormal (in vitro features consistent with Brugada Syndrome Type 1). (Personal communication: A. Glazer)

    2. we selected 73 previously unstudied variants: 63 suspected Brugada syndrome variants and 10 suspected benign variants

      HGVS: NM_198056.2:c.5164A>G p.(Asn1722Asp)

  7. Jun 2020
  8. Nov 2016
    1. "American Idiot" - Green Day

      Green Day's first number one album since 1994's multi-platinum Dookie--which is likely due to the fact that while the lyrics may have a deeper meaning, the hooks are still there, and they are played with the same intensity that made the group famous more than a decade ago. Spin said the title track was "Green Day's most epic song yet.

    2. Now everybody do the propaganda,And sing along to the age of paranoia.

      The work challenges listeners to dig deeper than the high-octane guitars and thundering drums that drive the record's jubilant pop sheen. This is a multi-layered, literate narrative that effectively wields anger, wit, and bombast to expose the ugliness that seeps below the surface of this country's patriotism, commercialism, and nationalism.

    3. We're not the ones who're meant to follow.

      "A lot of rock music lacks ambition. Rock has become stagnant. There are a lot of bands that aren't doing anything differently than what's currently going on in pop music--like issuing a single, putting out a record, making a video, and hopefully getting on a tour with a bigger band. I think the reason hip-hop has become so much bigger than rock lately is because those artists are much more ambitious, and they are making records that have a concept and characters. They sound like a script." ~Billy Joe Armstrong

    4. Television dreams of tomorrow.

      "All my songwriting is about creating a statement and taking action. On American Idiot, it's reflecting on what's going on in the world right now." ~Billy Joe Armstrong